J
Jonathan L. Haines
Researcher at Case Western Reserve University
Publications - 463
Citations - 44478
Jonathan L. Haines is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 100, co-authored 463 publications receiving 40225 citations. Previous affiliations of Jonathan L. Haines include John P. Hussman Institute for Human Genomics & Bascom Palmer Eye Institute.
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Journal ArticleDOI
Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations
Farid Rajabli,Briseida E. Feliciano,Katrina Celis,Kara L. Hamilton-Nelson,Patrice L. Whitehead,Larry D. Adams,Parker Bussies,Clara P. Manrique,Alejandra Rodriguez,Vanessa C. Rodriguez,Takiyah D. Starks,Grace Byfield,Carolina B. Sierra Lopez,Jacob L. McCauley,Heriberto Acosta,Angel Chinea,Brian W. Kunkle,Christiane Reitz,Lindsay A. Farrer,Gerard D. Schellenberg,Badri N. Vardarajan,Jeffery M. Vance,Jeffery M. Vance,Michael L. Cuccaro,Michael L. Cuccaro,Eden R. Martin,Eden R. Martin,Jonathan L. Haines,Goldie S. Byrd,Gary W. Beecham,Gary W. Beecham,Margaret A. Pericak-Vance,Margaret A. Pericak-Vance +32 more
TL;DR: Factors contributing to the lower risk effect in the ApoE gene ε4 allele are likely due to ancestry-specific genetic factors near ApOE rather than non-genetic ethnic, cultural, and environmental factors.
Journal ArticleDOI
Identification of Genomic Predictors of Atrioventricular Conduction: Using Electronic Medical Records as a Tool for Genome Science
Joshua C. Denny,Marylyn D. Ritchie,Dana C. Crawford,Jonathan S. Schildcrout,Andrea H. Ramirez,Jill M. Pulley,Melissa A. Basford,Daniel R. Masys,Jonathan L. Haines,Dan M. Roden +9 more
TL;DR: In this article, the authors performed a genome-wide association study on 2334 European American patients with normal ECGs without evidence of prior heart disease from the Vanderbilt DNA databank, BioVU, which accrues subjects from routine patient care.
Journal ArticleDOI
A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death
Monica K Wetzel-Smith,Julie Hunkapiller,Tushar Bhangale,Karpagam Srinivasan,Janice A. Maloney,Jasvinder K. Atwal,Susan M Sa,Murat Yaylaoglu,Oded Foreman,Ward Ortmann,Nisha Rathore,David V. Hansen,Marc Tessier-Lavigne,Richard Mayeux,Margaret A. Pericak-Vance,Jonathan L. Haines,Lindsay A. Farrer,Gerard D. Schellenberg,Alison Goate,Timothy W. Behrens,Carlos Cruchaga,Ryan J. Watts,Robert R. Graham +22 more
TL;DR: It is proposed that one possible mechanism in which T835M UNC5C contributes to the risk of Alzheimer's disease is by increasing susceptibility to neuronal cell death, particularly in vulnerable regions of the Alzheimer's Disease brain.
Journal ArticleDOI
A meta-analysis of whole genome linkage screens in multiple sclerosis
Jonathan L. Haines,Graeme J. Stewart,Alastair Compston,George C. Ebers,Leena Peltonen,Sandra D'Alfonso,Maria Giovanna Marrosu,Jan Hillert,Mefkure Eraksoy +8 more
TL;DR: This work combined the raw genotyping data from all published genome linkage screens in multiple sclerosis and thereby performed a linkage analysis including 719 families studied with a weighted average of 359 microsatellite markers per family providing an average marker separation of 10.2 cM.
Journal ArticleDOI
Fine Mapping of the Chromosome 12 Late-Onset Alzheimer Disease Locus: Potential Genetic and Phenotypic Heterogeneity
William K. Scott,Janet M. Grubber,P. M. Conneally,Gary W. Small,Christine M. Hulette,Carolyn Rosenberg,Ann M. Saunders,A. D. Roses,A. D. Roses,Jonathan L. Haines,Margaret A. Pericak-Vance +10 more
TL;DR: The results indicate that the chromosome 12 locus acts independently of APOE to increase the risk of late-onset familial AD and that it may be associated with the DLB variant of AD.