Judith T. Lucas

TL;DR: It is demonstrated that the first IgM and IgG antibodies induced by transmitted HIV-1 are capable of binding virions but have little impact on acute-phase viremia at the timing and magnitude that they occur in natural infection.

TL;DR: The detailed measurements of the decline in multiple HIV-specific IgG3 responses simultaneous with persistent IgG1 responses during acute and recent HIV-1 infection could serve as markers for detection of incident HIV infection.

TL;DR: Allelic variants of the VH2-5 inferred germ line forms of the HIV-1 gp41 bNAb 2F5 are studied for their antigen binding affinities to gp41 linear peptide and conformational protein antigens, demonstrating a genetically determined trait that may affect host responses to HIV- 1 envelope epitopes recognized by broadly neutralizing antibodies and has implications for unmutated ancestor-based immunogen design.

TL;DR: Characterization of the functional properties of HIV-1 Env-specific IgA monoclonal antibodies from human vaccine clinical trials are critical toward understanding the capacity of the host immune response to block HIV-2 acquisition and the complex and diverse interactions of vaccine-elicited IgA with pathogens that depend on IgA fine specificity and form in the systemic circulation and mucosal compartments.