J
Jesus F. Salazar-Gonzalez
Researcher at University of Alabama at Birmingham
Publications - 53
Citations - 11983
Jesus F. Salazar-Gonzalez is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Virus & Gene. The author has an hindex of 30, co-authored 49 publications receiving 11396 citations. Previous affiliations of Jesus F. Salazar-Gonzalez include Universidad Autónoma de San Luis Potosí & University of California, Los Angeles.
Papers
More filters
Journal ArticleDOI
Recurrent Signature Patterns in HIV-1 B Clade Envelope Glycoproteins Associated with either Early or Chronic Infections
Sandrasegaram Gnanakaran,Tanmoy Bhattacharya,Tanmoy Bhattacharya,Marcus Daniels,Brandon F. Keele,Brandon F. Keele,Peter T. Hraber,Alan Lapedes,Tongye Shen,Tongye Shen,Brian Gaschen,Mohan Krishnamoorthy,H Li,Julie M. Decker,Jesus F. Salazar-Gonzalez,Shuyi Wang,Chunlai Jiang,Chunlai Jiang,Feng Gao,Ronald Swanstrom,Jeffrey A. Anderson,Li-Hua Ping,Myron S. Cohen,Martin Markowitz,Paul A. Goepfert,Michael S. Saag,Joseph J. Eron,Charles B. Hicks,William A. Blattner,Georgia D. Tomaras,Mohammed Asmal,Norman L. Letvin,Peter B. Gilbert,Allan C. deCamp,Craig A. Magaret,William R. Schief,Yih-En Andrew Ban,Ming Zhang,Ming Zhang,Kelly A. Soderberg,Joseph Sodroski,Barton F. Haynes,George M. Shaw,Beatrice H. Hahn,Bette T. Korber,Bette T. Korber +45 more
TL;DR: The signature patterns identified implicate Env expression levels in selection at viral transmission or in early expansion, and suggest that immune evasion patterns that recur in many individuals during chronic infection when antibodies are present can be selected against when the infection is being established prior to the adaptive immune response.
Journal ArticleDOI
Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants (Journal of Virology (2009) 83, 8, (3556-3567))
Melissa-Rose Abrahams,Jeffrey A. Anderson,Elena E. Giorgi,Cathal Seoighe,Koleka Mlisana,Li-Hua Ping,Gayathri Athreya,Florette K. Treurnicht,Brandon F. Keele,Natasha T. Wood,Jesus F. Salazar-Gonzalez,Tanmoy Bhattacharya,Haitao Chu,Irving F. Hoffman,Shannon Galvin,Clement Mapanje,Peter N. Kazembe,Ruwayhida Thebus,Susan A. Fiscus,Winston Hide,Myron S. Cohen,S. S. Abdool Karim,Barton F. Haynes,George M. Shaw,Beatrice H. Hahn,Bette T. Korber,R. Swanstrom,Carolyn Williamson +27 more
Journal ArticleDOI
Comparison of Viral Env Proteins from Acute and Chronic Infections with Subtype C Human Immunodeficiency Virus Type 1 Identifies Differences in Glycosylation and CCR5 Utilization and Suggests a New Strategy for Immunogen Design
Li Hua Ping,Sarah B. Joseph,Jeffrey A. Anderson,Jeffrey A. Anderson,Melissa-Rose Abrahams,Jesus F. Salazar-Gonzalez,Laura P. Kincer,Florette K. Treurnicht,Leslie Arney,Suany Ojeda,Ming Zhang,Ming Zhang,Jessica Keys,E. Lake Potter,Haitao Chu,Penny L. Moore,Maria G. Salazar,Shilpa S. Iyer,Cassandra B. Jabara,Jennifer L. Kirchherr,Clement Mapanje,Nobubelo Ngandu,Cathal Seoighe,Irving F. Hoffman,Feng Gao,Yuyang Tang,Yuyang Tang,Celia C. LaBranche,Benhur Lee,Andrew Saville,Marion Vermeulen,Susan A. Fiscus,Lynn Morris,Salim S. Abdool Karim,Barton F. Haynes,George M. Shaw,Bette T. Korber,Bette T. Korber,Beatrice H. Hahn,Myron S. Cohen,David C. Montefiori,Carolyn Williamson,Ronald Swanstrom +42 more
TL;DR: It is suggested that the occasional absence of glycosylation sites encoded in the conserved regions of env, further reduced in transmitted viruses, could expose specific surface structures on the protein as antibody targets.
Journal Article
Reduced ecto-5'-nucleotidase activity and enhanced OKT10 and HLA-DR expression on CD8 (T suppressor/cytotoxic) lymphocytes in the acquired immune deficiency syndrome: evidence of CD8 cell immaturity.
Jesus F. Salazar-Gonzalez,Dewey J. Moody,Janis V. Giorgi,Otoniel Martinez-Maza,Ronald T. Mitsuyasu,John L. Fahey +5 more
TL;DR: The data presented here support the hypothesis they are immature, and reduced T cell ecto-5'-NT activity and enhanced expression of OKT10 and HLA-DR antigens on circulating CD8 cells, in conjunction with lack of transferrin receptor-(OKT9) and IL 2 receptor-(Tac) bearing lymphocytes, sustain this latter hypothesis.
Journal ArticleDOI
Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection.
Guido Ferrari,Bette T. Korber,N Goonetilleke,Michael K. P. Liu,Emma L. Turnbull,Jesus F. Salazar-Gonzalez,Natalie Hawkins,Steve Self,Sydeaka Watson,Sydeaka Watson,Michael R. Betts,Kara McGhee,Pierre Pellegrino,Ian Williams,Georgia D. Tomaras,Barton F. Haynes,Clive M. Gray,Persephone Borrow,Mario Roederer,Andrew J. McMichael,Kent J. Weinhold +20 more
TL;DR: Interestingly, only the magnitude of the total and not of the poly-functional T-cell responses was significantly associated with the selection of escape mutants, but the high contribution of MIP-1β-producing CD8+ T-cells to the total response suggests that mechanisms not limited to cytotoxicity could be exerting immune pressure during acute infection.