K
Kris Young
Researcher at University of North Carolina at Chapel Hill
Publications - 4
Citations - 65
Kris Young is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 2, co-authored 4 publications receiving 55 citations.
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The PAGE Study: How genetic diversity improves our understanding of the architecture of complex traits
Genevieve L. Wojcik,Misa Graff,Katherine K. Nishimura,Ran Tao,Jeffrey Haessler,Christopher R. Gignoux,Heather M. Highland,Yesha Patel,Elena P. Sorokin,Christy L. Avery,Gillian M. Belbin,Stephanie A. Bien,Iona Cheng,Sinead Cullina,Chani J. Hodonsky,Yao Hu,Huckins Lm,Janina M. Jeff,Anne E. Justice,Jonathan M. Kocarnik,Unhee Lim,Bridget M Lin,Yingchang Lu,Sarah C. Nelson,Sung-Hyuk Park,Hannah Poisner,Michael Preuss,Melissa A. Richard,Claudia Schurmann,Veronica Wendy Setiawan,Alexandra Sockell,Karan Vahi,Abhishek Vishnu,Marie Verbanck,Ruth H. Walker,Kris Young,Niha Zubair,Acuna-Alonso,José Luis Ambite,Kathleen C. Barnes,Eric Boerwinkle,Erwin P. Bottinger,Carlos Bustamante,Christian Caberto,Canizales-Quinteroes S,Matthew P. Conomos,Ewa Deelman,Ron Do,Kimberly F. Doheny,Lindsay Fernández-Rhodes,Myriam Fornage,Gerardo Heiss,Brenna M. Henn,Lucia A. Hindorff,Rebecca D. Jackson,Benyam Hailu,Cecilia A. Laurie,Cathy C. Laurie,Yuqing Li,Danyu Lin,Andrés Moreno-Estrada,Girish N. Nadkarni,Paul Norman,Loreall Pooler,Alexander P. Reiner,Jane Romm,Sabati C,Karla Sandoval,Xin Sheng,E Stahl,Daniel O. Stram,Timothy A. Thornton,Christina L. Wassel,L R Wilkens,Cheryl A. Winkler,Sachiko Yoneyama,Steve Buyske,Christopher A. Haiman,Charles Kooperberg,Loic Le Marchand,Loos R,Tara C. Matise,Kari E. North,Ulrike Peters,Eimear E. Kenny,Christopher S. Carlson +85 more
TL;DR: The data shows strong evidence of effect-size heterogeneity across ancestries for published GWAS associations, substantial benefits for fine-mapping using diverse cohorts, and insights into clinical implications.
Journal ArticleDOI
BMI loci and longitudinal BMI from adolescence to young adulthood in an ethnically diverse cohort
Mariaelisa Graff,Kari E. North,Allyson Richardson,Kris Young,Angela L. Mazul,Heather M. Highland,Karen L. Mohlke,Leslie A. Lange,Ethan M. Lange,K. Mullan Harris,Penny Gordon-Larsen +10 more
TL;DR: The observed association between variants in/near FTO, MC4R, MTCH2, TFAP2B, SEC16B and TMEM18 with change in BMI from adolescence to young adulthood suggest that the genetic effect of BMI loci varies over time in a complex manner, highlighting the importance of investigating loci influencing obesity risk across the life course.
Journal ArticleDOI
Full title: A large-scale transcriptome-wide association study (TWAS) of 10 blood cell phenotypes reveals complexities of TWAS fine-mapping.
Amanda L. Tapia,Bryce Rowland,Jonathan D. Rosen,Michael Preuss,Kris Young,Misa Graff,Hélène Choquet,David Couper,Steve Buyske,Stephanie A. Bien,Eric Jorgenson,Charles Kooperberg,Ruth J. F. Loos,Alanna C. Morrison,Kari E. North,Bing Yu,Alexander P. Reiner,Yun Li,Laura M. Raffield +18 more
TL;DR: In this article, a transcriptome-wide association study (TWAS) was performed to investigate the association between genetically predicted gene expression and hematological measures in 54,542 Europeans from the Genetic Epidemiology Research on Aging cohort.
Posted ContentDOI
A large-scale transcriptome-wide association study (TWAS) of ten blood cell phenotypes reveals complexities of TWAS fine-mapping
Amanda L. Tapia,Bryce Rowland,Jonathan D. Rosen,Michael Preuss,Kris Young,Misa Graff,Hélène Choquet,David Couper,Steve Buyske,Stephanie A. Bien,Eric Jorgenson,Charles Kooperberg,Ruth J. F. Loos,Alanna C. Morrison,Kari E. North,Bing Yu,Alexander P. Reiner,Yun Li,Laura M. Raffield +18 more
TL;DR: In this paper, the authors performed a transcriptome-wide association study (TWAS) using PrediXcan to systematically investigate the association between genetically-predicted gene expression and hematological measures in 54,542 individuals of European ancestry from the Genetic Epidemiology Research on Adult Health and Aging cohort.