Melissa A. Richard

TL;DR: In insights into the role of alcohol consumption in the genetic architecture of hypertension, a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions is conducted.

TL;DR: The value of diverse, multi-ethnic participants in large-scale genomic studies is demonstrated and evidence of effect-size heterogeneity across ancestries for published GWAS associations, substantial benefits for fine-mapping using diverse cohorts and insights into clinical implications are shown.

TL;DR: A two-stage meta-analysis of the cross-sectional associations of systolic and diastolic BP with blood-derived genome-wide DNA methylation measured on the Infinium HumanMethylation450 BeadChip suggests that heritableDNA methylation plays a role in regulating BP independently of previously known genetic variants.

TL;DR: The authors perform GWAS for DNA methylation in whole blood, cis- and trans-meQTL mapping, followed by Mendelian randomization analysis that links meQTLs with cardiovascular diseases, and shed light on DNA methylated CpGs involvement in human diseases.

TL;DR: The identified loci show strong evidence for regulatory features and support shared pathophysiology with cardiometabolic and addiction traits and highlight a role in BP regulation for biological candidates such as modulators of vascular structure and function.