J
Jonathan L. Haines
Researcher at Case Western Reserve University
Publications - 463
Citations - 44478
Jonathan L. Haines is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 100, co-authored 463 publications receiving 40225 citations. Previous affiliations of Jonathan L. Haines include John P. Hussman Institute for Human Genomics & Bascom Palmer Eye Institute.
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Journal ArticleDOI
A common variant near TGFBR3 is associated with primary open angle glaucoma
Zheng Li,R. Rand Allingham,Masakazu Nakano,Liyun Jia,Yuhong Chen,Yoko Ikeda,Baskaran Mani,Li Jia Chen,Changwon Kee,David F. Garway-Heath,Sarangapani Sripriya,Nobuo Fuse,Khaled K. Abu-Amero,Khaled K. Abu-Amero,Chukai Huang,Prasanthi Namburi,Kathryn P. Burdon,Kathryn P. Burdon,Shamira A. Perera,Shamira A. Perera,Puya Gharahkhani,Ying Lin,Morio Ueno,Mineo Ozaki,Takanori Mizoguchi,SR Krishnadas,Essam A. Osman,Mei Chin Lee,Anita S Y Chan,Liza-Sharmini Ahmad Tajudin,Tan Do,Aurelien Goncalves,Pascal Reynier,Hong Zhang,Rupert R A Bourne,David Goh,David C Broadway,Rahat Husain,Anil Negi,Daniel H. Su,Ching-Lin Ho,Augusto Azuara Blanco,Christopher Kai-shun Leung,Tina T. Wong,Tina T. Wong,Azhany Yakub,Yutao Liu,Yutao Liu,Monisha E. Nongpiur,Jong Chul Han,Do Nhu Hon,Balekudaru Shantha,Bowen Zhao,Jinghong Sang,Nihong Zhang,Ryuichi Sato,Kengo Yoshii,Songhomita Panda-Jonas,Allison E. Ashley Koch,Leon W. Herndon,Sayoko E. Moroi,Pratap Challa,Jia Nee Foo,Jin-Xin Bei,Yi Xin Zeng,Cameron P. Simmons,Tran Nguyen Bich Chau,Philomenadin Ferdinamarie Sharmila,Merwyn Chew,Blanche Lim,Pansy O.S. Tam,Elaine Chua,Xiao Yu Ng,Victor H. K. Yong,Yaan Fun Chong,Wee Yang Meah,Saravanan Vijayan,Sohn Seongsoo,Wang Xu,Yik Ying Teo,Yik Ying Teo,Jessica N. Cooke Bailey,Jae H. Kang,Jonathan L. Haines,Ching-Yu Cheng,Seang-Mei Saw,E-Shyong Tai,Julia E. Richards,Robert Ritch,Douglas E. Gaasterland,Louis R. Pasquale,Louis R. Pasquale,Jianjun Liu,Jost B. Jonas,Dan Milea,Dan Milea,Ronnie George,Saleh A. Al-Obeidan,Kazuhiko Mori,Stuart MacGregor,Alex W. Hewitt,Alex W. Hewitt,Christopher A. Girkin,Mingzhi Zhang,Periasamy Sundaresan,Lingam Vijaya,David A. Mackey,David A. Mackey,Tien Yin Wong,Jamie E Craig,Xinghuai Sun,Shigeru Kinoshita,Janey L. Wiggs,Chiea Chuen Khor,Zhenglin Yang,Zhenglin Yang,Chi Pui Pang,Ningli Wang,Michael A. Hauser,Kei Tashiro,Tin Aung,Eranga N. Vithana +121 more
TL;DR: Exome Array analysis on POAG cases and controls confirmed strong evidence of association at CDKN2B-AS1 and observed one SNP showing significant association to POAG, which has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio.
