J
Jiangbai Luosang
Publications - 3
Citations - 2182
Jiangbai Luosang is an academic researcher. The author has contributed to research in topics: Population & Denisovan. The author has an hindex of 3, co-authored 3 publications receiving 1848 citations.
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Journal ArticleDOI
Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude
Xin Yi,Yu Liang,Emilia Huerta-Sanchez,Xin Jin,Zha Xi Ping Cuo,John E. Pool,John E. Pool,Xun Xu,Hui Jiang,Nicolas Vinckenbosch,Thorfinn Sand Korneliussen,Hancheng Zheng,Tao Liu,Weiming He,Kui Li,Ruibang Luo,Xifang Nie,Honglong Wu,Meiru Zhao,Hongzhi Cao,Jing Zou,Ying Shan,Shuzheng Li,Qi Yang,Asan,Peixiang Ni,Geng Tian,Junming Xu,Xiao Liu,Tao Jiang,Renhua Wu,Guangyu Zhou,Meifang Tang,Junjie Qin,Tong Wang,Shuijian Feng,Guohong Li,Huasang,Jiangbai Luosang,Wei Wang,Fang Chen,Yading Wang,Xiaoguang Zheng,Zhuo Li,Zhuoma Bianba,Ge Yang,Xiznping Wang,Shuhui Tang,Guoyi Gao,Yong Chen,Zhen Luo,Lamu Gusang,Zheng Cao,Qinghui Zhang,Wei-Han OuYang,Xiaoli Ren,Huiqing Liang,Huisong Zheng,Yebo Huang,Jingxiang Li,Lars Bolund,Karsten Kristiansen,Yingrui Li,Yong Zhang,Xiuqing Zhang,Ruiqiang Li,Songgang Li,Huanming Yang,Rasmus Nielsen,Rasmus Nielsen,Jun Wang,Jing Wang +71 more
TL;DR: A population genomic survey has revealed a functionally important locus in genetic adaptation to high altitude, and the strongest signal of natural selection came from endothelial Per-Arnt-Sim domain protein 1 (EPAS1), a transcription factor involved in response to hypoxia.
Journal ArticleDOI
Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA
Emilia Huerta-Sanchez,Xin Jin,Asan,Zhuoma Bianba,Benjamin M. Peter,Nicolas Vinckenbosch,Yu Liang,Xin Yi,Mingze He,Mehmet Somel,Peixiang Ni,Bo Wang,Xiaohua Ou,Huasang,Jiangbai Luosang,Zha Xi Ping Cuo,Kui Li,Guoyi Gao,Ye Yin,Wei Wang,Xiuqing Zhang,Xun Xu,Huanming Yang,Yingrui Li,Jian Wang,Jun Wang,Rasmus Nielsen +26 more
TL;DR: Re-sequencing the region around EPAS1 in 40 Tibetan and 40 Han individuals finds that this gene has a highly unusual haplotype structure that can only be convincingly explained by introgression of DNA from Denisovan or Denisovan-related individuals into humans.
Journal ArticleDOI
Archaeology Augments Tibet's Genetic History--Response
Xin Yi,Yu Liang,Emilia Huerta-Sanchez,Xin Jin,Zha Xi Ping Cuo,John E. Pool,John E. Pool,Xun Xu,Hui Jiang,Nicolas Vinckenbosch,Thorfinn Sand Korneliussen,Hancheng Zheng,Tao Liu,Weiming He,Kui Li,Ruibang Luo,Xifang Nie,Honglong Wu,Meiru Zhao,Hongzhi Cao,Jing Zou,Ying Shan,Shuzheng Li,Qi Yang,Asan,Peixiang Ni,Geng Tian,Junming Xu,Xiao Liu,Tao Jiang,Renhua Wu,Guangyu Zhou,Meifang Tang,Junjie Qin,Tong Wang,Shuijian Feng,Guohong Li,Huasang,Jiangbai Luosang,Wei Wang,Fang Chen,Yading Wang,Xiaoguang Zheng,Zhuo Li,Zhuoma Bianba,Ge Yang,Xinping Wang,Shuhui Tang,Guoyi Gao,Yong Chen,Zhen Luo,Lamu Gusang,Zheng Cao,Qinghui Zhang,Wei-Han OuYang,Xiaoli Ren,Huiqing Liang,Huisong Zheng,Yebo Huang,Jingxiang Li,Lars Bolund,Karsten Kristiansen,Yingrui Li,Yong Zhang,Xiuqing Zhang,Ruiqiang Li,Songgang Li,Huanming Yang,Rasmus Nielsen,Rasmus Nielsen,Jun Wang,Jing Wang +71 more
TL;DR: The understanding that the majority of the current population of the Tibetan plateau may trace their genetic ancestry back to quite recent immigrants into Tibet, even though humans have lived in Tibet for a much longer time—possibly with some continuity of culture—is important for understanding the difference between inferencesbased on archaeology and inferences based on genetics.