J
Jürg Bähler
Researcher at University College London
Publications - 237
Citations - 24955
Jürg Bähler is an academic researcher from University College London. The author has contributed to research in topics: Schizosaccharomyces pombe & Gene. The author has an hindex of 67, co-authored 227 publications receiving 21327 citations. Previous affiliations of Jürg Bähler include University of Debrecen & European Bioinformatics Institute.
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Journal ArticleDOI
Pyruvate Kinase Variant of Fission Yeast Tunes Carbon Metabolism, Cell Regulation, Growth and Stress Resistance
Stephan Kamrad,Stephan Kamrad,Jan Grossbach,María Rodríguez-López,Michael Mülleder,Michael Mülleder,StJohn Townsend,StJohn Townsend,Valentina Cappelletti,Gorjan Stojanovski,Clara Correia-Melo,Paola Picotti,Andreas Beyer,Markus Ralser,Markus Ralser,Jürg Bähler +15 more
TL;DR: The genetic tuning of glycolytic flux may reflect an adaptive trade‐off in a species lacking pyruvate kinase isoforms, and low Pyk1 activity does not lead to a growth advantage but to stress tolerance.
Journal ArticleDOI
The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast
Elizabeth Blaikley,Helen Tinline-Purvis,Torben R. Kasparek,Samuel Marguerat,Sovan Sarkar,Lydia Hulme,Sharon P. Hussey,Boon-Yu Wee,Rachel S. Deegan,Carol Walker,Chen-Chun Pai,Jürg Bähler,Takuro Nakagawa,Timothy C. Humphrey +13 more
TL;DR: Roles for the DNA damage checkpoint pathway in facilitating homologous recombination (HR) repair and suppressing extensive LOH and chromosomal rearrangements in response to a DSB are identified and proposed.
Journal ArticleDOI
A Novel Histone Deacetylase Complex in the Control of Transcription and Genome Stability
Nicola Zilio,Sandra Codlin,Ajay A. Vashisht,Danny A. Bitton,Steven R. Head,James A. Wohlschlegel,Jürg Bähler,Michael N. Boddy +7 more
TL;DR: Collect data suggest that Clr6 I′′ has (i) indirect effects on gene expression, conceivably by mediating higher-order chromatin organization of subtelomeres and Tf2 elements, and (ii) direct effects on the transcription of specific genes in response to certain cellular or environmental stimuli.
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The fission yeast Rpb4 subunit of RNA polymerase II plays a specialized role in cell separation
TL;DR: The results suggest that Rpb4, along with some other general transcription factors, plays a specialized role in a transcriptional pathway that controls the cell cycle-regulated transcription of a specific subset of genes involved in cell division.
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Genome-wide dynamics of SAPHIRE, an essential complex for gene activation and chromatin boundaries
Matthew Gordon,Derick G. Holt,Anil K. Panigrahi,Brian T. Wilhelm,Hediye Erdjument-Bromage,Paul Tempst,Jürg Bähler,Bradley R. Cairns +7 more
TL;DR: A four-protein nucleosome-binding complex from Schizosaccharomyces pombe, termed SAPHIRE, that includes two orthologs of human Lsd1, a histone demethylase is characterized, suggesting that SAPHIre has both an important enzymatic function and an essential nonenzymatic functions.