L
Laura H Duncan
Researcher at North Carolina State University
Publications - 8
Citations - 2563
Laura H Duncan is an academic researcher from North Carolina State University. The author has contributed to research in topics: Candidate gene & Gene. The author has an hindex of 6, co-authored 7 publications receiving 2316 citations. Previous affiliations of Laura H Duncan include University of Southern California.
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Journal ArticleDOI
The Drosophila melanogaster Genetic Reference Panel
Trudy F. C. Mackay,Stephen Richards,Eric A. Stone,Antonio Barbadilla,Julien F. Ayroles,Julien F. Ayroles,Dianhui Zhu,Sònia Casillas,Yi Han,Michael M. Magwire,Julie M. Cridland,Mark F. Richardson,Robert R. H. Anholt,Maite G. Barrón,Crystal Bess,Kerstin P. Blankenburg,Mary Anna Carbone,David Castellano,Lesley S. Chaboub,Laura H Duncan,Zeke Harris,Mehwish Javaid,Joy Jayaseelan,Shalini N. Jhangiani,Katherine W. Jordan,Fremiet Lara,Faye Lawrence,Sandra L. Lee,Pablo Librado,Raquel S. Linheiro,Richard F. Lyman,Aaron J. Mackey,Mala Munidasa,Donna M. Muzny,Lynne V. Nazareth,Irene Newsham,Lora Perales,Ling-Ling Pu,Carson Qu,Miquel Ràmia,Jeffrey G. Reid,Stephanie M. Rollmann,Stephanie M. Rollmann,Julio Rozas,Nehad Saada,Lavanya Turlapati,Kim C. Worley,Yuanqing Wu,Akihiko Yamamoto,Yiming Zhu,Casey M. Bergman,Kevin R. Thornton,David Mittelman,Richard A. Gibbs +53 more
TL;DR: The Drosophila melanogaster Genetic Reference Panel is described, a community resource for analysis of population genomics and quantitative traits, which reveals reduced polymorphism in centromeric autosomal regions and the X chromosomes, evidence for positive and negative selection, and rapid evolution of the X chromosome.
Journal ArticleDOI
Systems genetics of complex traits in Drosophila melanogaster.
Julien F. Ayroles,Mary Anna Carbone,Eric A. Stone,Katherine W. Jordan,Richard F. Lyman,Michael M. Magwire,Michael M. Magwire,Stephanie M. Rollmann,Stephanie M. Rollmann,Laura H Duncan,Faye Lawrence,Robert R. H. Anholt,Trudy F. C. Mackay +12 more
TL;DR: The authors quantified genome-wide transcript abundance and phenotypes for six ecologically relevant traits in D. melanogaster wild-derived inbred lines and observed 10,096 genetically variable transcripts and high heritabilities for all organismal phenotypes.
Journal ArticleDOI
Epistasis dominates the genetic architecture of Drosophila quantitative traits.
Wen Huang,Stephen Richards,Mary Anna Carbone,Dianhui Zhu,Robert R. H. Anholt,Julien F. Ayroles,Laura H Duncan,Katherine W. Jordan,Faye Lawrence,Michael M. Magwire,Crystal B. Warner,Kerstin P. Blankenburg,Yi Han,Mehwish Javaid,Joy Jayaseelan,Shalini N. Jhangiani,Donna M. Muzny,Fiona Ongeri,Lora Perales,Yuan Qing Wu,Yiqing Zhang,Xiaoyan Zou,Eric A. Stone,Richard A. Gibbs,Trudy F. C. Mackay +24 more
TL;DR: In this article, the authors compared the genetic architecture of three Drosophila life history traits in the sequenced inbred lines of the melanogaster Genetic Reference Panel (DGRP) and a large outbred, advanced intercross population derived from 40 DGRP lines (Flyland).
Journal ArticleDOI
The Genomic Basis of Postponed Senescence in Drosophila melanogaster
Megan U. Carnes,Terry Campbell,Wen Huang,Daniel G. Butler,Mary Anna Carbone,Laura H Duncan,Sasha V. Harbajan,Edward M. King,Kara R. Peterson,Alexander Weitzel,Shanshan Zhou,Trudy F. C. Mackay +11 more
TL;DR: The genetic divergence between five Drosophila melanogaster lines selected for postponed senescence for over 170 generations and five lines from the same base population maintained at a two week generation interval for over 850 generations is assessed.
Journal ArticleDOI
Alcohol sensitivity in Drosophila: translational potential of systems genetics.
Tatiana V. Morozova,Julien F. Ayroles,Katherine W. Jordan,Laura H Duncan,Mary Anna Carbone,Richard F Lyman,Eric A. Stone,Eric A. Stone,Diddahally R Govindaraju,R. Curtis Ellison,Trudy F. C. Mackay,Robert R. H. Anholt +11 more
TL;DR: Seven intronic single nucleotide polymorphisms of the Malic Enzyme 1 (ME1) gene that are associated with cocktail drinking in 1687 individuals of the Framingham Offspring cohort are identified, implicating that variation in levels of cytoplasmic malic enzyme may contribute to variation in alcohol consumption.