K
Kohei Kaku
Researcher at Kawasaki Medical School
Publications - 347
Citations - 7993
Kohei Kaku is an academic researcher from Kawasaki Medical School. The author has contributed to research in topics: Diabetes mellitus & Type 2 diabetes. The author has an hindex of 44, co-authored 311 publications receiving 6921 citations. Previous affiliations of Kohei Kaku include Kawasaki University of Medical Welfare.
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Journal ArticleDOI
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations
Hiroyuki Unoki,Atsushi Takahashi,Takahisa Kawaguchi,Kazuo Hara,Momoko Horikoshi,Gitte Andersen,Daniel P.K. Ng,Johan Holmkvist,Knut Borch-Johnsen,Knut Borch-Johnsen,Knut Borch-Johnsen,Torben Jørgensen,Annelli Sandbæk,Torsten Lauritzen,Torben Hansen,Siti Nurbaya,Tatsuhiko Tsunoda,Michiaki Kubo,Tetsuya Babazono,Hiroshi Hirose,Matsuhiko Hayashi,Yasuhiko Iwamoto,Atsunori Kashiwagi,Kohei Kaku,Ryuzo Kawamori,E. Shyong Tai,Oluf Pedersen,Oluf Pedersen,Naoyuki Kamatani,Takashi Kadowaki,Ryuichi Kikkawa,Yusuke Nakamura,Shiro Maeda +32 more
TL;DR: A genome-wide association study using 207,097 SNP markers in Japanese individuals with type 2 diabetes and unrelated controls identified KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) to be a strong candidate for conferring susceptibility to type 1 diabetes.
Journal ArticleDOI
Voglibose for prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese individuals with impaired glucose tolerance
Ryuzo Kawamori,Naoko Tajima,Yasuhiko Iwamoto,Atsunori Kashiwagi,Kazuaki Shimamoto,Kohei Kaku +5 more
TL;DR: Voglibose, in addition to lifestyle modification, can reduce the development of type 2 diabetes in high-risk Japanese individuals with impaired glucose tolerance.
Journal ArticleDOI
Genetic variations in the gene encoding ELMO1 are associated with susceptibility to diabetic nephropathy.
Atsuyuki Shimazaki,Yoshihiro Kawamura,Akio Kanazawa,Akihiro Sekine,Susumu Saito,Tatsuhiko Tsunoda,Daisuke Koya,Tetsuya Babazono,Yasushi Tanaka,Masafumi Matsuda,Koichi Kawai,Tomohiro Iiizumi,Masahito Imanishi,Toshihiro Shinosaki,Toru Yanagimoto,Minoru Ikeda,Shigeki Omachi,Atsunori Kashiwagi,Kohei Kaku,Yasuhiko Iwamoto,R. Kawamori,Ryuichi Kikkawa,Masatoshi Nakajima,Yusuke Nakamura,Shiro Maeda +24 more
TL;DR: Results indicate that ELMO1 is a novel candidate gene that both confers susceptibility to DN and plays an important role in the development and progression of this disease.
