J
Jonathan L. Haines
Researcher at Case Western Reserve University
Publications - 463
Citations - 44478
Jonathan L. Haines is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 100, co-authored 463 publications receiving 40225 citations. Previous affiliations of Jonathan L. Haines include John P. Hussman Institute for Human Genomics & Bascom Palmer Eye Institute.
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Journal ArticleDOI
Age at onset in two common neurodegenerative diseases is genetically controlled
Yi-Ju Li,William K. Scott,Dale J. Hedges,Fengyu Zhang,P. Craig Gaskell,Martha Nance,Ray L. Watts,Jean P. Hubble,William C. Koller,Rajesh Pahwa,Matthew B. Stern,Bradley C. Hiner,Joseph Jankovic,Fred H. Allen,Christopher G. Goetz,Frank L. Mastaglia,Jeffrey M. Stajich,Rachel A. Gibson,Lefkos T. Middleton,Ann M. Saunders,Burton L. Scott,Gary W. Small,Kristin K. Nicodemus,Allison D. Reed,Donald E. Schmechel,Kathleen A. Welsh-Bohmer,P. Michael Conneally,Allen D. Roses,John R. Gilbert,Jeffery M. Vance,Jonathan L. Haines,Margaret A. Pericak-Vance +31 more
TL;DR: The data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases.
Journal ArticleDOI
Mapping Multiple Sclerosis Susceptibility to the HLA-DR Locus in African Americans
Jorge R. Oksenberg,Lisa F. Barcellos,Bruce A.C. Cree,Sergio E. Baranzini,Teodorica L. Bugawan,Omar Khan,Robin R. Lincoln,Amy Swerdlin,Emmanuel Mignot,Ling Lin,Douglas S. Goodin,Henry A. Erlich,Silke Schmidt,Glenys Thomson,David Reich,Margaret A. Pericak-Vance,Jonathan L. Haines,Stephen L. Hauser +17 more
TL;DR: A selective association with HLA-DRB1*15 was revealed, indicating a primary role for the DRB1 locus in MS independent of DQB1*0602, and is unlikely to be solely explained by admixture, since a substantial proportion of the susceptibility chromosomes from African American patients with MS displayed haplotypes consistent with an African origin.
Journal ArticleDOI
Cardiac Sodium Channel (SCN5A) Variants Associated with Atrial Fibrillation
Dawood Darbar,Prince J. Kannankeril,Brian S. Donahue,Gayle Kucera,Tanya Stubblefield,Jonathan L. Haines,Alfred L. George,Dan M. Roden +7 more
TL;DR: The findings of the present study expand the clinical spectrum of disorders of the cardiac sodium channel to include AF and represent important progress toward molecular phenotyping and directed rather than empirical therapy for this common arrhythmia.
Journal ArticleDOI
Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22
Betsy A. Hosler,Teepu Siddique,Peter C. Sapp,Peter C. Sapp,Wen Sailor,Wen Sailor,Michael C. Huang,Michael C. Huang,Anwar Hossain,Jasper R. Daube,Martha Nance,Chaohong Fan,Jocelyn Kaplan,Wu Yen Hung,Diane McKenna-Yasek,Jonathan L. Haines,Margaret A. Pericak-Vance,H. Robert Horvitz,Robert H. Brown +18 more
TL;DR: Data suggest that a defective gene located in the chromosome 9q21-q22 region may be linked to ALS with FTD, a set of families in which persons develop both ALS and FTD or either ALS or FTD alone.
Journal ArticleDOI
An autosomal genomic screen for autism. Collaborative linkage study of autism.
Barrett S,Beck Jc,Raphael Bernier,Erica Bisson,Terry A. Braun,Thomas L. Casavant,Deb Childress,Susan E. Folstein,Melissa E. Garcia,Mary Beth Gardiner,Stephen E. Gilman,Jonathan L. Haines,Hopkins K,Rebecca Landa,Meyer Nh,Mullane Ja,Darryl Y. Nishimura,Pat Palmer,Joseph Piven,Purdy J,Susan L. Santangelo,Charles Searby,Singleton J,Susan L. Slager +23 more
TL;DR: The first stage of a two-stage genomic screen for autism was carried out on individuals affected with autism from 75 families ascertained through an affected sib-pair, with the strongest multipoint results for regions on chromosomes 13 and 7.