J
Jonathan L. Haines
Researcher at Case Western Reserve University
Publications - 463
Citations - 44478
Jonathan L. Haines is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 100, co-authored 463 publications receiving 40225 citations. Previous affiliations of Jonathan L. Haines include John P. Hussman Institute for Human Genomics & Bascom Palmer Eye Institute.
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Causal associations between potentially modifiable risk factors and the Alzheimer's phenome: A Mendelian randomization study
Shea J. Andrews,Brian Fulton-Howard,Paul F. O'Reilly,Lindsay A. Farrer,Jonathan L. Haines,Richard Mayeux,Adam C. Naj,Margaret A. Pericak-Vance,Gerard D. Schellenberg,Li-San Wang,Edoardo Marcora,Alison Goate +11 more
TL;DR: Demonstration of a causal relationship between blood pressure, cholesterol levels, BMI, depression, insomnia symptoms, physical activity and educational attainment on the AD phenome strongly support public health programs to educate the public about these preventable causes of AD.
Patent
Genetic variants increase the risk of age-related macular degeneration
Margaret A. Pericak-Vance,Jonathan L. Haines,Eric Postel,Anita Agarwal,Michael A. Hauser,Silke Schmidt,William K. Scott +6 more
TL;DR: In this paper, DNA sequencing of the complement factor II gene (CFII) within this haplotype revealed a coding variant, Y402II, that significantly increased the risk for AMD with odds ratios between 2.45 and 5.57.
Journal ArticleDOI
A Genome‐Wide Linkage Screen in the Amish with Parkinson Disease Points to Chromosome 6
Anna C. Cummings,Stephen L. Lee,Jacob L. McCauley,Lan Jiang,Amy E. Crunk,Lynne L. McFarland,Paul Gallins,Denise Fuzzell,Clare Knebusch,Charles E. Jackson,William K. Scott,Margaret A. Pericak-Vance,Jonathan L. Haines +12 more
TL;DR: Results support involvement of loci on chromosome 6 in the genetic etiology of PD, and an isolated founder population of Amish living in the Midwestern United States is undertaken, to further elucidate the genetic component.
Journal ArticleDOI
Pathway analysis by randomization incorporating structure-PARIS: an update.
Mariusz Butkiewicz,Jessica N. Cooke Bailey,Alex T. Frase,Scott M. Dudek,Brian L. Yaspan,Marylyn D. Ritchie,Sarah A. Pendergrass,Jonathan L. Haines +7 more
TL;DR: An update to the pathway enrichment analysis tool 'Pathway Analysis by Randomization Incorporating Structure (PARIS)' that determines aggregated association signals generated from genome-wide association study results.