J
Joseph Loscalzo
Researcher at Brigham and Women's Hospital
Publications - 875
Citations - 79338
Joseph Loscalzo is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Nitric oxide & Platelet. The author has an hindex of 129, co-authored 828 publications receiving 71573 citations. Previous affiliations of Joseph Loscalzo include Veterans Health Administration & University of California, Los Angeles.
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Network Medicine: A Network-Based Approach to Human Disease
TL;DR: Advances in this direction are essential for identifying new disease genes, for uncovering the biological significance of disease-associated mutations identified by genome-wide association studies and full-genome sequencing, and for identifying drug targets and biomarkers for complex diseases.
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Biochemistry of nitric oxide and its redox-activated forms
TL;DR: The integration of this chemistry with current perspectives of NO biology illuminates many aspects of NO biochemistry, including the enzymatic mechanism of synthesis, the mode of transport and targeting in biological systems, the means by which its toxicity is mitigated, and the function-regulating interaction with target proteins.
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A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
Stuart A. Lipton,Yun-Beom Choi,Yun-Beom Choi,Zhuo Hua Pan,Zhuo Hua Pan,Sizheng Z. Lei,Sizheng Z. Lei,Huei-Sheng Vincent Chen,Huei-Sheng Vincent Chen,Nikolaus J. Sucher,Nikolaus J. Sucher,Joseph Loscalzo,Joseph Loscalzo,David J. Singel,Jonathan S. Stamler,Jonathan S. Stamler +15 more
TL;DR: It is reported that NO.-mediated neurotoxicity is engendered, at least in part, by reaction with superoxide anion (O.-2), apparently leading to formation of peroxynitrite (ONOO−), and not by NO.
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Endothelial Cells in Physiology and in the Pathophysiology of Vascular Disorders
Douglas B. Cines,Eleanor S. Pollak,Clayton A. Buck,Joseph Loscalzo,Guy A. Zimmerman,Rodger P. McEver,Jordan S. Pober,Timothy M. Wick,Barbara A. Konkle,Bradford S. Schwartz,Elliot S. Barnathan,Keith R. McCrae,Bruce A. Hug,Ann Marie Schmidt,David M. Stern +14 more
TL;DR: The membrane has long been viewed as an inert cellophane-like membrane that lines the circulatory system with its primary essential function being the maintenance of vessel wall permeability.
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Homocysteine and atherothrombosis
George N. Welch,Joseph Loscalzo +1 more
TL;DR: In 1969, McCully reported autopsy evidence of extensive arterial thrombosis and atherosclerosis in two children with elevated plasma homocyst(e)ine concentrations and homocysteine thiolactone, and it has recently become clear that hyperhomocyst (e)inemia is an independent risk factor.