J
Jonathan L. Haines
Researcher at Case Western Reserve University
Publications - 463
Citations - 44478
Jonathan L. Haines is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 100, co-authored 463 publications receiving 40225 citations. Previous affiliations of Jonathan L. Haines include John P. Hussman Institute for Human Genomics & Bascom Palmer Eye Institute.
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Journal ArticleDOI
Identification of rare noncoding sequence variants in gamma-aminobutyric acid A receptor, alpha 4 subunit in autism spectrum disorder.
Anthony J. Griswold,Derek J. Van Booven,Michael L. Cuccaro,Jonathan L. Haines,John R. Gilbert,Margaret A. Pericak-Vance +5 more
TL;DR: This study comprehensively re-sequenced the entire protein coding and noncoding portions of the gene and putative regulatory sequences in 82 ASD individuals and 55 developmentally typical pediatric controls, finding only a single common, coding variant, and no association of any single marker or set of variants with ASD.
Journal Article
The heritability of choroidal thickness in the Amish
Margaret A. Pericak-Vance,Rebecca J. Sardell,Muneeswar Gupta Nittala,Larry D. Adams,Renee Laux,Debra Dana,William K. Scott,Srinivas R. Sadda,Dwight Stambolian,Jonathan L. Haines +9 more
TL;DR: In this article, the heritability of choroidal thickness and its relationship to age-related macular degeneration (AMD) was evaluated using ocular coherence tomography (OCT) and fundus photography.
Journal ArticleDOI
Microduplications in an autism multiplex family narrow the region of susceptibility for developmental disorders on 15q24 and implicate 7p21.
Holly N. Cukier,Daria Salyakina,Sarah F. Blankstein,Joycelyn L. Robinson,Stephanie Sacharow,Deqiong Ma,Harry H. Wright,Ruth K. Abramson,Ramkumar Menon,Scott M. Williams,Jonathan L. Haines,Michael L. Cuccaro,John R. Gilbert,Margaret A. Pericak-Vance +13 more
TL;DR: Autistic first cousins who carry two microduplications concordant with disease are reported, which are the smallest duplication in the region to result in a neuropsychiatric disorder and may contribute to the complex etiology of autism spectrum disorders.
Journal ArticleDOI
Sorcs1 Alters APP Processing and Variants may Increase Alzheimer's Disease Risk
Christiane Reitz,Shinya Tokuhiro,Lorraine N. Clark,Christopher Conrad,Jean-Paul Vonsattel,Raphael Lantigua,Martin Medrano,Irene Simkin,Jonathan L. Haines,Margaret A. Pericak-Vance,Lindsay A. Farrer,Joseph H. Lee,Ekaterina Rogaeva,Peter St George-Hyslop,Richard Mayeux +14 more
TL;DR: Results indicate that even poorly resourced rural residential care facilities can benefit from micro-training in supporting the introduction of evidence-based practice and the value of linking messages to key quality and accreditation documents is important.