J
Jürg Bähler
Researcher at University College London
Publications - 237
Citations - 24955
Jürg Bähler is an academic researcher from University College London. The author has contributed to research in topics: Schizosaccharomyces pombe & Gene. The author has an hindex of 67, co-authored 227 publications receiving 21327 citations. Previous affiliations of Jürg Bähler include University of Debrecen & European Bioinformatics Institute.
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Journal ArticleDOI
Widespread exon skipping triggers degradation by nuclear RNA surveillance in fission yeast.
Danny A. Bitton,Sophie R. Atkinson,Charalampos Rallis,Graeme C. Smith,David A. Ellis,Yuan Y.C. Chen,Michal Malecki,Sandra Codlin,Jean-François Lemay,Cristina Cotobal,François Bachand,Samuel Marguerat,Juan Mata,Jürg Bähler +13 more
TL;DR: RNA-seq data from 116 transcriptomes in fission yeast is analyzed, highlighting widespread but low frequency alternative or aberrant splicing events that are targeted by nuclear RNA surveillance.
Journal ArticleDOI
Mfc1 is a novel forespore membrane copper transporter in meiotic and sporulating cells.
Jude Beaudoin,Raphaël Ioannoni,Luis López-Maury,Jürg Bähler,Samia Ait-Mohand,Brigitte Guérin,Sheel C. Dodani,Christopher J. Chang,Simon Labbé +8 more
TL;DR: Analysis of DNA microarrays in the model yeast Schizosaccharomyces pombe revealed a novel meiosis-specific gene, termed mfc1+, that encodes a putative major facilitator superfamily-type transporter that serves to transport copper for accurate and timely meiotic differentiation under copper-limiting conditions.
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A CRISPR/Cas9-based method and primer design tool for seamless genome editing in fission yeast
María Rodríguez-López,Cristina Cotobal,Oscar Fernández-Sánchez,Natalia Borbarán Bravo,R. Oktriani,Heike Abendroth,Dardan Uka,Mimoza Hoti,Jin Wang,Mikel Zaratiegui,Jürg Bähler +10 more
TL;DR: Applying this optimized CRISPR/Cas9-based approach, this work has successfully deleted over 80 different non-coding RNA genes, which are generally lowly expressed, and have inserted 7 point mutations in 4 different genomic regions.
Journal ArticleDOI
Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast.
Tsuyoshi Udagawa,Naoki Nemoto,Caroline Wilkinson,Jana Narashimhan,Li Jiang,Stephen Watt,Aaron Zook,Nic Jones,Ronald C. Wek,Jürg Bähler,Katsura Asano +10 more
TL;DR: It is found that Int6 is required for maintaining the basal level of Atf1 and for rapid transcriptional activation of the CESR on 3AT-insult, and Pulse labeling experiments indicate that int6Δ significantly slows down de novo protein synthesis.
Journal ArticleDOI
The Role of Topoisomerase II in Meiotic Chromosome Condensation and Segregation in Schizosaccharomyces pombe
TL;DR: It is suggested that the inability to decatenate the replicated DNA is the primary defect in top2, which leads to a loss of chromatin condensation shortly before meiosis I, failure of sister chromatid separation, and a nonregulatory arrest.