S
Sinead Cullina
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 16
Citations - 803
Sinead Cullina is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Population & Biobank. The author has an hindex of 7, co-authored 14 publications receiving 412 citations.
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Journal ArticleDOI
Genetic analyses of diverse populations improves discovery for complex traits
Genevieve L. Wojcik,Mariaelisa Graff,Katherine K. Nishimura,Ran Tao,Jeffrey Haessler,Christopher R. Gignoux,Christopher R. Gignoux,Heather M. Highland,Yesha Patel,Elena P. Sorokin,Christy L. Avery,Gillian M. Belbin,Stephanie A. Bien,Iona Cheng,Sinead Cullina,Chani J. Hodonsky,Yao Hu,Laura M. Huckins,Janina M. Jeff,Anne E. Justice,Jonathan M. Kocarnik,Unhee Lim,Bridget M Lin,Yingchang Lu,Sarah C. Nelson,Sungshim L. Park,Hannah Poisner,Michael Preuss,Melissa A. Richard,Claudia Schurmann,Claudia Schurmann,Veronica Wendy Setiawan,Alexandra Sockell,Karan Vahi,Marie Verbanck,Abhishek Vishnu,Ryan W. Walker,Kristin L. Young,Niha Zubair,Victor Acuña-Alonso,José Luis Ambite,Kathleen C. Barnes,Eric Boerwinkle,Erwin P. Bottinger,Erwin P. Bottinger,Carlos Bustamante,Christian Caberto,Samuel Canizales-Quinteros,Matthew P. Conomos,Ewa Deelman,Ron Do,Kimberly F. Doheny,Lindsay Fernández-Rhodes,Lindsay Fernández-Rhodes,Myriam Fornage,Benyam Hailu,Gerardo Heiss,Brenna M. Henn,Lucia A. Hindorff,Rebecca D. Jackson,Cecelia A. Laurie,Cathy C. Laurie,Yuqing Li,Yuqing Li,Danyu Lin,Andrés Moreno-Estrada,Girish N. Nadkarni,Paul Norman,Loreall Pooler,Alexander P. Reiner,Jane Romm,Chiara Sabatti,Karla Sandoval,Xin Sheng,Eli A. Stahl,Daniel O. Stram,Timothy A. Thornton,Christina L. Wassel,Lynne R. Wilkens,Cheryl A. Winkler,Sachi Yoneyama,Steven Buyske,Christopher A. Haiman,Charles Kooperberg,Loic Le Marchand,Ruth J. F. Loos,Tara C. Matise,Kari E. North,Ulrike Peters,Eimear E. Kenny,Christopher S. Carlson +90 more
TL;DR: The value of diverse, multi-ethnic participants in large-scale genomic studies is demonstrated and evidence of effect-size heterogeneity across ancestries for published GWAS associations, substantial benefits for fine-mapping using diverse cohorts and insights into clinical implications are shown.
Journal ArticleDOI
Exome sequencing reveals a high prevalence of BRCA1 and BRCA2 founder variants in a diverse population-based biobank.
Noura S. Abul-Husn,Emily R. Soper,Jacqueline A. Odgis,Sinead Cullina,Dean Bobo,Arden Moscati,Jessica E. Rodriguez,Ruth J. F. Loos,Judy H. Cho,Gillian M. Belbin,Sabrina A. Suckiel,Eimear E. Kenny +11 more
TL;DR: Investigating BRCA1/2 prevalence and impact in the EHR-linked BioMe Biobank in New York City indicates a gap in knowledge about potential cancer-related variants in non-European populations, and suggests that genomic screening in diverse patient populations may be an effective tool to identify at-risk individuals.
Journal ArticleDOI
Toward a fine-scale population health monitoring system.
