J
Julia Zeitlinger
Researcher at Stowers Institute for Medical Research
Publications - 64
Citations - 15872
Julia Zeitlinger is an academic researcher from Stowers Institute for Medical Research. The author has contributed to research in topics: Enhancer & RNA polymerase II. The author has an hindex of 32, co-authored 58 publications receiving 14655 citations. Previous affiliations of Julia Zeitlinger include Massachusetts Institute of Technology & University of Kansas.
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Journal ArticleDOI
Transcriptional Regulatory Networks in Saccharomyces cerevisiae
Tong Ihn Lee,Nicola J. Rinaldi,François Robert,Duncan T. Odom,Ziv Bar-Joseph,Georg K. Gerber,Nancy M. Hannett,Christopher T. Harbison,Craig M. Thompson,Itamar Simon,Julia Zeitlinger,Ezra G. Jennings,Heather L. Murray,D. Benjamin Gordon,Bing Ren,John J. Wyrick,Jean-Bosco Tagne,Thomas L. Volkert,Ernest Fraenkel,David K. Gifford,Richard A. Young +20 more
TL;DR: This work determines how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells, and identifies network motifs, the simplest units of network architecture, and demonstrates that an automated process can use motifs to assemble a transcriptional regulatory network structure.
Journal ArticleDOI
Polycomb complexes repress developmental regulators in murine embryonic stem cells
Laurie A. Boyer,Kathrin Plath,Kathrin Plath,Julia Zeitlinger,Tobias Brambrink,Lea Ann Medeiros,Tong Ihn Lee,Stuart S. Levine,Marius Wernig,Adriana Tajonar,Mridula K. Ray,George W. Bell,Arie P. Otte,Miguel Vidal,David K. Gifford,Richard A. Young,Rudolf Jaenisch +16 more
TL;DR: It is shown that PcG proteins directly repress a large cohort of developmental regulators in murine ES cells, the expression of which would otherwise promote differentiation, and dynamic repression of developmental pathways by Polycomb complexes may be required for maintaining ES cell pluripotency and plasticity during embryonic development.
Journal ArticleDOI
Transcriptional regulatory code of a eukaryotic genome
Christopher T. Harbison,D. Benjamin Gordon,Tong Ihn Lee,Nicola J. Rinaldi,Kenzie D MacIsaac,Timothy Danford,Nancy M. Hannett,Jean-Bosco Tagne,David B. Reynolds,Jane Yoo,Ezra G. Jennings,Julia Zeitlinger,Dmitry K. Pokholok,Manolis Kellis,Manolis Kellis,P. Alex Rolfe,Ken T. Takusagawa,Eric S. Lander,Eric S. Lander,David K. Gifford,David K. Gifford,Ernest Fraenkel,Richard A. Young,Richard A. Young +23 more
TL;DR: An initial map of yeast's transcriptional regulatory code is constructed by identifying the sequence elements that are bound by regulators under various conditions and that are conserved among Saccharomyces species.
Journal ArticleDOI
Genome-wide map of nucleosome acetylation and methylation in yeast.
Dmitry K. Pokholok,Christopher T. Harbison,Stuart S. Levine,Megan F. Cole,Nancy M. Hannett,Tong Ihn Lee,George W. Bell,Kimberly Walker,P. Alex Rolfe,Elizabeth Herbolsheimer,Julia Zeitlinger,Fran Lewitter,David K. Gifford,Richard A. Young +13 more
TL;DR: These maps take into account changes in nucleosome occupancy at actively transcribed genes and, in doing so, revise previous assessments of the modifications associated with gene expression, providing the foundation for further understanding the roles of chromatin in gene expression and genome maintenance.
Journal ArticleDOI
RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo.
Julia Zeitlinger,Alexander Stark,Manolis Kellis,Joung-Woo Hong,Sergei Nechaev,Karen Adelman,Michael Levine,Richard A. Young +7 more
TL;DR: It is proposed that Pol II stalling facilitates rapid temporal and spatial changes in gene activity during development and is highly enriched for developmental control genes, which are either repressed or poised for activation during later stages of embryogenesis.