J
Jonathan L. Haines
Researcher at Case Western Reserve University
Publications - 463
Citations - 44478
Jonathan L. Haines is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 100, co-authored 463 publications receiving 40225 citations. Previous affiliations of Jonathan L. Haines include John P. Hussman Institute for Human Genomics & Bascom Palmer Eye Institute.
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Journal ArticleDOI
Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems.
Laura J. Rasmussen-Torvik,Sarah C. Stallings,Adam S. Gordon,Berta Almoguera,Melissa A. Basford,Suzette J. Bielinski,Ariel Brautbar,Murray H. Brilliant,David Carrell,John Connolly,David R. Crosslin,Kimberly F. Doheny,Carlos J. Gallego,Omri Gottesman,Daniel Seung Kim,Kathleen A. Leppig,Rongling Li,Simon Lin,Shannon Manzi,Ana R. Mejia,Jennifer A. Pacheco,Vivian Pan,Jyotishman Pathak,Cassandra Perry,Josh F. Peterson,Cynthia A. Prows,James D. Ralston,Luke V. Rasmussen,Marylyn D. Ritchie,Senthilkumar Sadhasivam,Senthilkumar Sadhasivam,Stuart A. Scott,Maureen E. Smith,Aida Vega,Alexander A. Vinks,Alexander A. Vinks,Simona Volpi,Wendy A. Wolf,Erwin P. Bottinger,Rex L. Chisholm,Christopher G. Chute,Jonathan L. Haines,John B. Harley,John B. Harley,Brendan J. Keating,Ingrid A. Holm,Ingrid A. Holm,Iftikhar J. Kullo,Gail P. Jarvik,Eric B. Larson,Teri A. Manolio,Catherine A. McCarty,Deborah A. Nickerson,Steven E. Scherer,Marc S. Williams,Dan M. Roden,Joshua C. Denny +56 more
TL;DR: The design and initial implementation of the eMERGE‐PGx project is described, including site‐specific project implementation and anticipated products, including genetic variant and phenotype data repositories, novel variant association studies, clinical decision support modules, clinical and process outcomes, approaches to managing incidental findings, and patient and clinician education methods.
Journal ArticleDOI
Incorporating language phenotypes strengthens evidence of linkage to autism
Yuki Bradford,Jonathan L. Haines,Holli B. Hutcheson,Marybeth Gardiner,Terry A. Braun,Val C. Sheffield,Tom Cassavant,Wen Huang,Kai Wang,Veronica J. Vieland,Susan E. Folstein,Susan L. Santangelo,Joseph Piven +12 more
TL;DR: It is tentatively concluded that there may be more than one autism susceptibility locus related to language development, and the linkage signals obtained are mainly attributable to the subgroup of families in which both probands had language delay.
Journal ArticleDOI
Functional Candidate Genes in Age-Related Macular Degeneration: Significant Association with VEGF, VLDLR, and LRP6
Jonathan L. Haines,Nathalie Schnetz-Boutaud,Silke Schmidt,William K. Scott,Anita Agarwal,Eric A. Postel,Lana M. Olson,Shannon J. Kenealy,Michael A. Hauser,John R. Gilbert,Margaret A. Pericak-Vance +10 more
TL;DR: Test results suggest that LRP6, VEGF, and VLDLR may play a role in the risk of developing AMD, and genetic variation in five of these genes (IL1A, CKB, A2M, MGST1, and DCP1) is unlikely to explain a significant fraction of the risk
Journal ArticleDOI
Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study.
Lisa F. Barcellos,Lisa F. Barcellos,Lisa F. Barcellos,Brinda B. Kamdar,Patricia P. Ramsay,Cari DeLoa,Robin R. Lincoln,Stacy J. Caillier,Silke Schmidt,Jonathan L. Haines,Margaret A. Pericak-Vance,Jorge R. Oksenberg,Stephen L. Hauser +12 more
TL;DR: The presence of various immune disorders in families with several members with multiple sclerosis suggests that the disease might arise on a background of a generalised susceptibility to autoimmunity.