Journal ArticleDOI
Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial
Kohjiro Ueki,Takayoshi Sasako,Yukiko Okazaki,Masayuki Kato,Sumie Okahata,Hisayuki Katsuyama,Mikiko Haraguchi,Ai Morita,Ken Ohashi,Kazuo Hara,Atsushi Morise,Kazuo Izumi,Naoki Ishizuka,Yasuo Ohashi,Mitsuhiko Noda,Takashi Kadowaki,Masakazu Haneda,Yasunori Iwashima,Toshihiro Suda,Naoki Tamasawa,Makoto Daimon,Jo Satoh,Noriko Takebe,Yasushi Ishigaki,Tsuyoshi Watanabe,Hiroaki Satoh,Kikuo Kasai,Yoshimasa Aso,Shun Ishibashi,Shigehiro Katayama,San e. Ishikawa,Masafumi Kakei,Kazuyuki Namai,Naotake Hashimoto,Yoshifumi Suzuki,Shunichiro Onishi,Koutaro Yokote,Masafumi Matsuda,Masahiro Masuzawa,Yoichi Hayashi,Satoshi Saito,Norikazu Ogihara,Hisamitsu Ishihara,Naoko Tajima,Kazunori Utsunomiya,Akira Shimada,Hiroshi Itoh,Ryuzo Kawamori,Hirotaka Watada,Michio Hayashi,Yasumichi Mori,Teruo Shiba,Akihiro Isogawa,Hiroshi Sakura,Masato Odawara,Kazuyuki Tobe,Kazuhisa Tsukamoto,Toshimasa Yamauchi,Tamio Teramoto,Yukio Hirata,Isao Uchimura,Yoshihiro Ogawa,Gen Yoshino,Takahisa Hirose,Hiroshi Kajio,Yoshihito Atsumi,Yoichi Oikawa,Atsushi Araki,Akio Ueki,Atsushi Ohno,Masafumi Kitaoka,Yoshikuni Fujita,Tatsumi Moriya,Taiki Tojo,Masayoshi Shichiri,Daisuke Suzuki,Masao Toyoda,Kumiko Hamano,Rieko Komi,Yasuo Terauchi,Nobuaki Kuzuya,Masayo Yamada,Toshinari Takamura,Mitsuo Imura,Hiroshi Tanaka,Masayuki Hayashi,Yasuhisa Kato,Mitsuyasu Itoh,Atsushi Suzuki,Mikihiro Nakayama,Takahisa Sano,Eitaro Nakashima,Yasuhiro Sumida,Yutaka Yano,Tsuyoshi Tanaka,Kazuya Murata,Atsunori Kashiwagi,Hiroshi Maegawa,Shigeo Kono,Nobuya Inagaki,Keisuke Kosugi,Tetsuyuki Yasuda,Yasunao Yoshimasa,Ichiro Kishimoto,Toshihiko Sato,Masayuki Hosoi,Tomoyuki Yamasaki,Munehide Matsuhisa,Iichiro Shimomura,Ataru Taniguchi,Akira Kuroe,Takeshi Kurose,Takeshi Ohara,Kazuhiko Sakaguchi,Mitsuyoshi Namba,Kohei Kaku,Masazumi Fujiwara,Ikki Shimizu,Keizo Ono,Osamu Ebisui,Yukio Tanizawa,Yosuke Okada,Shoichi Natori,Takehiko Kodera,Naoichi Sato,Makoto Ide,Kentaro Yamada,Fumio Umeda,Tomoaki Eto,Kazuo Mimura,Shinsuke Hiramatsu,Tomoaki Inoue,Ryoko Takei,Atsushi Ogo,Katsumi Eguchi,Eiji Kawasaki,Yuji Koide,Eiichi Araki,Hideaki Jinnouchi,Hiroaki Yamamoto,Mitsutaka Motoyoshi,Toru Hiyoshi,Yasushi Tanaka,Tadahisa Momoki,Koichiro Sato,Akihiko Yoneyama,Kenichi Ito,Hiroshi Sobajima,Hiroshi Ikegami,Masaki Ikeda,Hiroki Ikeda,Kenji Takahashi,Hirofumi Makino,Yasuo Ueda,Masamitsu Nakazato +154 more
TL;DR: This multicentre, open-label, randomised, parallel-group trial, undertaken at 81 clinical sites in Japan, randomly assigned patients with type 2 diabetes with hypertension, dyslipidaemia, or both to receive conventional therapy or intensive therapy for glucose, blood pressure, and lipid control.
Journal ArticleDOI
Association of the Gene Encoding Wingless-Type Mammary Tumor Virus Integration-Site Family Member 5B (WNT5B) with Type 2 Diabetes
Akio Kanazawa,Syuuichi Tsukada,Akihiro Sekine,Tatsuhiko Tsunoda,Atsushi Takahashi,Atsunori Kashiwagi,Yasushi Tanaka,Tetsuya Babazono,Masafumi Matsuda,Kohei Kaku,Yasuhiko Iwamoto,Ryuzo Kawamori,Ryuichi Kikkawa,Yusuke Nakamura,Shiro Maeda +14 more
TL;DR: The results indicate that the WNT5B gene may contribute to conferring susceptibility to type 2 diabetes and may be involved in the pathogenesis of this disease through the regulation of adipocyte function.