J
Jonathan L. Haines
Researcher at Case Western Reserve University
Publications - 463
Citations - 44478
Jonathan L. Haines is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 100, co-authored 463 publications receiving 40225 citations. Previous affiliations of Jonathan L. Haines include John P. Hussman Institute for Human Genomics & Bascom Palmer Eye Institute.
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Journal ArticleDOI
Novel mutation in the SPG3A gene in an African American family with an early onset of hereditary spastic paraplegia.
TL;DR: A novel mutation in the SPG3A gene is reported in an African American family with an infantile onset of autosomal dominant hereditary spastic paraplegia.
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The ubiquilin 1 gene and Alzheimer's disease.
TL;DR: It is shown that levels of thromboxane and prostacyclin were reduced with 100 mg of aspirin every other day; the expected increased risk of gastrointestinal bleeding, hemorrhagic stroke, nongastrointestinal bleeding, and peptic ulcer was observed; and the issue of the lowest effective dose in both women and men requires further research.
Journal ArticleDOI
Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma
Puya Gharahkhani,Kathryn P. Burdon,Jessica N. Cooke Bailey,Alex W. Hewitt,Matthew Law,Louis R. Pasquale,Jae H. Kang,Jonathan L. Haines,Emmanuelle Souzeau,Tiger Zhou,Owen M. Siggs,John Landers,Mona S Awadalla,Shiwani Sharma,Richard A. Mills,Bronwyn Ridge,David J. Lynn,Robert J Casson,Stuart L. Graham,Ivan Goldberg,Andrew White,Paul R. Healey,John R. Grigg,Mitchell Lawlor,Paul Mitchell,Jonathan B Ruddle,Michael Coote,Mark J Walland,Stephen Best,Andrea L Vincent,Jesse Gale,Graham L. Radford-Smith,Graham L. Radford-Smith,David C. Whiteman,Grant W. Montgomery,Grant W. Montgomery,Nicholas G. Martin,David A. Mackey,David A. Mackey,Janey L. Wiggs,Stuart MacGregor,Jamie E Craig,R. Rand Allingham,Murray H. Brilliant,Donald L. Budenz,John H. Fingert,Douglas E. Gaasterland,Terry Gaasterland,Lisa A Hark,Michael A. Hauser,Robert P. Igo,Peter Kraft,Richard K. Lee,Paul R. Lichter,Yutao Liu,S.E. Moroi,Margaret A. Pericak-Vance,Anthony Realini,Doug Rhee,Julia E. Richards,Robert Ritch,Joel S. Schuman,William K. Scott,Kuldev Singh,Arthur J. Sit,Douglas Vollrath,Gadi Wollstein,Donald J. Zack +67 more
TL;DR: This study is the first integrative study to combine genetic data from OAG and its correlated traits to identify new risk variants and genetic pathways, highlighting the future potential of combining geneticData from genetically-correlated eye traits for the purpose of gene discovery and mapping.
Journal ArticleDOI
The carnitine shuttle pathway is altered in patients with neovascular age-related macular degeneration
Sabrina L. Mitchell,Karan Uppal,Samantha M. Williamson,Ken Liu,L. Goodwin Burgess,ViLinh Tran,Allison C. Umfress,Kelli L. Jarrell,Jessica N. Cooke Bailey,Anita Agarwal,Margaret A. Pericak-Vance,Jonathan L. Haines,William K. Scott,Dean P. Jones,Milam A. Brantley +14 more
TL;DR: Multiple long-chain acylcarnitines that are part of the carnitine shuttle pathway were significantly increased in NV AMD patients compared to controls, suggesting that fatty acid metabolism may be involved in NVAMD pathophysiology.
Journal Article
Machado-Joseph Disease in Pedigrees of Azorean descent is Linked to Chromosome 14
P. St. George-Hyslop,Ekaterina Rogaeva,J. Huterer,T. Tsuda,J. Santos,Jonathan L. Haines,Karen Schlumpf,Evgeny I. Rogaev,Yan Liang,D. R. Crapper McLachlan,James L. Kennedy,J. Weissenbach,G. D. Billingsley,Diane W. Cox,Anthony E. Lang,J. R. Wherrett +15 more
TL;DR: Observations confirm the initial report of linkage of MJD to chromosome 14; suggest that MJD in Japanese and Azorean subjects may represent allelic or identical mutations at the same locus; and provide one possible explanation for the observed phenotypic heterogeneity in this disease.