K
Karl Olafsson
Researcher at University of North Carolina at Chapel Hill
Publications - 11
Citations - 1149
Karl Olafsson is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Cancer & Genome-wide association study. The author has an hindex of 8, co-authored 11 publications receiving 1040 citations.
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Journal ArticleDOI
Sequence variants at the TERT-CLPTM1L locus associate with many cancer types.
Thorunn Rafnar,Patrick Sulem,Simon N. Stacey,Frank Geller,Julius Gudmundsson,Asgeir Sigurdsson,Margret Jakobsdottir,Hafdis T. Helgadottir,Steinunn Thorlacius,Katja K H Aben,Thorarinn Blondal,Thorgeir E. Thorgeirsson,Gudmar Thorleifsson,Kristleifur Kristjansson,Kristin Thorisdottir,Rafn Ragnarsson,Bardur Sigurgeirsson,Halla Skuladottir,Tomas Gudbjartsson,Helgi J Isaksson,Gudmundur V. Einarsson,Kristrun R. Benediktsdottir,Bjarni A. Agnarsson,Karl Olafsson,Anna Salvarsdottir,Hjordis Bjarnason,Margret Asgeirsdottir,Kari T. Kristinsson,Sigurborg Matthiasdottir,Steinunn G Sveinsdottir,Silvia Polidoro,Veronica Höiom,Rafael Botella-Estrada,Kari Hemminki,Peter Rudnai,D. Timothy Bishop,Marcello Campagna,Eliane Kellen,Maurice P. Zeegers,Maurice P. Zeegers,Petra J. de Verdier,Ana Ferrer,Dolores Isla,Maria Vidal,Raquel Andrés,Berta Saez,Pablo Juberías,Javier Banzo,Sebastian Navarrete,Alejandro Tres,Donghui Kan,Annika Lindblom,Eugene Gurzau,Kvetoslava Koppova,Femmie de Vegt,Jack A. Schalken,Henricus F. M. van der Heijden,Hans J Smit,René A Termeer,Egbert Oosterwijk,Onno van Hooij,Eduardo Nagore,Stefano Porru,Gunnar Steineck,Gunnar Steineck,Johan Hansson,Frank Buntinx,Frank Buntinx,William J. Catalona,Giuseppe Matullo,Paolo Vineis,Anne E. Kiltie,Jose I. Mayordomo,Rajesh Kumar,Lambertus A. Kiemeney,Michael L. Frigge,Thorvaldur Jonsson,Hafsteinn Saemundsson,Rosa B. Barkardottir,Eirikur Jonsson,Steinn Jonsson,Jón Ólafsson,Jeffrey R. Gulcher,Gisli Masson,Daniel F. Gudbjartsson,Augustine Kong,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson +89 more
TL;DR: It is found that rs401681[C] on chromosome 5p15 satisfied the threshold for genome-wide significance and seems to confer protection against cutaneous melanoma, and investigation of the region led to rs2736098[A], which showed stronger association with some cancer types, but neither variant could fully account for the association of the other.
Journal ArticleDOI
Mutations in BRIP1 confer high risk of ovarian cancer
Thorunn Rafnar,Daniel F. Gudbjartsson,Patrick Sulem,Aslaug Jonasdottir,Asgeir Sigurdsson,Adalbjorg Jonasdottir,Søren Besenbacher,Pär Lundin,Simon N. Stacey,Julius Gudmundsson,Olafur T. Magnusson,Louise le Roux,Gudbjorg Orlygsdottir,Hafdis T. Helgadottir,Hrefna Johannsdottir,Arnaldur Gylfason,Laufey Tryggvadottir,Jon G. Jonasson,Ana de Juan,Eugenia Ortega,Jose M. Ramon-Cajal,Maria D. Garcia-Prats,Carlos Mayordomo,Angeles Panadero,Fernando Rivera,Katja K.H. Aben,Anne M. van Altena,Leon F.A.G. Massuger,Mervi Aavikko,Paula Kujala,Synnöve Staff,Lauri A. Aaltonen,Kristrun Olafsdottir,Johannes Bjornsson,Augustine Kong,Anna Salvarsdottir,Hafsteinn Saemundsson,Karl Olafsson,Kristrun R. Benediktsdottir,Jeffrey R. Gulcher,Gisli Masson,Lambertus A. Kiemeney,Jose I. Mayordomo,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson +46 more
TL;DR: Ovarian tumors from heterozygous carriers of the Icelandic mutation show loss of the wild-type allele, indicating that BRIP1 behaves like a classical tumor suppressor gene in ovarian cancer.
Journal ArticleDOI
Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.
Thorunn Rafnar,Bjarni Gunnarsson,Olafur A. Stefansson,Patrick Sulem,Andres Ingason,Michael L. Frigge,Lilja Stefansdottir,Jon K. Sigurdsson,Vinicius Tragante,Vinicius Tragante,Valgerdur Steinthorsdottir,Unnur Styrkarsdottir,Simon N. Stacey,Julius Gudmundsson,Gudny A. Arnadottir,Asmundur Oddsson,Florian Zink,Gisli H. Halldorsson,Gardar Sveinbjornsson,Ragnar P. Kristjansson,Olafur B. Davidsson,Anna Salvarsdottir,Asgeir Thoroddsen,Elisabet A. Helgadottir,Katrin Kristjansdottir,Orri Ingthorsson,Valur Gudmundsson,Reynir Tómas Geirsson,Ragnheidur Arnadottir,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Gisli Masson,Folkert W. Asselbergs,Jon G. Jonasson,Karl Olafsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Bjarni V. Halldorsson,Bjarni V. Halldorsson,Gudmar Thorleifsson,Kari Stefansson,Kari Stefansson +41 more
TL;DR: A meta-analysis of two genome-wide association studies of leiomyoma in European women uncovering 21 variants at 16 loci that associate with the disease, providing evidence of genetic overlap between leoomyoma and various benign and malignant tumors and highlighting the role of estrogen in tumor growth.
Journal ArticleDOI
BRCA2, but not BRCA1, mutations account for familial ovarian cancer in Iceland: a population-based study.
Thorunn Rafnar,Kristrun R. Benediktsdottir,Bjarki Eldon,Thorgeir Gestsson,Hafsteinn Saemundsson,Karl Olafsson,Anna Salvarsdottir,Eiríkur Steingrímsson,Steinunn Thorlacius +8 more
TL;DR: It is concluded that BRCA2 999del5 is present in 6% of ovarian cancer cases in Iceland and is associated with a 20-fold increase in the risk of the disease.
Journal ArticleDOI
Gene expression analysis of hematopoietic progenitor cells identifies Dlg7 as a potential stem cell gene.
Kristbjorn O. Gudmundsson,Leifur Thorsteinsson,Olafur E. Sigurjonsson,Jonathan R. Keller,Karl Olafsson,Torstein Egeland,Sveinn Vidar Gudmundsson,Thorunn Rafnar +7 more
TL;DR: The results suggest that Dlg7 has a role in stem cell survival, in maintaining stem cell properties, and in carcinogenesis, as well as in liver and colon carcinoma tumors.