K
Kotb Abdelmohsen
Researcher at National Institutes of Health
Publications - 163
Citations - 21231
Kotb Abdelmohsen is an academic researcher from National Institutes of Health. The author has contributed to research in topics: RNA-binding protein & Gene silencing. The author has an hindex of 63, co-authored 145 publications receiving 17825 citations. Previous affiliations of Kotb Abdelmohsen include Catalan Institution for Research and Advanced Studies & University of Maryland, Baltimore.
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Journal ArticleDOI
Regulation of senescence by microRNA biogenesis factors.
TL;DR: How miRNA biogenesis proteins promote or inhibit senescence, and thus influence the senescent phenotype that affects normal tissue function and pathology is discussed.
Journal ArticleDOI
Novel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity.
Peisu Zhang,Kotb Abdelmohsen,Yong Liu,Kumiko Tominaga-Yamanaka,Je-Hyun Yoon,Grammatikakis Ioannis,Jennifer L. Martindale,Yongqing Zhang,Kevin G. Becker,In Hong Yang,Myriam Gorospe,Mark P. Mattson,Mark P. Mattson +12 more
TL;DR: It is demonstrated that a non-telomeric isoform of telomere repeat-binding factor 2 (TRF2-S) is a novel RBP that regulates axonal plasticity and suggests a pivotal role for TRF1-S in an axonal mRNA localization pathway that enhances axon outgrowth and neurotransmitter release.
Journal ArticleDOI
AUF1 promotes let-7b loading on Argonaute 2.
Je-Hyun Yoon,Myung Hyun Jo,Elizabeth J.F. White,Supriyo De,Markus Hafner,Beth E. Zucconi,Kotb Abdelmohsen,Jennifer L. Martindale,Xiaoling Yang,William H. Wood,Yu Mi Shin,Ji-Joon Song,Thomas Tuschl,Kevin G. Becker,Gerald M. Wilson,Sungchul Hohng,Myriam Gorospe +16 more
TL;DR: These findings uncover a novel mechanism by which AUF1 binding and transfer of microRNA let-7 to AGO2 facilitatesLet-7-elicited gene silencing.
Journal ArticleDOI
dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer: a dual-institutional follow-up with the RTOG 9704 trial.
Florencia McAllister,Danielle M. Pineda,Masaya Jimbo,Shruti Lal,Richard A. Burkhart,Jennifer Moughan,Kathryn Winter,Kotb Abdelmohsen,Myriam Gorospe,Ana De Jesus Acosta,Rachana H. Lankapalli,Jordan M. Winter,Charles J. Yeo,Agnieska K. Witkiewicz,Christine A. Iacobuzio-Donahue,Daniel A. Laheru,Jonathan R. Brody +16 more
TL;DR: It is demonstrated that 5-FU can increase HuR function by enhancing HuR translocation from the nucleus to the cytoplasm, similar to the effect of gemcitabine in PDA cells.
Journal ArticleDOI
SCAMP4 enhances the senescent cell secretome.
Kyoung Mi Kim,Ji Heon Noh,Monica Bodogai,Jennifer L. Martindale,Poonam R. Pandey,Xiaoling Yang,Arya Biragyn,Kotb Abdelmohsen,Myriam Gorospe +8 more
TL;DR: The results indicate that SCAMP4 accumulates on the surface of senescent cells, promotes SASP factor secretion, and critically enhances the SASP phenotype.