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Shiro Maeda

Researcher at University of the Ryukyus

Publications -  190
Citations -  11344

Shiro Maeda is an academic researcher from University of the Ryukyus. The author has contributed to research in topics: Single-nucleotide polymorphism & Genome-wide association study. The author has an hindex of 51, co-authored 182 publications receiving 10023 citations. Previous affiliations of Shiro Maeda include National Taiwan University & University of Mississippi Medical Center.

Papers
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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

Anubha Mahajan, +395 more
- 01 Mar 2014 - 
TL;DR: In this paper, the authors aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry.
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SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

Hiroyuki Unoki, +32 more
- 01 Sep 2008 - 
TL;DR: A genome-wide association study using 207,097 SNP markers in Japanese individuals with type 2 diabetes and unrelated controls identified KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) to be a strong candidate for conferring susceptibility to type 1 diabetes.
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Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

Yoon Shin Cho, +72 more
- 01 Jan 2012 - 
TL;DR: The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3, which may regulate glucose-dependent insulin secretion in the pancreas.
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Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes

Daisuke Koya, +11 more
- 01 Mar 2000 - 
TL;DR: These findings provide the first in vivo evidence that the long‐term inhibition of PKC activation in the renal glomeruli can ameliorate glomerular pathologies in diabetic state, and suggest that a PKC β inhibitor might be an useful therapeutic strategy for the treatment of diabetic nephropathy.
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Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Cristian Pattaro, +735 more
- 21 Jan 2016 - 
TL;DR: A meta-analysis of genome-wide association studies for estimated glomerular filtration rate suggests that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.