K
Kotb Abdelmohsen
Researcher at National Institutes of Health
Publications - 163
Citations - 21231
Kotb Abdelmohsen is an academic researcher from National Institutes of Health. The author has contributed to research in topics: RNA-binding protein & Gene silencing. The author has an hindex of 63, co-authored 145 publications receiving 17825 citations. Previous affiliations of Kotb Abdelmohsen include Catalan Institution for Research and Advanced Studies & University of Maryland, Baltimore.
Papers
More filters
Journal ArticleDOI
Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination
Je-Hyun Yoon,Kotb Abdelmohsen,Jiyoung Kim,Xiaoling Yang,Jennifer L. Martindale,Kumiko Tominaga-Yamanaka,Elizabeth J.F. White,Arturo V. Orjalo,John L. Rinn,Stefan G. Kreft,Gerald M. Wilson,Myriam Gorospe +11 more
TL;DR: A post-translational function for the lncRNA HOTAIR is reported as an inducer of ubiquitin-mediated proteolysis, causing rapid decay of targets Ataxin-1 and Snurportin- 1, and preventing premature senescence.
Journal ArticleDOI
RNA in extracellular vesicles
TL;DR: The rising attention to EV‐resident RNAs as biomarkers stems from the fact that RNAs can be detected at extremely low quantities using a number of methods, and this work discusses EV RNAs in cancer and neurodegeneration, two major age‐associated disease processes.
Journal ArticleDOI
microRNA expression patterns reveal differential expression of target genes with age.
Nicole Noren Hooten,Kotb Abdelmohsen,Myriam Gorospe,Ngozi Ejiogu,Alan B. Zonderman,Michele K. Evans +5 more
TL;DR: It is demonstrated that changes in miRNA expression occur with human aging and suggest that miRNAs and their predicted targets have the potential to be diagnostic indicators of age or age-related diseases.
Journal ArticleDOI
miR-130 Suppresses Adipogenesis by Inhibiting Peroxisome Proliferator-Activated Receptor Expression
Eun Kyung Lee,Mi-Jeong Lee,Kotb Abdelmohsen,Wook Kim,Mihee M. Kim,Subramanya Srikantan,Jennifer L. Martindale,Emmette R. Hutchison,Hyeon Ho Kim,Bernard S. Marasa,Roza Selimyan,Josephine M. Egan,Steven R. Smith,Susan K. Fried,Myriam Gorospe +14 more
TL;DR: The findings reveal that miR-130 reduces adipogenesis by repressing PPARγ biosynthesis and suggest that perturbations in this regulation is linked to human obesity.
Journal ArticleDOI
Cytoplasmic functions of long noncoding RNAs.
TL;DR: The current knowledge of cytoplasmic lncRNAs and the different levels of gene regulation controlled by cytop lncRNA complexes are reviewed, including mRNA turnover, translation, protein stability, sponging of cytosolic factors, and modulation of signaling pathways.