S
Sarah A. Slavoff
Researcher at Yale University
Publications - 39
Citations - 2570
Sarah A. Slavoff is an academic researcher from Yale University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 15, co-authored 31 publications receiving 1783 citations. Previous affiliations of Sarah A. Slavoff include University of Maryland, College Park & Harvard University.
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Journal ArticleDOI
Peptidomic discovery of short open reading frame–encoded peptides in human cells
Sarah A. Slavoff,Andrew J. Mitchell,Adam G. Schwaid,Moran N. Cabili,Moran N. Cabili,Jiao Ma,Joshua Z. Levin,Amir Karger,Bogdan Budnik,John L. Rinn,John L. Rinn,Alan Saghatelian +11 more
TL;DR: A peptidomic strategy to detect short ORF (sORF)-encoded polypeptides (SEPs) in human cells is developed, and 90 SEPs are identified, 86 of which are novel, the largest number of human SEPs ever reported.
Journal ArticleDOI
How many human proteoforms are there
Ruedi Aebersold,Jeffrey N. Agar,I. Jonathan Amster,Mark S. Baker,Carolyn R. Bertozzi,Emily S. Boja,Catherine E. Costello,Benjamin F. Cravatt,Catherine Fenselau,Benjamin A. Garcia,Ying Ge,Jeremy Gunawardena,Ronald C. Hendrickson,Paul J. Hergenrother,Christian G. Huber,Alexander R. Ivanov,Ole N. Jensen,Michael C. Jewett,Neil L. Kelleher,Laura L. Kiessling,Nevan J. Krogan,Martin R. Larsen,Joseph A. Loo,Rachel R. Ogorzalek Loo,Emma Lundberg,Emma Lundberg,Michael J. MacCoss,Parag Mallick,Vamsi K. Mootha,Milan Mrksich,Tom W. Muir,Steven M. Patrie,James J. Pesavento,Sharon J. Pitteri,Henry Rodriguez,Alan Saghatelian,Wendy Sandoval,Hartmut Schlüter,Salvatore Sechi,Sarah A. Slavoff,Lloyd M. Smith,Michael Snyder,Paul M. Thomas,Mathias Uhlén,Jennifer E. Van Eyk,Marc Vidal,David R. Walt,Forest M. White,Evan R. Williams,Therese Wohlschlager,Vicki H. Wysocki,Nathan A. Yates,Nicolas L. Young,Bing Zhang +53 more
TL;DR: This work frames central issues regarding determination of protein-level variation and PTMs, including some paradoxes present in the field today, and uses this framework to assess existing data and ask the question, "How many distinct primary structures of proteins (proteoforms) are created from the 20,300 human genes?"
Journal ArticleDOI
P-Bodies: Composition, Properties, and Functions
TL;DR: Recent advances in understanding of the molecular composition of P-bodies, the interactions and processes that regulate P-body liquid–liquid phase separation (LLPS), and the cellular localization of mRNA decay machinery are reviewed in the context of how these discoveries refine models ofP-body function.
Journal ArticleDOI
A human microprotein that interacts with the mRNA decapping complex
Nadia G. D'Lima,Jiao Ma,Lauren Winkler,Qian Chu,Ken H Loh,Elizabeth O. Corpuz,Bogdan Budnik,Jens Lykke-Andersen,Alan Saghatelian,Sarah A. Slavoff +9 more
TL;DR: Modulation of NoBody levels reveals that its abundance is anti-correlated with cellular P-body numbers and alters the steady-state levels of a cellular NMD substrate, implicate NoBody as a novel component of the mRNA decapping complex and demonstrate potential functionality of a newly discovered microprotein.
Journal ArticleDOI
Discovery of human sORF-encoded polypeptides (SEPs) in cell lines and tissue.
Jiao Ma,Carl C. Ward,Irwin Jungreis,Irwin Jungreis,Sarah A. Slavoff,Adam G. Schwaid,John M. Neveu,Bogdan Budnik,Manolis Kellis,Manolis Kellis,Alan Saghatelian +10 more
TL;DR: The existence of nonannotated protein-coding human short open reading frames (sORFs) has been revealed through the direct detection of their sORF-encoded polypeptide (SEP) products as mentioned in this paper.