V
Vicki H. Wysocki
Researcher at Ohio State University
Publications - 304
Citations - 14524
Vicki H. Wysocki is an academic researcher from Ohio State University. The author has contributed to research in topics: Mass spectrometry & Dissociation (chemistry). The author has an hindex of 60, co-authored 273 publications receiving 12838 citations. Previous affiliations of Vicki H. Wysocki include Scripps Research Institute & University of California, Santa Barbara.
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Journal ArticleDOI
Mobile and localized protons: a framework for understanding peptide dissociation
TL;DR: In this paper, surface-induced dissociation, along with gas-phase collision-induced disociation performed under a variety of conditions, has been used to refine the general'mobile proton' model and to determine how and why enhanced cleavages occur at aspartic acid residues and protonated histidine residues.
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Influence of Peptide Composition, Gas-Phase Basicity, and Chemical Modification on Fragmentation Efficiency: Evidence for the Mobile Proton Model
TL;DR: The relative positions of the ESI/SID fragmentation efficiency curves depend on several parameters which include peptide composition (e.g., presence/absence of a basic amino acid residue) and peptide size.
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How many human proteoforms are there
Ruedi Aebersold,Jeffrey N. Agar,I. Jonathan Amster,Mark S. Baker,Carolyn R. Bertozzi,Emily S. Boja,Catherine E. Costello,Benjamin F. Cravatt,Catherine Fenselau,Benjamin A. Garcia,Ying Ge,Jeremy Gunawardena,Ronald C. Hendrickson,Paul J. Hergenrother,Christian G. Huber,Alexander R. Ivanov,Ole N. Jensen,Michael C. Jewett,Neil L. Kelleher,Laura L. Kiessling,Nevan J. Krogan,Martin R. Larsen,Joseph A. Loo,Rachel R. Ogorzalek Loo,Emma Lundberg,Emma Lundberg,Michael J. MacCoss,Parag Mallick,Vamsi K. Mootha,Milan Mrksich,Tom W. Muir,Steven M. Patrie,James J. Pesavento,Sharon J. Pitteri,Henry Rodriguez,Alan Saghatelian,Wendy Sandoval,Hartmut Schlüter,Salvatore Sechi,Sarah A. Slavoff,Lloyd M. Smith,Michael Snyder,Paul M. Thomas,Mathias Uhlén,Jennifer E. Van Eyk,Marc Vidal,David R. Walt,Forest M. White,Evan R. Williams,Therese Wohlschlager,Vicki H. Wysocki,Nathan A. Yates,Nicolas L. Young,Bing Zhang +53 more
TL;DR: This work frames central issues regarding determination of protein-level variation and PTMs, including some paradoxes present in the field today, and uses this framework to assess existing data and ask the question, "How many distinct primary structures of proteins (proteoforms) are created from the 20,300 human genes?"
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Interface Dipoles Arising from Self-Assembled Monolayers on Gold: UV−Photoemission Studies of Alkanethiols and Partially Fluorinated Alkanethiols
Dana M. Alloway,Michael Hofmann,Michael Hofmann,Darrin L. Smith,Nadine E. Gruhn,Amy L. Graham,Ramon Colorado,Vicki H. Wysocki,T. Randall Lee,Paul A. Lee,Neal R. Armstrong +10 more
TL;DR: In this paper, the effect of alkanethiols on the effective work function of gold surfaces was analyzed using X-ray photo-electron spectroscopy, showing an exponential decrease in emission intensity versus alkyl chain length.
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Mass spectrometry of peptides and proteins.
TL;DR: The most widely used ion activation and dissociation process, gas-phase collision-activated dissociation (CAD), is discussed from a practical point of view and the influence of instrumental methods on the fragmentation pathways and final spectra are discussed.