J
Jon K. Sigurdsson
Researcher at deCODE genetics
Publications - 8
Citations - 338
Jon K. Sigurdsson is an academic researcher from deCODE genetics. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 6, co-authored 8 publications receiving 191 citations.
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Journal ArticleDOI
A genome-wide association study yields five novel thyroid cancer risk loci.
Julius Gudmundsson,Gudmar Thorleifsson,Jon K. Sigurdsson,Lilja Stefansdottir,Jon G. Jonasson,Sigurjon A. Gudjonsson,Daniel F. Gudbjartsson,Gisli Masson,Hrefna Johannsdottir,Gisli H. Halldorsson,Simon N. Stacey,Hannes Helgason,Hannes Helgason,Patrick Sulem,Leigha Senter,Huiling He,Sandya Liyanarachchi,Matthew D. Ringel,Esperanza Aguillo,Angeles Panadero,Enrique Prats,Almudena García-Castaño,Ana de Juan,Fernando Rivera,Li Xu,Lambertus A. Kiemeney,Gudmundur I. Eyjolfsson,Olof Sigurdardottir,Isleifur Olafsson,Hoskuldur Kristvinsson,Romana T. Netea-Maier,Thorvaldur Jonsson,Jose I. Mayordomo,Theo S. Plantinga,Hannes Hjartarson,Jon Hrafnkelsson,Erich M. Sturgis,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Thorunn Rafnar,Albert de la Chapelle,Kari Stefansson,Kari Stefansson +42 more
TL;DR: Findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent, raise several opportunities for future studies of the pathogenesis of thyroid cancer.
Journal ArticleDOI
FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease.
Saedis Saevarsdottir,Thorunn A. Olafsdottir,Thorunn A. Olafsdottir,Erna V. Ivarsdottir,Erna V. Ivarsdottir,Gisli H. Halldorsson,Kristbjorg Gunnarsdottir,Asgeir Sigurdsson,Ari Johannesson,Jon K. Sigurdsson,Thorhildur Juliusdottir,Sigrun H. Lund,Asgeir O. Arnthorsson,Edda L. Styrmisdottir,Julius Gudmundsson,Gerdur M. Grondal,Gerdur M. Grondal,Kristjan Steinsson,Lars Alfredsson,Johan Askling,Rafn Benediktsson,Rafn Benediktsson,Ragnar Bjarnason,Ragnar Bjarnason,Arni Jon Geirsson,Arni Jon Geirsson,Bjorn Gudbjornsson,Hallgrimur Gudjonsson,Hallgrimur Gudjonsson,Haukur Hjaltason,Haukur Hjaltason,Astradur B. Hreidarsson,Astradur B. Hreidarsson,Lars Klareskog,Ingrid Kockum,Helga Kristjansdottir,Thorvardur Jon Love,Bjorn R. Ludviksson,Bjorn R. Ludviksson,Tomas Olsson,Pall T. Onundarson,Kjartan B. Orvar,Kjartan B. Orvar,Leonid Padyukov,Bardur Sigurgeirsson,Vinicius Tragante,Kristbjorg Bjarnadottir,Thorunn Rafnar,Gisli Masson,Patrick Sulem,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Páll Melsted,Páll Melsted,Gudmar Thorleifsson,Gudmundur L. Norddahl,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,I. Jonsdottir,I. Jonsdottir,I. Jonsdottir,Kari Stefansson,Kari Stefansson +62 more
TL;DR: A predicted loss-of-function germline mutation in FLT3 causes a reduction in full-lengthFLT3, with a compensatory increase in the levels of its ligand and an increased disease risk, similar to that of a gain- of-function mutation.
Journal ArticleDOI
Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.
