Jürg Bähler

TL;DR: It is shown that copy number variants (CNVs) frequently segregate within closely related clonal populations, are weakly linked to single nucleotide polymorphisms (SNPs), and show other genetic signals consistent with rapid turnover that have broad implications for evolution and for the understanding of quantitative traits including complex human diseases.

TL;DR: Low Pyk1 activity provided no growth advantage but stress tolerance, despite increased respiration, and the genetic tuning of glycolytic flux by a single-nucleotide change might reflect an adaptive trade-off in a species lacking pyruvate-kinase isoforms.

TL;DR: It is found that exposure to stress decreases the average damage from node removal, suggesting stress induces greater tolerance to loss of function mutations, and the shape of the damage distribution is changed upon stress.

TL;DR: The results reveal that the ASFV-RNAP undergoes transcript slippage at the 5’ end of transcription units that in a promoter sequence-specific manner results in the addition of 5‘-AT and 5�’-ATAT tails to mRNAs.

TL;DR: It is proposed that Ppk31 and SPBC409.08 may function together to modulate lifespan, thus linking Rim15/Ppk 31 with spermidine metabolism, and single and double allele replacement suggests that both variants, alone or combined, have subtle effects on cellular longevity.