J
Jürg Bähler
Researcher at University College London
Publications - 237
Citations - 24955
Jürg Bähler is an academic researcher from University College London. The author has contributed to research in topics: Schizosaccharomyces pombe & Gene. The author has an hindex of 67, co-authored 227 publications receiving 21327 citations. Previous affiliations of Jürg Bähler include University of Debrecen & European Bioinformatics Institute.
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Journal ArticleDOI
Failed gene conversion leads to extensive end processing and chromosomal rearrangements in fission yeast
Helen Tinline-Purvis,Andrew P. Savory,Jason K Cullen,Anoushka Davé,Jennifer Moss,Wendy L Bridge,Samuel Marguerat,Jürg Bähler,Jiannis Ragoussis,Richard Mott,Carol Walker,Timothy C. Humphrey +11 more
TL;DR: A genetic system is developed to investigate the mechanisms of DNA double‐strand break (DSB)‐induced extensive LOH, and its suppression, using a non‐essential minichromosome, Ch16, in fission yeast, and finds extensive Loh to arise from a new break‐induced mechanism of isochromosomesome formation.
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YOGY: a web-based, integrated database to retrieve protein orthologs and associated Gene Ontology terms
TL;DR: YOGY is a web-based resource for orthologous proteins from nine eukaryotic organisms that provides comprehensive, combined information on orthologs in other species using data from five independent resources: KOGs, Inparanoid, HomoloGene, OrthoMCL and a table of curated fission and budding yeast orthology.
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The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.
Sofia Aligianni,Daniel H. Lackner,Steffi Klier,Gabriella Rustici,Brian T. Wilhelm,Samuel Marguerat,Sandra Codlin,Alvis Brazma,Robertus A.M. de Bruin,Jürg Bähler +9 more
TL;DR: Yox1p is established as a new regulatory MBF component in fission yeast, which is transcriptionally induced by MBF and in turn inhibits MBF-dependent transcription.
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Autoregulation of ribosome biosynthesis by a translational response in fission yeast.
TL;DR: The results indicate that rmt3-null fission yeast compensate for the reduced levels of small ribosomal subunits by increasing the ribosome density, and likely the translation efficiency, of 40S Ribosomal protein-encoding mRNAs.
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Individual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast
TL;DR: Fission yeast CTD mutants in which single coding cues are subtracted from all consensus heptads to gauge the roles of the Tyr1, Ser2, Thr4, and Ser7 phosphoacceptors in gene expression highlight specific cellular gene expression programs that are responsive to distinct CTD cues.