J
Jonathan L. Haines
Researcher at Case Western Reserve University
Publications - 463
Citations - 44478
Jonathan L. Haines is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 100, co-authored 463 publications receiving 40225 citations. Previous affiliations of Jonathan L. Haines include John P. Hussman Institute for Human Genomics & Bascom Palmer Eye Institute.
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Journal ArticleDOI
Confronting complexity in late-onset Alzheimer disease: Application of two-stage analysis approach addressing heterogeneity and epistasis
Tricia A. Thornton-Wells,Jason H. Moore,Eden R. Martin,Margaret A. Pericak-Vance,Jonathan L. Haines +4 more
TL;DR: A new comprehensive statistical and computational strategy for identifying the missing link between genotype and phenotype has been proposed, which emphasizes the need to address heterogeneity in the first stage of any analysis and gene‐gene interactions in the second stage.
Journal ArticleDOI
PCDH11X variation is not associated with late-onset Alzheimer disease susceptibility.
Gary W. Beecham,Adam C. Naj,John R. Gilbert,Jonathan L. Haines,Joseph D. Buxbaum,Margaret A. Pericak-Vance +5 more
TL;DR: It is found that association between late-onset Alzheimer disease and the PCDH11X polymorphisms in the authors' dataset of 889 cases and 850 controls is not as strong or generalized as hypothesized earlier.
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Association of TREM2 variants with Alzheimer's disease in African-Americans: For the Alzheimer's Disease Genetics Consortium (ADGC)
Christiane Reitz,Gyungah Jun,Adam C. Naj,Badri N. Vardarajan,Li-San Wang,Eric B. Larson,Neill R. Graff-Radford,Denis A. Evans,Philip L. De Jager,Paul K. Crane,Joseph D. Buxbaum,Nilufer Ertekin-Taner,Mark W. Logue,Robert Green,Laura B. Cantwell,Danielle Fallin,Jennifer J. Manly,Kathryn L. Lunetta,Ilyas Kamboh,Oscar L. Lopez,David A. Bennett,Kathleen S. Hall,Alison Goate,Goldie S. Byrd,Walter A. Kukull,Tatiana Foroud,Jonathan L. Haines,Lindsay A. Farrer,Margaret A. Pericak-Vance,Gerard D. Schellenberg,Richard Mayeux +30 more
TL;DR: Reitz et al. as mentioned in this paper published a report on the Association of TREM2 VARIANTS with ALZHEIMER's DISEASE in AFRICAN-AMERICANS.
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Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project.
Elizabeth E. Blue,Joshua C. Bis,Michael O. Dorschner,Debby W. Tsuang,Debby W. Tsuang,Sandra Barral,Gary W. Beecham,Jennifer E. Below,William S. Bush,Mariusz Butkiewicz,Carlos Cruchaga,Anita L. DeStefano,Lindsay A. Farrer,Alison Goate,Jonathan L. Haines,Jim Jaworski,Gyungah Jun,Brian W. Kunkle,Amanda B. Kuzma,Jenny Lee,Kathryn L. Lunetta,Yiyi Ma,Eden R. Martin,Adam C. Naj,Alejandro Q. Nato,Patrick A. Navas,Hiep Nguyen,Christiane Reitz,Dolly Reyes,William J Salerno,Gerard D. Schellenberg,Sudha Seshadri,Harkirat Sohi,Timothy A. Thornton,Otto Valadares,Cornelia M. van Duijn,Badri N. Vardarajan,Li-San Wang,Eric Boerwinkle,Eric Boerwinkle,Josée Dupuis,Margaret A. Pericak-Vance,Richard Mayeux,Ellen M. Wijsman +43 more
TL;DR: Evidence of co-segregation and associations between variants in dementia genes and clinically diagnosed AD within the ADSP is described and pathogenic variants within dementia genes were predominantly rare and conserved coding changes.
Journal ArticleDOI
Using the PhenX Toolkit to Add Standard Measures to a Study, Unit 1.21
Tabitha Hendershot,Huaqin Pan,Jonathan L. Haines,William R. Harlan,Heather Junkins,Erin M. Ramos,Carol Hamilton +6 more
TL;DR: The PhenX (consensus measures for Phenotypes and eXposures) Toolkit offers high‐quality, well‐established measures of phenotypes and exposures for use by the scientific community.