J
Jonathan L. Haines
Researcher at Case Western Reserve University
Publications - 463
Citations - 44478
Jonathan L. Haines is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 100, co-authored 463 publications receiving 40225 citations. Previous affiliations of Jonathan L. Haines include John P. Hussman Institute for Human Genomics & Bascom Palmer Eye Institute.
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Journal ArticleDOI
CALHM1 Polymorphism is not Associated with Late‐onset Alzheimer Disease
TL;DR: Data suggests that the P86L polymorphism in the calcium homeostasis modulator 1 (CALHM1) gene interferes with CALHM1 functionality, increases Aβ levels, and is associated with late‐onset Alzheimer's disease (LOAD).
Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals
Mahdi Ghani,Christiane Reitz,Rong Cheng,Badri N. Vardarajan,Gyungah Jun,Christine Sato,Adam C. Naj,Ruchita Rajbhandary,Li-San Wang,Otto Valladares,Chiao-Feng Lin,Eric B. Larson,Neill R. Graff-Radford,Denis A. Evans,Philip L. De Jager,Paul K. Crane,Joseph D. Buxbaum,Jill R. Murrell,Towfique Raj,Nilufer Ertekin-Taner,Mark W. Logue,Clinton T. Baldwin,Robert C. Green,Lisa L. Barnes,Laura B. Cantwell,M. Daniele Fallin,Rodney C.P. Go,Patrick Griffith,Thomas O. Obisesan,Jennifer J. Manly,Kathryn L. Lunetta,M. Ilyas Kamboh,Oscar L. Lopez,David A. Bennett,Hugh C. Hendrie,Kathleen S. Hall,Alison Goate,Goldie S. Byrd,Walter A. Kukull,Tatiana Foroud,Jonathan L. Haines,Lindsay A. Farrer,Margaret A. Pericak-Vance,Joseph H. Lee,Gerard D. Schellenberg,Peter St George-Hyslop,Richard Mayeux,Ekaterina Rogaeva +47 more
TL;DR: In this article, a case-control study of a large African American data set previously genotyped on different genome-wide SNP arrays was conducted from December 2013 to January 2015.
Journal ArticleDOI
Familial genetic predisposition, epilepsy localization and antecedent febrile seizures.
TL;DR: Although family history of epilepsy was more likely with generalized epilepsy, a familial tendency was considerable in partial epilepsy, and susceptibility for febrile seizures with subsequent epilepsy may be genetically distinct from susceptibility for afebrile seizure alone.
Journal ArticleDOI
A genetic linkage map of human chromosome 9q
Laurie J. Ozelius,David J. Kwiatkowski,Deborah E. Schuback,Xandra O. Breakefield,Nancy S. Wexler,James F. Gusella,Jonathan L. Haines +6 more
TL;DR: A comparison of the genetic map to the existing physical data suggests that there is increased recombination in the 9q34 region with a recombination event occurring every 125-400 kb.
Journal ArticleDOI
Refined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus (ALS2) on chromosome 2q33
Betsy A. Hosler,Peter C. Sapp,Ralph Berger,Gilmore O'Neill,Khemissa Bejaoui,Mongi Ben Hamida,Fayçal Hentati,Wendy Chin,Diane McKenna-Yasek,Jonathan L. Haines,David Patterson,H. Robert Horvitz,Robert H. Brown,C. B. Day +13 more
TL;DR: Five identified genes and 34 expressed sequence tags map within the region defined by crossover analysis and merit further consideration as candidate genes for this disease.