Thorunn Rafnar,Bjarni Gunnarsson,Olafur A. Stefansson,Patrick Sulem,Andres Ingason,Michael L. Frigge,Lilja Stefansdottir,Jon K. Sigurdsson,Vinicius Tragante,Vinicius Tragante,Valgerdur Steinthorsdottir,Unnur Styrkarsdottir,Simon N. Stacey,Julius Gudmundsson,Gudny A. Arnadottir,Asmundur Oddsson,Florian Zink,Gisli H. Halldorsson,Gardar Sveinbjornsson,Ragnar P. Kristjansson,Olafur B. Davidsson,Anna Salvarsdottir,Asgeir Thoroddsen,Elisabet A. Helgadottir,Katrin Kristjansdottir,Orri Ingthorsson,Valur Gudmundsson,Reynir Tómas Geirsson,Ragnheidur Arnadottir,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Gisli Masson,Folkert W. Asselbergs,Jon G. Jonasson,Karl Olafsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Bjarni V. Halldorsson,Bjarni V. Halldorsson,Gudmar Thorleifsson,Kari Stefansson,Kari Stefansson +41 more
TL;DR: A meta-analysis of two genome-wide association studies of leiomyoma in European women uncovering 21 variants at 16 loci that associate with the disease, providing evidence of genetic overlap between leoomyoma and various benign and malignant tumors and highlighting the role of estrogen in tumor growth.
Journal ArticleDOI
Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA.
Julius Gudmundsson,Jon K. Sigurdsson,Lilja Stefansdottir,Bjarni A. Agnarsson,Helgi J Isaksson,Olafur A. Stefansson,Sigurjon A. Gudjonsson,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Gisli Masson,Michael L. Frigge,Simon N. Stacey,Patrick Sulem,Gisli H. Halldorsson,Vinicius Tragante,Vinicius Tragante,Hilma Holm,Gudmundur I. Eyjolfsson,Olof Sigurdardottir,Isleifur Olafsson,Thorvaldur Jonsson,Eirikur Jonsson,Rosa B. Barkardottir,Rafn Hilmarsson,Folkert W. Asselbergs,Gudmundur Geirsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Thorunn Rafnar,Gudmar Thorleifsson,Kari Stefansson,Kari Stefansson +31 more
TL;DR: A genome-wide association study of symptomatic BPH/LUTS patients from Iceland and the UK found 23 significant variants at 14 loci, and 15 of these variants associate with prostate specific antigen, which is linked to prostate cancer risk.
Journal ArticleDOI
Association of BRCA2 K3326* With Small Cell Lung Cancer and Squamous Cell Cancer of the Skin
Thorunn Rafnar,Gudbjorg R Sigurjonsdottir,Simon N. Stacey,Gisli H. Halldorsson,Patrick Sulem,Luba M. Pardo,Hannes Helgason,Hannes Helgason,Stefan T Sigurdsson,Thorkell Gudjonsson,Laufey Tryggvadottir,Gudridur H Olafsdottir,Jon G. Jonasson,Kristin Alexiusdottir,Asgeir Sigurdsson,Julius Gudmundsson,Jona Saemundsdottir,Jon K. Sigurdsson,Hrefna Johannsdottir,André G. Uitterlinden,Sita H. Vermeulen,Tessel E. Galesloot,Dawn C. Allain,Martin Lacko,Bardur Sigurgeirsson,Kristin Thorisdottir,Oskar T. Johannsson,Fridbjorn Sigurdsson,Gunnar B Ragnarsson,Helgi J Isaksson,Hronn Hardardottir,Tomas Gudbjartsson,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Gisli Masson,L.A. Kiemeney,Amanda E. Toland,Tamar Nijsten,Wilbert H.M. Peters,Jón Ólafsson,Steinn Jonsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Gudmar Thorleifsson,Kari Stefansson,Kari Stefansson +45 more
TL;DR: In this article, the authors reported an association between K3326* and small cell lung cancer (odds ratio [OR] = 2.06, 95% confidence interval [CI] = 1.35 to 3.16) and squamous cell carcinoma of the skin (OR = 1., 95% CI: 1.26 to 2.26).