J
Jonathan L. Haines
Researcher at Case Western Reserve University
Publications - 463
Citations - 44478
Jonathan L. Haines is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 100, co-authored 463 publications receiving 40225 citations. Previous affiliations of Jonathan L. Haines include John P. Hussman Institute for Human Genomics & Bascom Palmer Eye Institute.
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Journal ArticleDOI
Genome- and Phenome-Wide Analyses of Cardiac Conduction Identifies Markers of Arrhythmia Risk
Marylyn D. Ritchie,Joshua C. Denny,Rebecca L. Zuvich,Dana C. Crawford,Jonathan S. Schildcrout,Lisa Bastarache,Andrea H. Ramirez,Jonathan D. Mosley,Jill M. Pulley,Melissa A. Basford,Yuki Bradford,Luke V. Rasmussen,Jyotishman Pathak,Christopher G. Chute,Iftikhar J. Kullo,Catherine A. McCarty,Rex L. Chisholm,Abel N. Kho,Christopher S. Carlson,Eric B. Larson,Gail P. Jarvik,Nona Sotoodehnia,Teri A. Manolio,Rongling Li,Daniel R. Masys,Daniel R. Masys,Jonathan L. Haines,Dan M. Roden +27 more
TL;DR: The phenome-wide association study approach implicated sodium channel variants modulating QRS duration in subjects without cardiac disease as predictors of subsequent arrhythmias and concluded that DNA biobanks coupled to electronic medical records may allow broad interrogation of the longitudinal incidence of disease associated with genetic variants.
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Rapidly progressive Alzheimer's disease features distinct structures of amyloid-β.
Mark L. Cohen,Chae Kim,Tracy Haldiman,Mohamed ElHag,Prachi Mehndiratta,Termsarasab Pichet,Frances M. Lissemore,Michelle Shea,Yvonne Cohen,Wei Chen,Janis Blevins,Brian S. Appleby,Krystyna Surewicz,Witold K. Surewicz,Martha Sajatovic,Curtis Tatsuoka,Shulin Na Zhang,Ping Mayo,Mariusz Butkiewicz,Jonathan L. Haines,Alan J. Lerner,Jiri G. Safar +21 more
TL;DR: Alzheimer's disease exhibits a wide spectrum of amyloid-β42 structural states and imply the existence of prion-like conformational strains, suggesting different conformers may play an important role in the pathogenesis of distinct Alzheimer's disease phenotypes.
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Whole-Exome Sequencing Links a Variant in DHDDS to Retinitis Pigmentosa
Stephan Züchner,Julia E. Dallman,Rong Wen,Gary W. Beecham,Adam C. Naj,Amjad Farooq,Martin A. Kohli,Patrice L. Whitehead,William Hulme,Ioanna Konidari,Yvonne J. K. Edwards,Guiqing Cai,Inga Peter,David Seo,Joseph D. Buxbaum,Jonathan L. Haines,Susan H. Blanton,Juan Young,Eduardo C. Alfonso,Jeffery M. Vance,Byron L. Lam,Margaret A. Pericak-Vance +21 more
TL;DR: The findings demonstrate the power of exome sequencing linked to functional studies when faced with challenging study designs and link RP to the pathways of N-linked glycosylation, which promise new avenues for therapeutic interventions.
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Meta-analysis of the association between variants in SORL1 and Alzheimer disease.
Christiane Reitz,Rong Cheng,Ekaterina Rogaeva,Joseph H. Lee,Shinya Tokuhiro,Fanggeng Zou,Karolien Bettens,Kristel Sleegers,Eng-King Tan,Eng-King Tan,Ryo Kimura,Nobuto Shibata,Heii Arai,M. Ilyas Kamboh,Jonathan A. Prince,Wolfgang Maier,Matthias Riemenschneider,Michael John Owen,Denise Harold,Paul Hollingworth,Elena Cellini,Sandro Sorbi,Benedetta Nacmias,Masatoshi Takeda,Margaret A. Pericak-Vance,Jonathan L. Haines,Steven G. Younkin,Julie Williams,Christine Van Broeckhoven,Lindsay A. Farrer,Peter St. George Hyslop,Peter St. George Hyslop,Peter St. George Hyslop,Richard Mayeux +33 more
TL;DR: A comprehensive meta-analysis of all published and unpublished data from case-control studies for the SORL1 single-nucleotide polymorphisms provides confirmatory evidence that multiple SORP variants in distinct linkage disequilibrium blocks are associated with AD.
Journal ArticleDOI
Investigation of autism and GABA receptor subunit genes in multiple ethnic groups
Ann L. Collins,Deqiong Ma,Patrice L. Whitehead,Eden R. Martin,Harry H. Wright,Ruth K. Abramson,John P. Hussman,Jonathan L. Haines,Michael L. Cuccaro,John R. Gilbert,Margaret A. Pericak-Vance +10 more
TL;DR: Findings confirmed earlier findings, indicating GABRA4 and GABRB1 as genes contributing to autism susceptibility, extending the effect to multiple ethnic groups and suggesting seizures as a stratifying phenotype.