T
Taras Kreslavsky
Researcher at Karolinska University Hospital
Publications - 32
Citations - 2370
Taras Kreslavsky is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: T cell & T-cell receptor. The author has an hindex of 20, co-authored 29 publications receiving 1858 citations. Previous affiliations of Taras Kreslavsky include Harvard University & Research Institute of Molecular Pathology.
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Journal ArticleDOI
Stable inhibitory activity of regulatory T cells requires the transcription factor Helios
Hye-Jung Kim,R. Anthony Barnitz,R. Anthony Barnitz,Taras Kreslavsky,Flavian D. Brown,Howell F. Moffett,Madeleine E. Lemieux,Yasemin Kaygusuz,Torsten B. Meissner,Tobias A. W. Holderried,Susan Chan,Philippe Kastner,W. Nicholas Haining,W. Nicholas Haining,W. Nicholas Haining,Harvey Cantor +15 more
TL;DR: It is reported that impaired expression of the transcription factor Helios by FoxP3+ CD4 and Qa-1–restricted CD8 Tregs results in defective regulatory activity and autoimmunity in mice.
Journal ArticleDOI
TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity
Taras Kreslavsky,Adam K. Savage,Robin M. Hobbs,Fotini Gounari,Roderick T. Bronson,Pablo Pereira,Pier Paolo Pandolfi,Albert Bendelac,Harald von Boehmer +8 more
TL;DR: Transgenic expression of Vγ1Vδ6.4 TCR was sufficient to support the development of large numbers of PLZF+ T cells, further supporting the importance of the TCR forPLZF induction.
Journal ArticleDOI
The transcriptional landscape of αβ T cell differentiation
Michael Mingueneau,Taras Kreslavsky,Daniel H.D. Gray,Daniel H.D. Gray,Tracy Heng,Richard M. Cruse,Jeffrey Ericson,Sean C. Bendall,Matthew H. Spitzer,Garry P. Nolan,Koichi Kobayashi,Koichi Kobayashi,Harald von Boehmer,Diane Mathis,Christophe Benoist +14 more
TL;DR: It is found that early T cell commitment was driven by unexpectedly gradual changes, and transcripts newly identified as encoding candidate mediators of key transitions help define the 'known unknowns' of thymocyte differentiation.
Identification of transcriptional regulators in the mouse immune system
Vladimir Jojic,Tal Shay,Katelyn Sylvia,Or Zuk,Xin Sun,Joonsoo Kang,Aviv Regev,Daphne Koller,Adam J Best,Jamie Knell,Ananda W. Goldrath,Nadia Cohen,Patrick J. Brennan,Michael B. Brenner,Francis Kim,Tata Nageswara Rao,Amy J. Wagers,Tracy Heng,Jeffrey Ericson,Katherine Rothamel,Adriana Ortiz-Lopez,Diane Mathis,Christophe Benoist,Natalie A. Bezman,Joseph C. Sun,Gundula Min-Oo,Charles C. Kim,Lewis L. Lanier,Jennifer Miller,Brian D. Brown,Miriam Merad,Emmanuel L. Gautier,Claudia Jakubzick,Gwendalyn J. Randolph,Paul A. Monach,David A. Blair,Michael L. Dustin,Susan A. Shinton,Richard R. Hardy,David H. Laidlaw,James J. Collins,Roi Gazit,Derrick J. Rossi,Nidhi Malhotra,Taras Kreslavsky,Anne L. Fletcher,Kutlu G. Elpek,Angelique Bellemare-Pelletier,Deepali Malhotra,Shannon J. Turley +49 more
TL;DR: The Immunological Genome Project gene-expression profiles across mouse immune lineages allowed us to systematically analyze transcriptional circuitry that controls the differentiation of hematopoietic stem cells into cells of the immune system, and Ontogenet, an algorithm for reconstructing lineage-specific regulation from gene- expression profiles across lineages, was developed.
Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes
Kavitha Narayan,Katelyn E Sylvia,Nidhi Malhotra,Catherine C. Yin,Gregory W. Martens,Therese Vallerskog,Hardy Kornfeld,Na Xiong,Nadia R Cohen,Michael B. Brenner,Leslie J. Berg,Joonsoo Kang,Yan Zhou,Susan A. Shinton,Richard R. Hardy,Natalie A. Bezman,Joseph C. Sun,Charles C. Kim,Lewis L. Lanier,Jennifer Miller,Brian D. Brown,Miriam Merad,Anne L. Fletcher,Kutlu G. Elpek,Angelique Bellemare-Pelletier,Deepali Malhotra,Shannon J. Turley,Katelyn Sylvia,Roi Gazit,Brian S. Garrison,Derrick J. Rossi,Vladimir Jojic,Daphne Koller,Radu Jianu,David H. Laidlaw,James C. Costello,James J. Collins,Nadia Cohen,Patrick J. Brennan,Michael Brenner,Tal Shay,Aviv Regev,Francis Kim,Tata Nageswara Rao,Amy J. Wagers,Emmanuel L. Gautier,Claudia Jakubzick,Gwendalyn J. Randolph,Paul A. Monach,Adam J Best,Jamie Knell,Ananda W. Goldrath,Tracy Heng,Taras Kreslavsky,Michio W. Painter,Diane Mathis,Christophe Benoist +56 more