L
Laurent Kremer
Researcher at French Institute of Health and Medical Research
Publications - 306
Citations - 14523
Laurent Kremer is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Mycobacterium abscessus & Mycobacterium tuberculosis. The author has an hindex of 62, co-authored 271 publications receiving 12447 citations. Previous affiliations of Laurent Kremer include University of Montpellier & Pasteur Institute.
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Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria.
Anil K. Ojha,Anthony D. Baughn,Dhinakaran Sambandan,Tsungda Hsu,Xavier Trivelli,Yann Guérardel,Anuradha Alahari,Laurent Kremer,William R. Jacobs,Graham F. Hatfull +9 more
TL;DR: It is shown that M. tuberculosis forms biofilms with specific environmental and genetic requirements distinct from those for planktonic growth, which contain an extracellular matrix rich in free mycolic acids, and harbour an important drug‐tolerant population that persist despite exposure to high levels of antibiotics.
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Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
TL;DR: It is hypothesized that the LAM/LM ratio might be a crucial factor in determining the virulence of a mycobacterial species and the outcome of the infection.
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GroEL1: A Dedicated Chaperone Involved in Mycolic Acid Biosynthesis during Biofilm Formation in Mycobacteria
TL;DR: Mycobacteria are unusual in encoding two GroEL paralogs, GroEL1 and GroEL2, which modulates synthesis of mycolates during biofilm formation and physically associates with KasA, a key component of the type II Fatty Acid Synthase involved in mycolic acid synthesis.
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Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus.
TL;DR: The proposed infection process of M. abscessus, its virulence factors and host interactions, mechanisms of drug resistance and drug development are discussed and the commonalities and differences are highlighted with other NTM species.
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Mycobacterium abscessus cording prevents phagocytosis and promotes abscess formation
Audrey Bernut,Jean-Louis Herrmann,Karima Kissa,Jean-François Dubremetz,Jean-Louis Gaillard,Georges Lutfalla,Laurent Kremer +6 more
TL;DR: It is demonstrated that extracellular cording allows the bacterium to withstand phagocytosis, leading to uncontrolled growth and establishment of an acute and lethal infection, thus constituting a determinant of virulence.