Gillian M. Belbin,Sinead Cullina,Stephane Wenric,Emily R. Soper,Benjamin S. Glicksberg,Denis Torre,Arden Moscati,Genevieve L. Wojcik,Ruhollah Shemirani,Noam D. Beckmann,Ariella Cohain,Elena P. Sorokin,Danny S. Park,José Luis Ambite,Steve Ellis,Adam Auton,Cbipm Genomics Team,Erwin P. Bottinger,Judy H. Cho,Ruth J. F. Loos,Noura S. Abul-Husn,Noah Zaitlen,Christopher R. Gignoux,Eimear E. Kenny +23 more
TL;DR: A framework for repurposing data from EHRs in concert with genomic data to explore the demographic ties that can impact disease burdens and demonstrates that fine-scale population structure can impact the prediction of complex disease risk within groups.
Posted ContentDOI
The PAGE Study: How genetic diversity improves our understanding of the architecture of complex traits
Genevieve L. Wojcik,Misa Graff,Katherine K. Nishimura,Ran Tao,Jeffrey Haessler,Christopher R. Gignoux,Heather M. Highland,Yesha Patel,Elena P. Sorokin,Christy L. Avery,Gillian M. Belbin,Stephanie A. Bien,Iona Cheng,Sinead Cullina,Chani J. Hodonsky,Yao Hu,Huckins Lm,Janina M. Jeff,Anne E. Justice,Jonathan M. Kocarnik,Unhee Lim,Bridget M Lin,Yingchang Lu,Sarah C. Nelson,Sung-Hyuk Park,Hannah Poisner,Michael Preuss,Melissa A. Richard,Claudia Schurmann,Veronica Wendy Setiawan,Alexandra Sockell,Karan Vahi,Abhishek Vishnu,Marie Verbanck,Ruth H. Walker,Kris Young,Niha Zubair,Acuna-Alonso,José Luis Ambite,Kathleen C. Barnes,Eric Boerwinkle,Erwin P. Bottinger,Carlos Bustamante,Christian Caberto,Canizales-Quinteroes S,Matthew P. Conomos,Ewa Deelman,Ron Do,Kimberly F. Doheny,Lindsay Fernández-Rhodes,Myriam Fornage,Gerardo Heiss,Brenna M. Henn,Lucia A. Hindorff,Rebecca D. Jackson,Benyam Hailu,Cecilia A. Laurie,Cathy C. Laurie,Yuqing Li,Danyu Lin,Andrés Moreno-Estrada,Girish N. Nadkarni,Paul Norman,Loreall Pooler,Alexander P. Reiner,Jane Romm,Sabati C,Karla Sandoval,Xin Sheng,E Stahl,Daniel O. Stram,Timothy A. Thornton,Christina L. Wassel,L R Wilkens,Cheryl A. Winkler,Sachiko Yoneyama,Steve Buyske,Christopher A. Haiman,Charles Kooperberg,Loic Le Marchand,Loos R,Tara C. Matise,Kari E. North,Ulrike Peters,Eimear E. Kenny,Christopher S. Carlson +85 more
TL;DR: The data shows strong evidence of effect-size heterogeneity across ancestries for published GWAS associations, substantial benefits for fine-mapping using diverse cohorts, and insights into clinical implications.
Posted ContentDOI
Towards a fine-scale population health monitoring system
Gillian M. Belbin,Stephane Wenric,Sinead Cullina,Benjamin S. Glicksberg,Arden Moscati,Genevieve L. Wojcik,Ruhollah Shemirani,Noam D. Beckmann,Ariella Cohain,Elena P. Sorokin,Danny S. Park,Danny S. Park,José Luis Ambite,Steve Ellis,Adam Auton,Cbipm Genomics Team,Erwin P. Bottinger,Judy H. Cho,Ruth J. F. Loos,Noura S. Abul-Husn,Noah Zaitlen,Christopher R. Gignoux,Eimear E. Kenny +22 more
TL;DR: In this article, a framework for repurposing data from Electronic Health Records (EHRs) in concert with genomic data to explore enrichment of disease within sub-populations was proposed.