G
Genevieve L. Wojcik
Researcher at Johns Hopkins University
Publications - 84
Citations - 3605
Genevieve L. Wojcik is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 19, co-authored 65 publications receiving 2068 citations. Previous affiliations of Genevieve L. Wojcik include Stanford University.
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Journal ArticleDOI
Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations
Alicia R. Martin,Christopher R. Gignoux,Raymond K. Walters,Genevieve L. Wojcik,Benjamin M. Neale,Benjamin M. Neale,Simon Gravel,Mark J. Daly,Mark J. Daly,Carlos Bustamante,Eimear E. Kenny +10 more
TL;DR: It is demonstrated that scores inferred from European GWASs are biased by genetic drift in other populations even when choosing the same causal variants and that biases in any direction are possible and unpredictable.
Journal ArticleDOI
Genetic analyses of diverse populations improves discovery for complex traits
Genevieve L. Wojcik,Mariaelisa Graff,Katherine K. Nishimura,Ran Tao,Jeffrey Haessler,Christopher R. Gignoux,Christopher R. Gignoux,Heather M. Highland,Yesha Patel,Elena P. Sorokin,Christy L. Avery,Gillian M. Belbin,Stephanie A. Bien,Iona Cheng,Sinead Cullina,Chani J. Hodonsky,Yao Hu,Laura M. Huckins,Janina M. Jeff,Anne E. Justice,Jonathan M. Kocarnik,Unhee Lim,Bridget M Lin,Yingchang Lu,Sarah C. Nelson,Sungshim L. Park,Hannah Poisner,Michael Preuss,Melissa A. Richard,Claudia Schurmann,Claudia Schurmann,Veronica Wendy Setiawan,Alexandra Sockell,Karan Vahi,Marie Verbanck,Abhishek Vishnu,Ryan W. Walker,Kristin L. Young,Niha Zubair,Victor Acuña-Alonso,José Luis Ambite,Kathleen C. Barnes,Eric Boerwinkle,Erwin P. Bottinger,Erwin P. Bottinger,Carlos Bustamante,Christian Caberto,Samuel Canizales-Quinteros,Matthew P. Conomos,Ewa Deelman,Ron Do,Kimberly F. Doheny,Lindsay Fernández-Rhodes,Lindsay Fernández-Rhodes,Myriam Fornage,Benyam Hailu,Gerardo Heiss,Brenna M. Henn,Lucia A. Hindorff,Rebecca D. Jackson,Cecelia A. Laurie,Cathy C. Laurie,Yuqing Li,Yuqing Li,Danyu Lin,Andrés Moreno-Estrada,Girish N. Nadkarni,Paul Norman,Loreall Pooler,Alexander P. Reiner,Jane Romm,Chiara Sabatti,Karla Sandoval,Xin Sheng,Eli A. Stahl,Daniel O. Stram,Timothy A. Thornton,Christina L. Wassel,Lynne R. Wilkens,Cheryl A. Winkler,Sachi Yoneyama,Steven Buyske,Christopher A. Haiman,Charles Kooperberg,Loic Le Marchand,Ruth J. F. Loos,Tara C. Matise,Kari E. North,Ulrike Peters,Eimear E. Kenny,Christopher S. Carlson +90 more
TL;DR: The value of diverse, multi-ethnic participants in large-scale genomic studies is demonstrated and evidence of effect-size heterogeneity across ancestries for published GWAS associations, substantial benefits for fine-mapping using diverse cohorts and insights into clinical implications are shown.
Journal ArticleDOI
Improving reporting standards for polygenic scores in risk prediction studies
Hannah Wand,Samuel A. Lambert,Cecelia P. Tamburro,Michael A. Iacocca,Jack W. O’Sullivan,Catherine Sillari,Iftikhar J. Kullo,Robb Rowley,Jacqueline S. Dron,Jacqueline S. Dron,Deanna Brockman,Eric Venner,Mark I McCarthy,Mark I McCarthy,Antonis C. Antoniou,Douglas F. Easton,Robert A. Hegele,Amit Khera,Nilanjan Chatterjee,Charles Kooperberg,Karen Edwards,Katherine Vlessis,Kim Kinnear,John Danesh,John Danesh,Helen Parkinson,Helen Parkinson,Erin M. Ramos,Megan C. Roberts,Kelly E. Ormond,Muin J. Khoury,A. Cecile J.W. Janssens,Katrina A.B. Goddard,Peter Kraft,Jacqueline Al MacArthur,Michael Inouye,Genevieve L. Wojcik +36 more
TL;DR: The Polygenic Risk Score Reporting Standards (PRS-RS) as discussed by the authors is a comprehensive reporting framework that defines the minimal information that is needed to interpret and evaluate PRSs, especially with respect to downstream clinical applications.
Journal ArticleDOI
Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts
Priya Duggal,Chloe L. Thio,Genevieve L. Wojcik,James J. Goedert,Alessandra Mangia,Rachel Latanich,Arthur Y. Kim,Georg M. Lauer,Raymond T. Chung,Marion G. Peters,Gregory D. Kirk,Shruti H. Mehta,Andrea L. Cox,Salim I. Khakoo,Laurent Alric,Matthew E. Cramp,Sharyne M. Donfield,Brian R. Edlin,Leslie H. Tobler,Michael P. Busch,Graeme J.M. Alexander,Hugo R. Rosen,Xiaojiang Gao,Mohamed Abdel-Hamid,Richard Apps,Mary Carrington,David L. Thomas +26 more
TL;DR: IL-28B and HLA class II are independently associated with spontaneous resolution of HCV infection, and SNPs marking IL-28 B and DQB1*03:01 may explain approximately 15% of spontaneous resolution in persons of European and African ancestry.
Journal ArticleDOI
Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps
Adebowale Adeyemo,Mary K. Balaconis,Deanna R. Darnes,Segun Fatumo,Palmira Granados Moreno,Chani J. Hodonsky,Michael Inouye,Masahiro Kanai,Kazuto Kato,Bartha Maria Knoppers,Anna C. F. Lewis,Alicia R. Martin,Mark I. McCarthy,Michelle N. Meyer,Yukinori Okada,J. Brent Richards,Lucas Richter,Samuli Ripatti,Charles N. Rotimi,Saskia C. Sanderson,Amy C. Sturm,Ricardo A. Verdugo,Elisabeth Widen,Cristen J. Willer,Genevieve L. Wojcik,Alicia Zhou +25 more