L
Laura Polakowski
Researcher at National Institutes of Health
Publications - 7
Citations - 3072
Laura Polakowski is an academic researcher from National Institutes of Health. The author has contributed to research in topics: HIV vaccine & Medicine. The author has an hindex of 4, co-authored 6 publications receiving 2763 citations.
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Journal ArticleDOI
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Lindsey R. Baden,Hana M. El Sahly,Brandon Essink,Karen L. Kotloff,Sharon E. Frey,Rick Novak,David Diemert,Stephen A. Spector,Nadine Rouphael,C. Buddy Creech,John W McGettigan,Shishir Khetan,Nathan Segall,Joel Solis,Adam Brosz,Carlos Fierro,Howard J. Schwartz,Kathleen M. Neuzil,Lawrence Corey,Peter B. Gilbert,Holly Janes,Dean Follmann,Mary A. Marovich,John R. Mascola,Laura Polakowski,Julie E. Ledgerwood,Barney S. Graham,Hamilton Bennett,Rolando Pajon,Conor Knightly,Brett Leav,Weiping Deng,Honghong Zhou,Shu Liang Han,Melanie Ivarsson,Jacqueline Miller,Tal Z Zaks +36 more
TL;DR: The mRNA-1273 vaccine as discussed by the authors is a lipid nanoparticle-encapsulated mRNA-based vaccine that encodes the prefusion stabilized full-length spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Covid-19.
Journal ArticleDOI
Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase.
Hana M. El Sahly,Lindsey R. Baden,Brandon Essink,Susanne Doblecki-Lewis,Judith M. Martin,Evan J. Anderson,Thomas B. Campbell,Jesse L. Clark,Lisa A. Jackson,Carl J. Fichtenbaum,Marcus J. Zervos,Bruce Rankin,Frank Eder,Gregory Feldman,Christina Kennelly,Laurie Han-Conrad,Michael Levin,Kathleen M. Neuzil,Lawrence Corey,Peter B. Gilbert,Holly Janes,Dean Follmann,Mary A. Marovich,Laura Polakowski,John R. Mascola,Julie E. Ledgerwood,Barney S. Graham,Allison August,Heather Clouting,Weiping Deng,Shu Han,Brett Leav,Deb Manzo,Rolando Pajon,Florian Schödel,Joanne E Tomassini,Honghong Zhou,Jacqueline M. Miller +37 more
TL;DR: The mRNA-1273 vaccine showed 94.1% efficacy in preventing coronavirus disease 2019 (Covid-... as discussed by the authors ) in a phase 3, observer-blinded, placebo-controlled clinical trial.
Journal ArticleDOI
Robust antibody and cellular responses induced by DNA-only vaccination for HIV
Stephen C. De Rosa,Stephen C. De Rosa,Srilatha Edupuganti,Yunda Huang,Yunda Huang,Xue Han,Marnie Elizaga,Edith Swann,Laura Polakowski,Spyros A. Kalams,Michael C. Keefer,Janine Maenza,Janine Maenza,Yiwen Lu,Megan C. Wise,Jian Yan,Matthew P. Morrow,Amir S. Khan,Jean D. Boyer,Laurent Humeau,Scott R. White,Michael Pensiero,Niranjan Y. Sardesai,Mark L. Bagarazzi,David B. Weiner,Guido Ferrari,Georgia D. Tomaras,David C. Montefiori,Lawrence Corey,M. Juliana McElrath +29 more
TL;DR: ID/EP was dose-sparing, inducing equivalent, or in some aspects superior, immune responses compared to IM/EP, demonstrating that immunogenicity of DNA vaccines can be enhanced by EP route and inclusion of pIL-12.
Journal ArticleDOI
Intramuscular and Intradermal Electroporation of HIV-1 PENNVAX-GP® DNA Vaccine and IL-12 Is Safe, Tolerable, Acceptable in Healthy Adults
Srilatha Edupuganti,Stephen C. De Rosa,Stephen C. De Rosa,Marnie Elizaga,Yiwen Lu,Xue Han,Yunda Huang,Yunda Huang,Edith Swann,Laura Polakowski,Spyros A. Kalams,Michael C. Keefer,Janine Maenza,Janine Maenza,Megan C. Wise,Jian Yan,Matthew P. Morrow,Amir S. Khan,Jean D. Boyer,Laurent Humeau,Scott R. White,Niranjan Y. Sardesai,Mark L. Bagarazzi,Peter B. Gilbert,James G. Kublin,Lawrence Corey,David B. Weiner +26 more
TL;DR: ID/EP and IM/EP are distinct experiences; however, HIV-1 DNA vaccination by either route was safe, tolerable and acceptable by most study participants.
Journal ArticleDOI
Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans.
Kelly E. Seaton,Aaron Deal,Xue Han,Shuying S. Li,Ashley Clayton,Jack Heptinstall,Jack Heptinstall,Ann Duerr,Mary Allen,Xiaoying Shen,Sheetal Sawant,Sheetal Sawant,Nicole L. Yates,Nicole L. Yates,Paul Spearman,Gavin J. Churchyard,Paul A. Goepfert,Janine Maenza,Janine Maenza,Glenda Gray,Glenda Gray,Giuseppe Pantaleo,Laura Polakowski,Harriet L. Robinson,Shannon Grant,April K. Randhawa,Ying Huang,Ying Huang,Cecilia Morgan,Nicole Grunenberg,Shelly Karuna,Peter B. Gilbert,Peter B. Gilbert,M. Juliana McElrath,Yunda Huang,Yunda Huang,Georgia D. Tomaras +36 more
TL;DR: In this article, the authors measured HIV-1-specific IgG and IgA in secretions from cervical and rectal swabs and compared to corresponding blood levels, and found that protein-containing regimens had up to 100% response rates and the highest Env-specific immune response rates.