J
Jonathan L. Haines
Researcher at Case Western Reserve University
Publications - 463
Citations - 44478
Jonathan L. Haines is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 100, co-authored 463 publications receiving 40225 citations. Previous affiliations of Jonathan L. Haines include John P. Hussman Institute for Human Genomics & Bascom Palmer Eye Institute.
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Journal ArticleDOI
A genome-wide scan in an Amish pedigree with parkinsonism.
Stephen L. Lee,Deborah G. Murdock,Jacob L. McCauley,Yuki Bradford,Amy E. Crunk,Lynne L. McFarland,L. Jiang,T. Wang,Nathalie Schnetz-Boutaud,Jonathan L. Haines +9 more
TL;DR: The study of an eight generation Amish pedigree with apparent autosomal dominant parkinsonism with incomplete penetrance suggests that parkinsonistan in this pedigree is genetically complex, with contributions from several loci.
Journal ArticleDOI
Methods for analysis in pharmacogenomics: lessons from the Pharmacogenetics Research Network Analysis Group.
Balaji Srinivasan,Jinbo Chen,Cheng Cheng,David V. Conti,Shiwei Duan,Brooke L. Fridley,Xiangjun Gu,Jonathan L. Haines,Eric Jorgenson,Aldi T. Kraja,Jessica Lasky-Su,Lang Li,Andrei Rodin,Dai Wang,M. A. Province,Marylyn D. Ritchie +15 more
TL;DR: The goal is to introduce readers to the topics discussed at the workshop and provide a direction for future development of analysis tools and methods for analysis of pharmacogenomic data.
Journal ArticleDOI
Overview of Linkage Analysis in Complex Traits
TL;DR: This unit outlines the key concepts of complex disease, and how linkage analysis for complex traits differs from simple Mendelian traits, and describes how disease parameters such as prevalence, heritability estimates, and mode of inheritance should be considered before data is collected.
Journal ArticleDOI
Association of CYP1B1 Haplotypes and Breast Cancer Risk in Caucasian Women
Yifan Huang,Amy Trentham-Dietz,Montserrat Garcia-Closas,Polly A. Newcomb,Linda Titus-Ernstoff,John M. Hampton,Stephen J. Chanock,Jonathan L. Haines,Kathleen M. Egan +8 more
TL;DR: It is suggested that genetic variation in CYP1B1 has at most a minor influence on breast cancer susceptibility among Caucasian women.
Journal ArticleDOI
Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes.
Vincent Laville,Jae H. Kang,Clara C. Cousins,Adriana I Iglesias,Reka Nagy,Jessica N. Cooke Bailey,Robert P. Igo,Yeunjoo E. Song,Daniel I. Chasman,William G. Christen,Peter Kraft,Bernard Rosner,Bernard Rosner,Frank B. Hu,James F. Wilson,Puya Gharahkhani,Alex W. Hewitt,Alex W. Hewitt,David A. Mackey,Pirro G. Hysi,Christopher J Hammond,C.M. vanDuijn,C.M. vanDuijn,Jonathan L. Haines,Veronique Vitart,John H. Fingert,Michael A. Hauser,Hugues Aschard,Hugues Aschard,Janey L. Wiggs,Anthony P Khawaja,Stuart MacGregor,Louis R. Pasquale,UK Biobank +33 more
TL;DR: There was little rg between diabetes- and glaucoma-related traits and genetic correlations between corneal properties (CCT, CRF and CH) and POAG were low and non-significant, respectively.