IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
Jochen Schmitz,Alexander Owyang,Elizabeth R. Oldham,Yaoli Song,Erin Murphy,Terril K. McClanahan,Gerard Zurawski,Mehrdad M. Moshrefi,Jinzhong Qin,Xiaoxia Li,Daniel M. Gorman,J. Fernando Bazan,Robert A. Kastelein +12 more
TLDR
A member of theIL-1 family, IL-33, which mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T( H)2 cells is reported.About:
This article is published in Immunity.The article was published on 2005-11-01 and is currently open access. It has received 3306 citations till now. The article focuses on the topics: Interleukin 10 & Interleukin-21 receptor.read more
Citations
More filters
Journal ArticleDOI
Immunological and Inflammatory Functions of the Interleukin-1 Family
TL;DR: The IL-1 family includes members that suppress inflammation, both specifically within the IL-2 family but also nonspecifically for TLR ligands and the innate immune response.
Journal ArticleDOI
The Inflammasomes: Guardians of the Body
TL;DR: The role of NLRs, and in particular the inflammasomes, in the recognition of microbial and danger components and the role they play in health and disease are discussed.
Journal ArticleDOI
A large-scale, consortium-based genomewide association study of asthma.
Miriam F. Moffatt,Ivo Gut,Florence Demenais,David P. Strachan,Emmanuelle Bouzigon,Simon Heath,Erika von Mutius,Martin Farrall,Mark Lathrop,William O.C.M. Cookson +9 more
TL;DR: A few common alleles are associated with disease risk at all ages and suggest a role for communication of epithelial damage to the adaptive immune system and activation of airway inflammation in asthma.
Journal ArticleDOI
Innate production of T H 2 cytokines by adipose tissue-associated c-Kit + Sca-1 + lymphoid cells
Kazuyo Moro,Taketo Yamada,Masanobu Tanabe,Tsutomu Takeuchi,Tomokatsu Ikawa,Hiroshi Kawamoto,Jun Ichi Furusawa,Masashi Ohtani,Hideki Fujii,Shigeo Koyasu +9 more
TL;DR: In this article, a new type of innate lymphocyte present in a novel lymphoid structure associated with adipose tissues in the peritoneal cavity was reported. But these cells do not express lineage (Lin) markers but do express c-Kit, Sca-1 (also known as Ly6a), IL7R and IL33R.
Journal ArticleDOI
CD4 T cells: fates, functions, and faults
Jinfang Zhu,William E. Paul +1 more
TL;DR: Much of what is known about the 4 CD4 T-cell subsets is summarized, including the history of their discovery, their unique cytokine products and related functions, their distinctive expression of cell surface receptors and their characteristic transcription factors, the regulation of their fate determination, and the consequences of their abnormal activation.
References
More filters
Journal ArticleDOI
The UCSC Genome Browser Database
Donna Karolchik,Robert Baertsch,Mark Diekhans,Terrence S. Furey,Angie S. Hinrichs,Yontao Lu,Krishna M. Roskin,Michael L. Schwartz,Charles W. Sugnet,Daryl J. Thomas,R. J. Weber,David Haussler,W. J. Kent +12 more
TL;DR: The University of California Santa Cruz (UCSC) Genome Browser Database is an up to date source for genome sequence data integrated with a large collection of related annotations that is optimized to support fast interactive performance with the web-based UCSC Genome browser.
Journal ArticleDOI
Enhanced genome annotation using structural profiles in the program 3D-PSSM.
TL;DR: Three-dimensional position-specific scoring matrix, 3D-PSSM, combines the power of multiple sequence profiles with knowledge of protein structure to provide enhanced recognition and thus functional assignment of newly sequenced genomes.
Journal ArticleDOI
IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo.
Madeline M. Fort,Jeanne Cheung,David C. Yen,Joana Li,Sandra Zurawski,Sylvia Lo,Satish Menon,Teresa Clifford,Brisdell Hunte,Robin Lesley,Tony Muchamuel,Stephen D. Hurst,Gerard Zurawski,Michael W. Leach,Daniel M. Gorman,Donna Rennick +15 more
TL;DR: The results suggest that IL-25, derived from Th2 T cells, is capable of amplifying allergic type inflammatory responses by its actions on other cell types.
Journal ArticleDOI
1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells.
Andre Boonstra,Franck J. Barrat,Chad Crain,Victoria L. Heath,Huub F. J. Savelkoul,Huub F. J. Savelkoul,Anne O'Garra +6 more
TL;DR: The findings suggest that vitD3 acts directly on Th cells and can, in the absence of APC, enhance the development of a Th2 phenotype and augment the expression of the transcription factors c-maf and GATA-3.
Journal ArticleDOI
The Interleukin-1 Receptor/Toll-like Receptor Superfamily: Signal Transduction During Inflammation and Host Defense
Aisling Dunne,Luke A. J. O'Neill +1 more
TL;DR: The interleukin-1 receptor/Toll-like receptor (IL-1R/TLR) superfamily plays a central role in inflammation and the host response to bacterial infection, and is evolutionarily conserved and a critical determinant of innate immune and inflammatory responses.