J
Jürg Bähler
Researcher at University College London
Publications - 237
Citations - 24955
Jürg Bähler is an academic researcher from University College London. The author has contributed to research in topics: Schizosaccharomyces pombe & Gene. The author has an hindex of 67, co-authored 227 publications receiving 21327 citations. Previous affiliations of Jürg Bähler include University of Debrecen & European Bioinformatics Institute.
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Transient structural variations alter gene expression and quantitative traits in Schizosaccharomyces pombe.
Daniel C. Jeffares,Clare Jolly,Mimoza Hoti,Doug Speed,Charalampos Rallis,Liam P. Shaw,Francois Balloux,Christophe Dessimoz,Jürg Bähler,Fritz J. Sedlazeck +9 more
TL;DR: A curated catalog of copy number variants (CNVs) and rearrangements, including inversions and translocations is established, finding that SVs frequently vary within clonal populations and are weakly tagged by SNPs, consistent with rapid turnover.
Journal ArticleDOI
Metabolic heterogeneity and cross-feeding within isogenic yeast populations captured by DILAC
Stephan Kamrad,Clara Correia-Melo,Lukasz Szyrwiel,Simran Kaur Aulakh,Jürg Bähler,Vadim Demichev,Michael Mülleder,Markus Ralser +7 more
TL;DR: In this article , differential isotope labeling by amino acids (DILAC) is used to detect producer and consumer subpopulations of a particular amino acid within an isogenic cell population by monitoring peptides with multiple occurrences of the amino acid.
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Single-cell phenotyping and RNA sequencing reveal novel patterns of gene expression heterogeneity and regulation during growth and stress adaptation in a unicellular eukaryote
Malika Saint,François Bertaux,Wenhao Tang,Xi-Ming Sun,Laurence Game,Anna Köferle,Jürg Bähler,Vahid Shahrezaei,Samuel Marguerat +8 more
TL;DR: An integrated approach for imaging of individual fission yeast cells followed by single-cell RNA sequencing (scRNA-seq) and novel Bayesian normalisation is reported, revealing that the extent and dynamics of global gene-expression heterogeneity is regulated in response to different physiological conditions within populations of a unicellular eukaryote.
Journal ArticleDOI
Optimization of energy production and central carbon metabolism in a non-respiring eukaryote
TL;DR: In this paper , the authors compare two related fission yeast, Schizosaccharomyces pombe and S. japonicus, as a comparative model system, highlighting the versatility and plasticity of central carbon metabolism in eukaryotes, illuminating critical adaptations supporting the preferential use of glycolysis over oxidative phosphorylation.