Journal ArticleDOI
Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases
Giovanni Coppola,Subashchandrabose Chinnathambi,Jason Lee,Beth A. Dombroski,Matt Baker,Alexandra I. Soto-Ortolaza,Suzee E. Lee,Eric Klein,Alden Y. Huang,Renee L. Sears,Jessica Lane,Anna Karydas,Robert O. Kenet,Jacek Biernat,Li-San Wang,Carl W. Cotman,Charles DeCarli,Allan I. Levey,John M. Ringman,Mario F. Mendez,Helena C. Chui,Isabelle Le Ber,Isabelle Le Ber,Alexis Brice,Alexis Brice,Michelle K. Lupton,Elisavet Preza,Simon Lovestone,John Powell,Neill R. Graff-Radford,Ronald C. Petersen,Bradley F. Boeve,Carol F. Lippa,Eileen H. Bigio,Ian R. A. Mackenzie,Elizabeth Finger,Andrew Kertesz,Richard J. Caselli,Marla Gearing,Jorge L. Juncos,Bernardino Ghetti,Salvatore Spina,Yvette Bordelon,Wallace W. Tourtellotte,Matthew P. Frosch,Jean Paul Vonsattel,Chris Zarow,Thomas G. Beach,Roger L. Albin,Andrew P. Lieberman,Virginia M.-Y. Lee,John Q. Trojanowski,Vivianna M. Van Deerlin,Thomas D. Bird,Douglas Galasko,Eliezer Masliah,Charles L. White,Juan C. Troncoso,Didier Hannequin,Adam L. Boxer,Michael D. Geschwind,Satish Kumar,Eva Maria Mandelkow,Zbigniew K. Wszolek,Ryan J. Uitti,Dennis W. Dickson,Jonathan L. Haines,Richard Mayeux,Margaret A. Pericak-Vance,Lindsay A. Farrer,Liana G. Apostolova,Steven E. Arnold,Clinton T. Baldwin,Robert Barber,M. Michael Barmada,Thomas G. Beach,Gary W. Beecham,Duane Beekly,David A. Bennett,Deborah Blacker,James D. Bowen,A. Boxer,James R. Burke,Jacqueline L. Buros,Joseph D. Buxbaum,Nigel J. Cairns,Laura B. Cantwell,Chuanhai Cao,Christopher S. Carlson,Regina M. Carney,Minerva M. Carrasquillo,Steven L. Carroll,David G. Clark,Jason J. Corneveaux,Paul K. Crane,Carlos Cruchaga,Jeffrey L. Cummings,Philip L. De Jager,Philip L. De Jager,Charles C. DeCarli,Steven T. DeKosky,F. Yesim Demirci,Ramon Diaz-Arrastia,Malcolm B. Dick,Ranjan Duara,William G. Ellis,Nilufer Ertekin-Taner,Denis A. Evans,Kelley Faber,Kenneth B. Fallon,Martin R. Farlow,Steven H. Ferris,Tatiana Foroud,Paul Gallins,Mary Ganguli,Daniel H. Geschwind,John R. Gilbert,Sid Gilman,Bruno Giordani,Jonathan D. Glass,Alison Goate,Neil Graff-Radford,Robert C. Green,John H. Growdon,Hakon Hakonarson,Ronald L. Hamilton,John Hardy,Lindy E. Harrell,Elizabeth Head,Lawrence S. Honig,Matthew J. Huentelman,Christine M. Hulette,Bradley T. Hyman,Gail P. Jarvik,Gregory A. Jicha,Lee-Way Jin,Nancy Johnson,Gyungah Jun,M. Ilyas Kamboh,Jason Karlawish,A. Karydas,John S. K. Kauwe,Jeffrey Kaye,Ronald C. Kim,Edward H. Koo,Neil W. Kowall,Patricia L. Kramer,Walter A. Kukull,James J. Lah,Eric B. Larson,Oscar L. Lopez,Kathryn L. Lunetta,Wendy J. Mack,Daniel C. Marson,Eden R. Martin,Frank Martiniuk,Deborah C. Mash,Wayne C. McCormick,Susan M. McCurry,Andrew McDavid,Ann C. McKee,M.-Marsel Mesulam,Bruce L. Miller,Carol A. Miller,Joshua W. Miller,Thomas J. Montine,John C. Morris,Amanda J. Myers,Adam C. Naj,Petra Nowotny,Joseph E. Parisi,Daniel P. Perl,Elaine R. Peskind,Wayne W. Poon,Huntington Potter,Joseph F. Quinn,Ashok Raj,Ruchita Rajbhandary,Murray A. Raskind,Eric M. Reiman,Barry Reisberg,Christiane Reitz,Erik D. Roberson,Ekaterina Rogaeva,Roger N. Rosenberg,Mary Sano,Andrew J. Saykin,Andrew J. Saykin,Julie A. Schneider,Lon S. Schneider,William W. Seeley,Michael L. Shelanski,Michael A. Slifer,Charles D. Smith,Joshua A. Sonnen,Peter St George-Hyslop,Peter St George-Hyslop,Robert S. Stern,Rudolph E. Tanzi,Debby W. Tsuang,Badri N. Vardarajan,Harry V. Vinters,Jean Paul G. Vonsattel,Sandra Weintraub,Kathleen A. Welsh-Bohmer,Jennifer Williamson,Randall L. Woltjer,Steven G. Younkin,Owen A. Ross,Rosa Rademakers,Gerard D. Schellenberg,Eckhard Mandelkow +211 more
TL;DR: These data provide the first genetic evidence and functional studies supporting the role of MAPT p.A152T as a rare risk factor for both FTD-s and AD and the concept that rare variants can increase the risk for relatively common, complex neurodegenerative diseases is suggested.