Jin-Wen Song

TL;DR: O surto do novo coronavírus (COVID-19) em Wuhan, China, iniciado em dezembro de 2019, evoluiu para se tornar uma pandemia global A.

TL;DR: Two monoclonal antibodies isolated from a patient with COVID-19 are shown to interfere with SARS-CoV-2–receptor binding, and one displays potent action against this virus in vitro and in a rhesus macaque model.

TL;DR: The single-cell transcriptional landscape of moderate, severe and convalescent cases of patients with COVID-19 describes the dynamic nature of immune responses during disease progression, and shows a deranged interferon response, profound immune exhaustion with skewed T cell receptor repertoire and broad T cell expansion.

TL;DR: It is suggested that GM3-enriched exosomes may partake in pathological processes related to COVID-19 pathogenesis, and the largest repository on the plasma lipidome and metabolome distinct to CO VID-19 is presented.

TL;DR: A higher degree of lymphopenia in various immune cell subsets as well as cytotoxicity and T cell inhibitory marker expression in severe cases compared with mild, indicate that immune-based targets for therapeutic interventions constitute a promising treatment for severe COVID-19 patients.