R
Ragnar P. Kristjansson
Researcher at Amgen
Publications - 27
Citations - 1096
Ragnar P. Kristjansson is an academic researcher from Amgen. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 14, co-authored 24 publications receiving 670 citations. Previous affiliations of Ragnar P. Kristjansson include deCODE genetics.
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Journal ArticleDOI
Genetic predisposition to mosaic Y chromosome loss in blood.
Deborah J. Thompson,Giulio Genovese,Giulio Genovese,Jonatan Halvardson,Jacob C. Ulirsch,Jacob C. Ulirsch,Daniel J Wright,Daniel J Wright,Chikashi Terao,Olafur B. Davidsson,Felix R. Day,Felix R. Day,Patrick Sulem,Yunxuan Jiang,Marcus Danielsson,Hanna Davies,Joe Dennis,Malcolm G. Dunlop,Douglas F. Easton,Victoria A Fisher,Florian Zink,Richard S. Houlston,Martin Ingelsson,Siddhartha Kar,Nicola D. Kerrison,Ben Kinnersley,Ragnar P. Kristjansson,Philip J. Law,Rong Li,Chey Loveday,Jonas Mattisson,Steven A. McCarroll,Steven A. McCarroll,Yoshinori Murakami,Anna Murray,Paweł Olszewski,Edyta Rychlicka-Buniowska,Edyta Rychlicka-Buniowska,Robert A. Scott,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Ian Tomlinson,Behrooz Torabi Moghadam,Clare Turnbull,Clare Turnbull,Nicholas J. Wareham,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Yoichiro Kamatani,Eva Hoffmann,Steve P Jackson,Steve P Jackson,Kari Stefansson,Adam Auton,Ken K. Ong,Mitchell J. Machiela,Mitchell J. Machiela,Po-Ru Loh,Po-Ru Loh,Jan P. Dumanski,Stephen J. Chanock,Stephen J. Chanock,Lars Forsberg,Lars Forsberg,John R. B. Perry,John R. B. Perry +65 more
TL;DR: A genome-wide association study of mosaic loss of chromosome Y in UK Biobank participants identifies 156 genetic determinants of LOY, showing that LOY is associated with cancer and non-haematological health outcomes and supports the hypothesis that clonal haematopoiesis is a biomarker of genomic instability in other tissues.
Journal ArticleDOI
Long-read sequencing of 3,622 Icelanders provides insight into the role of structural variants in human diseases and other traits.
Doruk Beyter,Helga Ingimundardottir,Asmundur Oddsson,Hannes P. Eggertsson,Hannes P. Eggertsson,Eythor Bjornsson,Eythor Bjornsson,Hakon Jonsson,Bjarni A Atlason,Snaedis Kristmundsdottir,Snaedis Kristmundsdottir,Svenja Mehringer,Marteinn T. Hardarson,Sigurjon A. Gudjonsson,Droplaug N Magnusdottir,Aslaug Jonasdottir,Adalbjorg Jonasdottir,Ragnar P. Kristjansson,Sverrir T. Sverrisson,Guillaume Holley,Gunnar K. Pálsson,Olafur A. Stefansson,Gudmundur I. Eyjolfsson,Isleifur Olafsson,Olof Sigurdardottir,Bjarni Torfason,Gisli Masson,Agnar Helgason,Agnar Helgason,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Hilma Holm,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Patrick Sulem,Olafur T. Magnusson,Bjarni V. Halldorsson,Bjarni V. Halldorsson,Kari Stefansson,Kari Stefansson +39 more
TL;DR: In this article, a set of 133,886 reliably genotyped structural variants (SVs) were imputed into 166,281 individuals to explore their effects on diseases and other traits.
