J
Jonathan L. Haines
Researcher at Case Western Reserve University
Publications - 463
Citations - 44478
Jonathan L. Haines is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 100, co-authored 463 publications receiving 40225 citations. Previous affiliations of Jonathan L. Haines include John P. Hussman Institute for Human Genomics & Bascom Palmer Eye Institute.
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Journal ArticleDOI
CpG‐related SNPs in the MS4A region have a dose‐dependent effect on risk of late–onset Alzheimer disease
Yiyi Ma,Yiyi Ma,Gyungah Jun,Jaeyoon Chung,Xiaoling Zhang,Brian W. Kunkle,Adam C. Naj,Charles C. White,Charles C. White,David A. Bennett,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Richard Mayeux,Jonathan L. Haines,Margaret A. Pericak-Vance,Gerard D. Schellenberg,Lindsay A. Farrer,Kathryn L. Lunetta +18 more
TL;DR: The importance of CGS in AD is confirmed and the potential for creating a functional CpG dosage‐derived genetic score to predict AD risk is confirmed.
Journal ArticleDOI
Beyond proof of principle: new genes for Alzheimer's disease through collaboration.
TL;DR: Three genes, the amyloid precursor protein [APP] 2 and the presenilin 1 and 2 [PS1 and PS2] genes 3–5, were identified using the classical Mendelian positional cloning paradigm most prominently applied in the 1990’s.
Journal ArticleDOI
Reproducibility of qualitative assessment of drusen volume in eyes with age related macular degeneration.
Federico Corvi,Federico Corvi,Sowmya Srinivas,Muneeswar Gupta Nittala,Giulia Corradetti,Swetha Bindu Velaga,Dwight Stambolian,Jonathan L. Haines,Margaret A. Pericak-Vance,Srinivas R. Sadda +9 more
TL;DR: The ability of human graders to qualitatively assess drusen volume by inspection of OCT B-scans was evaluated and this approach may be useful in the assessment of risk for progression to late age-related macular degeneration.
Journal ArticleDOI
No association between SNP rs498055 on chromosome 10 and late-onset Alzheimer disease in multiple datasets.
Xueying Liang,Nathalie Schnetz-Boutaud,Jackie Bartlett,Melissa Allen,Harry E. Gwirtsman,Don Schmechel,Regina M. Carney,John R. Gilbert,Margaret A. Pericak-Vance,Jonathan L. Haines +9 more
TL;DR: It is concluded that rs498055 is not associated with an increased risk of LOAD and is consistent with a more recent negative association result that used family‐based association tests to examine the effect of this SNP in two family datasets.
Convergent genetic and expression data implicate immunity in Alzheimer's disease
Lesley Jones,Jean-Charles Lambert,Li-San Wang,Seung Hoan Choi,Denise Harold,Alexey Vedernikov,Valentina Escott-Price,Timothy Stone,Alexander Richards,Céline Bellenguez,Carla A. Ibrahim-Verbaas,Adam C. Naj,Rebecca Sims,Amy Gerrish,Gyungah Jun,Anita L. DeStefano,Joshua C. Bis,Gary W. Beecham,Benjamin Grenier-Boley,Giancarlo Russo,Tricia A. Thornton-Wells,Nicola Jones,Albert V. Smith,Vincent Chouraki,Charlene Thomas,M. Arfan Ikram,Diana Zelenika,Badri N. Vardarajan,Yoichiro Kamatani,Chiao-Feng Lin,Helena Schmidt,Brian W. Kunkle,Melanie L. Dunstan,Agustín Ruiz,Marie-Thérèse Bihoreau,Christiane Reitz,Florence Pasquier,Paul Hollingworth,Olivier Hanon,Annette L. Fitzpatrick,Joseph D. Buxbaum,Dominique Campion,Paul K. Crane,Tim Becker,Vilmundur Gudnason,Carlos Cruchaga,David Craig,Najaf Amin,Claudine Berr,Oscar L. Lopez,Philip L. De Jager,Vincent Deramecourt,Janet A. Johnston,Denis A. Evans,Simon Lovestone,Luc Letteneur,J. Kornhuber,Lluís Tárraga,David C. Rubinsztein,Gudny Eiriksdottir,Kristel Sleegers,Alison Goate,Nathalie Fievet,Matthew J. Huentelman,Michael Gill,Valur Emilsson,Kristelle Brown,M. Ilyas Kamboh,Lina Keller,Pascale Barberger-Gateau,Bernadette McGuinness,Eric B. Larson,Amanda J. Myers,Carole Dufouil,Stephen Todd,David Wallon,Seth Love,Patrick G. Kehoe,Ekaterina Rogaeva,John Gallacher,Peter St George-Hyslop,Jordi Clarimón,Alberti Lleὀ,Anthony Bayer,Debby W. Tsuang,Lei Yu,Magda Tsolaki,Paola Bossù,Gianfranco Spalletta,Petra Proitsi,John Collinge,Sandro Sorbi,Florentino Sanchez Garcia,Nick C. Fox,John Hardy,Maria Candida Deniz Naranjo,Cristina Razquin,P. Bosco,Robert Clarke,Carol Brayne,Daniela Galimberti,Michelangelo Mancuso,Susanne Moebus,Patrizia Mecocci,Maria Del Zompo,Wolfgang Maier,Harald Hampel,Alberto Pilotto,María J. Bullido,Francesco Panza,Paolo Caffarra,Benedetta Nacmias,John R. Gilbert,Manuel Mayhaus,Frank Jessen,Martin Dichgans,Lars Lannfelt,Hakon Hakonarson,Sabrina Pichler,Minerva M. Carrasquillo,Martin Ingelsson,Duane Beekly,Victoria Alavarez,Fanggeng Zou,Otto Valladares,Steven G. Younkin,Eliecer Coto,Kara L. Hamilton-Nelson,Ignacio Mateo,Michael John Owen,Kelley Faber,Palmi V. Jonsson,Onofre Combarros,Michael Conlon O'Donovan,Laura B. Cantwell,Hilkka Soininen,Deborah Blacker,Simon Mead,Thomas H. Mosley,David A. Bennett,Tamara B. Harris,Laura Fratiglioni,Clive Holmes,Renée F.A.G. de Bruijn,Peter Passmore,Thomas J. Montine,Karolien Bettens,Jerome I. Rotter,Alexis Brice,Kevin Morgan,Tatiana Foroud,Walter A. Kukull,Didier Hannequin,John Powell,Mike A. Nalls,Karen Ritchie,Kathryn L. Lunetta,John S. K. Kauwe,Eric Boerwinkle,Matthias Riemenschneider,Mercè Boada,Mikko Hiltunen,Eden R. Martin,Pau Pastor,Reinhold E. Schmidt,Dan Rujescu,Jean-François Dartigues,Richard Mayeux,Christophe Tzourio,Albert Hofman,Markus M. Nöthen,Caroline Graff,Bruce M. Psaty,Jonathan L. Haines,Mark Lathrop,Margaret A. Pericak-Vance,Lenore J. Launer,Lindsay A. Farrer,Cornelia M. van Duijn,Christine Van Broekhoven,Alfredo Ramirez,Gerard D. Schellenberg,Sudha Seshadri,Philippe Amouyel,Julie Williams,Peter Holmans +185 more
TL;DR: In this article, the authors extended these genetic data in a pathway analysis to identify the biology underlying the disease, and they found that late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP).