J
Jonathan L. Haines
Researcher at Case Western Reserve University
Publications - 463
Citations - 44478
Jonathan L. Haines is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 100, co-authored 463 publications receiving 40225 citations. Previous affiliations of Jonathan L. Haines include John P. Hussman Institute for Human Genomics & Bascom Palmer Eye Institute.
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Journal ArticleDOI
Examination of association to autism of common genetic variationin genes related to dopamine.
B. M. Anderson,Nathalie Schnetz-Boutaud,Jacquelaine Bartlett,Harry H. Wright,Ruth K. Abramson,Michael L. Cuccaro,Jill Gilbert,Margaret A. Pericak-Vance,Jonathan L. Haines +8 more
TL;DR: It is demonstrated that common genetic variation within the tested genes located within this pathway at most play a minor to moderate role in overall autism pathogenesis.
Journal ArticleDOI
Successful aging shows linkage to chromosomes 6, 7, and 14 in the Amish.
Digna R. Velez Edwards,John Gilbert,Lan Jiang,Paul Gallins,Laura Caywood,Marilyn Creason,Denise Fuzzell,Clare Knebusch,Charles E. Jackson,Margaret A. Pericak-Vance,Jonathan L. Haines,William K. Scott +11 more
TL;DR: The Amish are genetically and socially isolated with homogeneous lifestyles, making them a suitable population for studying the genetics of SA, and DNA and measures of SA were collected on 214 cognitively intact Amish individuals over age 80.
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Lack of association between UBQLN1 and Alzheimer disease.
Michael A. Slifer,Eden R. Martin,Paola G. Bronson,C. Browning-Large,P.M. Doraiswamy,Kathleen A. Welsh-Bohmer,John R. Gilbert,Jonathan L. Haines,Margaret A. Pericak-Vance +8 more
TL;DR: The results suggest that UBQLN1 variants do not increase risk for AD in these data, and using age at onset (AAO) as a quantitative trait revealed a modest age modifying association; however, the results were inconsistent between the data sets.
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Confirmation of linkage of type 1 hereditary sensory neuropathy to human chromosome 9q22
Khemissa Bejaoui,Diane McKenna-Yasek,Betsy A. Hosler,E. Burns-Deater,L. M. Deater,Gilmore O'Neill,Jonathan L. Haines,Robert H. Brown +7 more
TL;DR: This study confirms linkage of a putative HSN-I gene to chromosome 9q22, considerably narrows the H SN-I locus, and provides a basis for identification of the HSN -I gene.
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DNA copy number variants of known glaucoma genes in relation to primary open-angle glaucoma.
Yutao Liu,Yutao Liu,Melanie E. Garrett,Brian L. Yaspan,Jessica N. Cooke Bailey,Stephanie Loomis,Murray H. Brilliant,Donald L. Budenz,William G. Christen,John H. Fingert,Douglas E. Gaasterland,Terry Gaasterland,Jae H. Kang,Richard K. Lee,Paul R. Lichter,Sayoko E. Moroi,Anthony Realini,Julia E. Richards,Joel S. Schuman,William K. Scott,Kuldev Singh,Arthur J. Sit,Douglas Vollrath,Robert N. Weinreb,Gadi Wollstein,Donald J. Zack,Kang Zhang,Margaret A. Pericak-Vance,Jonathan L. Haines,Louis R. Pasquale,Janey L. Wiggs,R. Rand Allingham,Allison E. Ashley-Koch,Michael A. Hauser +33 more
TL;DR: The CNV analysis of a large set of cases and controls revealed the presence of rare CNVs in known POAG susceptibility genes, suggesting that these rareCNVs may contribute to POAG pathogenesis and merit functional evaluation.