Journal ArticleDOI
A homozygous loss-of-function mutation leading to CYBC1 deficiency causes chronic granulomatous disease
Gudny A. Arnadottir,Gudmundur L. Norddahl,Steinunn Gudmundsdottir,Arna B Agustsdottir,Snaevar Sigurdsson,Brynjar O. Jensson,Kristbjorg Bjarnadottir,Fannar Theodors,Stefania Benonisdottir,Erna V. Ivarsdottir,Erna V. Ivarsdottir,Asmundur Oddsson,Ragnar P. Kristjansson,Gerald Sulem,Kristjan F. Alexandersson,Thorhildur Juliusdottir,Kjartan R Gudmundsson,Jona Saemundsdottir,Adalbjorg Jonasdottir,Aslaug Jonasdottir,Asgeir Sigurdsson,Paolo Manzanillo,Sigurjon A. Gudjonsson,Gudmundur A. Thorisson,Olafur Th Magnusson,Gisli Masson,Kjartan B. Orvar,Hilma Holm,Sigurdur Bjornsson,Reynir Arngrímsson,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Ingileif Jonsdottir,Ingileif Jonsdottir,Ásgeir Haraldsson,Ásgeir Haraldsson,Patrick Sulem,Kari Stefansson,Kari Stefansson +40 more
TL;DR: It is found that CYBC1 deficiency results in CGD characterized by colitis and a distinct profile of infections indicative of macrophage dysfunction, and is important for formation of the NADPH complex and respiratory burst.
Journal ArticleDOI
Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility
Hamdi Mbarek,Stacy Steinberg,Dale R. Nyholt,Dale R. Nyholt,Scott D. Gordon,Michael B. Miller,Allan F. McRae,Allan F. McRae,Jouke-Jan Hottenga,Felix R. Day,Gonneke Willemsen,Eco J. C. de Geus,Gareth E. Davies,Hilary C. Martin,Brenda W.J.H. Penninx,Rick Jansen,Kerrie McAloney,Jacqueline M. Vink,Jaakko Kaprio,Robert Plomin,Tim D. Spector,Patrik K. E. Magnusson,Bruno Reversade,Bruno Reversade,R. Alan Harris,Kjersti Aagaard,Ragnar P. Kristjansson,Isleifur Olafsson,Gudmundur I. Eyjolfsson,Olof Sigurdardottir,William G. Iacono,Cornelis B. Lambalk,Grant W. Montgomery,Matt McGue,Ken K. Ong,John Perry,Nicholas G. Martin,Hreinn Stefánsson,Kari Stefansson,Dorret I. Boomsma +39 more
TL;DR: In this paper, the authors performed a GWAS in 1,980 mothers of spontaneous Dizygotic (DZ) twins and 12,953 control subjects and identified robust genetic risk variants for DZ twinning: one near FSHB and a second within SMAD3.
Journal ArticleDOI
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis
Ragnar P. Kristjansson,Stefania Benonisdottir,Olafur B. Davidsson,Asmundur Oddsson,Vinicius Tragante,Vinicius Tragante,Jon K. Sigurdsson,Lilja Stefansdottir,Stefan Jonsson,Brynjar O. Jensson,Joseph G. Arthur,Gudny A. Arnadottir,Gerald Sulem,Bjarni V. Halldorsson,Bjarni V. Halldorsson,Bjarni Gunnarsson,Gisli H. Halldorsson,Olafur A. Stefansson,Gudjon R. Oskarsson,Aimee M. Deaton,Isleifur Olafsson,Gudmundur I. Eyjolfsson,Olof Sigurdardottir,Pall T. Onundarson,David Gislason,David Gislason,Thorarinn Gislason,Bjorn R. Ludviksson,Bjorn R. Ludviksson,Dora Ludviksdottir,Thorunn A. Olafsdottir,Thorunn A. Olafsdottir,Thorunn Rafnar,Gisli Masson,Florian Zink,Gyda Bjornsdottir,Olafur Th Magnusson,Unnur S. Bjornsdottir,Gudmar Thorleifsson,Gudmundur L. Norddahl,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Ingileif Jonsdottir,Ingileif Jonsdottir,Patrick Sulem,Kari Stefansson,Kari Stefansson +48 more
TL;DR: Genome-wide-association analyses of datasets from Iceland and the UK identify risk variants for nasal polyps and chronic rhinosinusitis and a loss-of-function missense variant in ALOX15 confers protection against both phenotypes, thus identifying a potential target for therapeutic intervention.