S
Simone Lipinski
Researcher at University of Kiel
Publications - 35
Citations - 2915
Simone Lipinski is an academic researcher from University of Kiel. The author has contributed to research in topics: NOD2 & Colitis. The author has an hindex of 21, co-authored 34 publications receiving 2353 citations.
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Journal ArticleDOI
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
Tatsuo Hashimoto,Thomas Perlot,Ateequr Rehman,Ateequr Rehman,Jean Trichereau,Hiroaki Ishiguro,Magdalena Paolino,Verena Sigl,Toshikatsu Hanada,Reiko Hanada,Simone Lipinski,Birgit Wild,Simone M. R. Camargo,Dustin Singer,Andreas Richter,Keiji Kuba,Akiyoshi Fukamizu,Stefan Schreiber,Hans Clevers,François Verrey,Philip Rosenstiel,Josef M. Penninger +21 more
TL;DR: The results identify ACE2 as a key regulator of dietary amino acid homeostasis, innate immunity, gut microbial ecology, and transmissible susceptibility to colitis, providing a molecular explanation for how amino acid malnutrition can cause intestinal inflammation and diarrhoea.
Journal ArticleDOI
Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing
Julia Richter,Matthias Schlesner,Steve Hoffmann,Markus Kreuz,Ellen Leich,Birgit Burkhardt,Maciej Rosolowski,Ole Ammerpohl,Rabea Wagener,Stephan H. Bernhart,Dido Lenze,Monika Szczepanowski,Maren Paulsen,Simone Lipinski,Robert B. Russell,Sabine Adam-Klages,Gordana Apic,Alexander Claviez,Dirk Hasenclever,Volker Hovestadt,Nadine Hornig,Jan O. Korbel,Dieter Kube,David Langenberger,Chris Lawerenz,Jasmin Lisfeld,Katharina Meyer,Simone Picelli,Jordan Pischimarov,Bernhard Radlwimmer,Tobias Rausch,Marius Rohde,Markus Schilhabel,René Scholtysik,Rainer Spang,Heiko Trautmann,Thorsten Zenz,Thorsten Zenz,Thorsten Zenz,Arndt Borkhardt,Hans G. Drexler,Peter Möller,Roderick A.F. MacLeod,Christiane Pott,Stefan Schreiber,Lorenz Trümper,Markus Loeffler,Peter F. Stadler,Peter Lichter,Roland Eils,Ralf Küppers,Michael Hummel,Wolfram Klapper,Philip Rosenstiel,Andreas Rosenwald,Benedikt Brors,Reiner Siebert +56 more
TL;DR: Findings suggest that cooperation between ID3 inactivation and IG-MYC translocation is a hallmark of Burkitt lymphomagenesis.
Journal ArticleDOI
DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses
Simone Lipinski,Andreas Till,Christian Sina,Alexander Arlt,Helmut Grasberger,Stefan Schreiber,Philip Rosenstiel +6 more
TL;DR: In this paper, the authors demonstrate controlled reactive oxygen species (ROS) generation as an integral component of NOD2-induced signalling in epithelial cells and demonstrate that the NAD(P)H oxidase family member DUOX2 is involved in NOD-dependent ROS production.
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The Nucleotide-Binding Oligomerization Domain-Like Receptor NLRC5 Is Involved in IFN-Dependent Antiviral Immune Responses
Sven Kuenzel,Andreas Till,Michael Winkler,Robert Häsler,Simone Lipinski,Sascha Jung,Joachim Grötzinger,Helmut Fickenscher,Stefan Schreiber,Philip Rosenstiel +9 more
TL;DR: It is concluded that NLRC5 may represent a molecular switch of IFN-γ activation sequence/IFN-specific response element signaling pathways contributing to antiviral defense mechanisms.
Journal ArticleDOI
Association Between Variants of PRDM1 and NDP52 and Crohn's Disease, Based on Exome Sequencing and Functional Studies
David Ellinghaus,Hu Zhang,Hu Zhang,Sebastian Zeissig,Simone Lipinski,Andreas Till,Tao Jiang,Björn Stade,Yana Bromberg,Eva Ellinghaus,Andreas Keller,Manuel A. Rivas,Manuel A. Rivas,Manuel A. Rivas,Jurgita Skieceviciene,Nadezhda Tsankova Doncheva,Xiao Liu,Qing Liu,Fuman Jiang,Michael Forster,Gabriele Mayr,Mario Albrecht,Mario Albrecht,Robert Häsler,Bernhard O. Boehm,Jane C. Goodall,Carlo Berzuini,James Lee,Vibeke Andersen,Ulla Vogel,Limas Kupčinskas,Manfred Kayser,Michael Krawczak,Susanna Nikolaus,Rinse K. Weersma,Cyriel Y. Ponsioen,Miquel Sans,Cisca Wijmenga,David P. Strachan,Wendy L. McArdle,Severine Vermeire,Paul Rutgeerts,Jeremy D. Sanderson,Christopher G. Mathew,Morten H. Vatn,Jun Wang,Markus M. Nöthen,Richard H. Duerr,Carsten Büning,Stephan Brand,Jürgen Glas,Jürgen Glas,Juliane Winkelmann,Thomas Illig,Anna Latiano,Vito Annese,Jonas Halfvarson,Mauro D'Amato,Mark J. Daly,Mark J. Daly,Michael Nothnagel,Tom H. Karlsen,Tom H. Karlsen,Suresh Subramani,Philip Rosenstiel,Stefan Schreiber,Miles Parkes,Andre Franke +67 more
TL;DR: Evidence is provided that variants in PRDM1 and NDP52 determine susceptibility to CD, and this variant impairs the regulatory functions of NDP52 to inhibit nuclear factor κB activation of genes that regulate inflammation and affect the stability of proteins in Toll-like receptor pathways.