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Keith D Harshman
Researcher at Myriad Genetics
Publications - 22
Citations - 10536
Keith D Harshman is an academic researcher from Myriad Genetics. The author has contributed to research in topics: Breast cancer & Gene mutation. The author has an hindex of 10, co-authored 18 publications receiving 10237 citations. Previous affiliations of Keith D Harshman include University of Utah.
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Journal ArticleDOI
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
Yoshio Miki,Jeff Swensen,Donna M Shattuck-Eidens,P. Andrew Futreal,Keith D Harshman,Sean V. Tavtigian,Qingyun Liu,Charles Cochran,L. Michelle Bennett,Wei Ding,Russell Bell,Judith Rosenthal,Charles E. Hussey,Thanh Tran,Melody McClure,Cheryl Frye,Tom Hattier,Robert Phelps,Astrid Haugen-Strano,Harold Katcher,Kazuko Yakumo,Zahra Gholami,Daniel Shaffer,Steven Stone,Steven Bayer,Christian Wray,Robert Bogden,Priya Dayananth,John R. Ward,Patricia N. Tonin,Steven A. Narod,Pam K. Bristow,Frank H. Norris,Leah M. Helvering,Paul Morrison,Paul Robert Rosteck,Mei Lai,J. Carl Barrett,Cathryn M. Lewis,Susan L. Neuhausen,Lisa A. Cannon-Albright,David E. Goldgar,Roger W. Wiseman,Alexander Kamb,Mark H. Skolnick +44 more
TL;DR: A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods.
Journal ArticleDOI
A cell cycle regulator potentially involved in genesis of many tumor types
Alexander Kamb,Nelleke A. Gruis,Jane Weaver-Feldhaus,Qingyun Liu,Keith D Harshman,Sean V. Tavtigian,Elisabeth Stockert,Rufus S. Day,Bruce E. Johnson,Mark H. Skolnick,Mark H. Skolnick +10 more
TL;DR: Findings suggest that MTS1 mutations are involved in tumor formation in a wide range of tissues.
Journal ArticleDOI
BRCA1 mutations in primary breast and ovarian carcinomas
P. Andrew Futreal,Qingyun Liu,Donna M Shattuck-Eidens,Charles Cochran,Keith D Harshman,Sean V. Tavtigian,L. Michelle Bennett,Astrid Haugen-Strano,Jeff Swensen,Yoshio Miki,Ken Eddington,Melody McClure,Cheryl Frye,Jane Weaver-Feldhaus,Wei Ding,Zahra Gholami,Peter Söderkvist,Lori A. Terry,Suresh C. Jhanwar,Andrew Berchuck,J. Dirk Iglehart,Jeffrey R. Marks,Dennis G. Ballinger,J. Cari Barrett,Mark H. Skolnick,Mark H. Skolnick,Alexander Kamb,Roger W. Wiseman +27 more
TL;DR: Results suggest that mutation of BRCA1 may not be critical in the development of the majority of breast and ovarian cancers that arise in the absence of a mutant germline allele.
Patent
17q-Linked breast and ovarian cancer susceptibility gene
Mark H. Skolnick,David E. Goldgar,Yoshio Miki,Jeff Swenson,Alexander Kamb,Keith D Harshman,Donna M Shattuck-Eidens,Sean V. Tavtigian,Roger W. Wiseman,P. Andrew Futreal +9 more
TL;DR: In this paper, the authors proposed methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, and their use in the diagnosis and prognosis of human cancers.
Journal ArticleDOI
Evidence of linkage of familial hypoalphalipoproteinemia to a novel locus on chromosome 11q23.
E. N. Kort,Dennis G. Ballinger,Wei Ding,Steven C. Hunt,Benjamin R. Bowen,Victor Abkevich,K Bulka,B. Campbell,C. Capener,Alexander Gutin,Keith D Harshman,M. McDermott,T. Thorne,Hui-Chun Wang,Bryan Wardell,Jathine Wong,Paul N. Hopkins,Mark H. Skolnick,Mark E. Samuels +18 more
TL;DR: This study assesses the evidence for linkage of low HDL-C to chromosomal region 11q23 in 105 large Utah pedigrees ascertained with closely related clusters of early CHD and expanded on the basis of dyslipidemia.