Posted ContentDOI
The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibility
Nikolaos A. Patsopoulos,Sergio E. Baranzini,Adam Santaniello,Shoostari P,Chris Cotsapas,Wong G,Ashley Beecham,Tojo James,Replogle J,Ioannis S. Vlachos,Cristin McCabe,Tune H. Pers,Brandes A,Charles C. White,Brendan T. Keenan,Maria Cimpean,Winn P,Panteliadis I,Robbins A,Till F. M. Andlauer,Zarzycki O,Bénédicte Dubois,An Goris,Helle Bach Søndergaard,Finn Sellebjerg,Per Soelberg Sørensen,Henrik Ullum,Thoerner Lw,Janna Saarela,Rebeix Ic,Damotte,Bertrand Fontaine,Noel Lg,Mark Lathrop,Sandra Vukusik,Achim Berthele,Biberacher,Dorothea Buck,Christiane Gasperi,Christiane Graetz,Grummel,B. Hemmer,M.-M. Hoshi,Benjamin Knier,Thomas Korn,Christina M. Lill,Felix Luessi,Mark Mühlau,Frauke Zipp,Efthimios Dardiotis,Cristina Agliardi,Amoroso A,Nadia Barizzone,Benedetti M,Luisa Bernardinelli,Paola Cavalla,Ferdinando Clarelli,G. Comi,Daniele Cusi,Federica Esposito,Laura Ferrè,Daniela Galimberti,Clara Guaschino,Maurizio Leone,Martinelli,Moiola L,Marco Salvetti,Melissa Sorosina,Domizia Vecchio,Andrea Zauli,Silvia Santoro,Zuccalà M,Julia Y Mescheriakova,Duijn Cv,Steffan D. Bos,Elisabeth Gulowsen Celius,Anne Spurkland,Manuel Comabella,Xavier Montalban,Lars Alfredsson,Izaura Lima Bomfim,David Gomez-Cabrero,Jan Hillert,Maja Jagodic,M Lindén,Fredrik Piehl,Ilijas Jelcic,Roland Martin,Mireia Sospedra,Amie Baker,Maria Ban,Clive Hawkins,Hysi P,Seema Kalra,Fredrik Karpe,Jyoti Khadake,Genevieve Lachance,Molyneux P,Megan C Neville,J W Thorpe,Elizabeth M. Bradshaw,Stacy J. Caillier,Peter A. Calabresi,B. Cree,Anne H. Cross,Mary F. Davis,Bakker Pd,Silvia Delgado,Marieme Dembele,Keith R Edwards,Kathryn C. Fitzgerald,Frohlich I,Pierre-Antoine F. D. Gourraud,Jonathan L. Haines,Hakon Hakonarson,Dorlan J. Kimbrough,Noriko Isobe,Ioanna Konidari,Ellen Lathi,Marcus C. S. Lee,Taibo Li,An D,Zimmer A,Lo A,Lohith Madireddy,Clara P. Manrique,Mitja Mitrovic,Marta Olah,Ellis Patrick,Margaret A. Pericak-Vance,Laura Piccio,Cathy Schaefer,Howard L. Weiner,Kasper Lage,A Compston,David A. Hafler,Hanne F. Harbo,Stephen L. Hauser,Graeme J. Stewart,Sandra D'Alfonso,Giorgos M. Hadjigeorgiou,Bruce V. Taylor,Lisa F. Barcellos,David R. Booth,Rogier Q. Hintzen,Ingrid Kockum,Filippo Martinelli-Boneschi,Jacob L. McCauley,Jorge R. Oksenberg,Annette Bang Oturai,Stephen Sawcer,Ivinson A,Tommy Olsson,Phil De Jager,Murray L. Barclay,Laurent Peyrin-Biroulet,Mathias Chamaillard,Colombe J,Cottone M,Croft A,Renata D'Incà,Jonas Halfvarson,Hanigan K,Paul Henderson,Paul Henderson,Jean-Pierre Hugot,Jean-Pierre Hugot,Karban A,Nicholas A. Kennedy,Khan Ma,Marc Lémann,Arie Levine,Massey D,Monica Milla,Grant W. Montgomery,Evelyn Ng Sm,I. Oikonomou,Harald Peeters,Deborah D. Proctor,Jean-François Rahier,Roberts R,Paul Rutgeerts,Frank Seibold,Stronati L,Taylor Km,Törkvist L,Ublick K,Johan Van Limbergen,Gossum Av,Vatn Mh,Zhang H,Zhang W +191 more
TL;DR: While MS is most likely initially triggered by perturbation of peripheral immune responses the functional responses of microglia and other brain cells are also altered and may have a role in targeting an autoimmune process to the central nervous system.
Journal ArticleDOI
Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity.
Marylyn D. Ritchie,David W. Haas,Alison A. Motsinger,John P. Donahue,Huso Erdem,Stephen Raffanti,Peter F Rebeiro,Alfred L. George,Richard B. Kim,Jonathan L. Haines,Timothy R. Sterling +10 more
TL;DR: This nested case-control study examined relationships between MDR1, CYP2B6, and CYP3A4 variants and hepatotoxicity during antiretroviral therapy with either efavirenz- or nevirapine-containing regimens.
Journal ArticleDOI
Comprehensive search for Alzheimer disease susceptibility loci in the APOE region
Gyungah Jun,Badri N. Vardarajan,Jacqueline L. Buros,Chang En Yu,Michele Hawk,Beth A. Dombroski,Paul K. Crane,Eric B. Larson,Richard Mayeux,Jonathan L. Haines,Kathryn L. Lunetta,Margaret A. Pericak-Vance,Gerard D. Schellenberg,Lindsay A. Farrer +13 more
TL;DR: APOE alleles ε2, ε3, and ε4 account for essentially all the inherited risk of AD associated with this region, and other variants including a poly-T track in TOMM40 are not independent risk or AAO loci.
Journal ArticleDOI
DNA linkage analysis of X chromosome-linked chronic granulomatous disease
Robert L. Baehner,L M Kunkel,Anthony P. Monaco,Jonathan L. Haines,P. M. Conneally,Charles Palmer,Nyla A. Heerema,Stuart H. Orkin +7 more
TL;DR: Using cloned, polymorphic DNA probes, a linkage analysis within CGD families that suggests a more proximal location (Xp21) for the X chromosome CGD locus should facilitate molecular cloning of the CGD gene and molecular dissection of the phagocyte oxidase system.