Jürg Bähler

TL;DR: It is shown that cyclin-dependent kinase (CDK)-induced replication stress, resulting from Wee1 inactivation, is synthetic lethal with mutations disrupting dNTP homeostasis in fission yeast, and this findings support a ‘dNTP supply and demand’ model in which maintaining dN TPHomeostasis is essential to prevent replication catastrophe in response to CDK- induced replication stress.

TL;DR: It is shown for the first time that Int6CT acts to increase the transcriptional activity of Pap1, a highly conserved subunit of eukaryotic translation initiation factor 3 (eIF3) that has been reported to interact with subunits of the proteasome and the COP9 signalosome.

TL;DR: A set of strains designed to make swi5‐based mapping more efficient and more powerful are described, and it is determined that mod22‐1, a modifier of microtubule nucleation phenotypes, encodes a truncation allele of Swr 1, a chromatin‐remodelling factor involved in nucleosomal deposition of H2A.

TL;DR: Common and specialized roles of AMPK and Gsk3 in mediating TOR-dependent processes are revealed, indicating that AM PK and GSk3 act in parallel to inhibit TOR function in fission yeast.

TL;DR: It is shown that Cdk9 inhibition or H2Bub1 loss induces intragenic antisense transcription of ∼10% of fission yeast genes, with each perturbation affecting largely distinct subsets; ablation of both pathways de-represses antisensecription of over half the genome.