L
Lee Rowen
Researcher at Institute for Systems Biology
Publications - 65
Citations - 35324
Lee Rowen is an academic researcher from Institute for Systems Biology. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 39, co-authored 62 publications receiving 32743 citations. Previous affiliations of Lee Rowen include University of Washington & California Institute of Technology.
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Journal ArticleDOI
Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19.
Yapeng Su,Daniel Chen,Dan Yuan,Christopher Lausted,Jongchan Choi,Chengzhen L. Dai,Valentin Voillet,Venkata R Duvvuri,Kelsey Scherler,Pamela Troisch,Priyanka Baloni,Guangrong Qin,Brett Smith,Sergey A. Kornilov,Clifford Rostomily,Alexander M. Xu,Jing Li,Shen Dong,Alissa C. Rothchild,Jing Zhou,Kim Murray,Rick Edmark,Sunga Hong,John E. Heath,John C. Earls,Rongyu Zhang,Jingyi Xie,Sarah Li,Ryan Roper,Lesley Jones,Yong Zhou,Lee Rowen,Rachel Liu,Sean Mackay,D. Shane O’Mahony,Christopher R. Dale,Julie A. Wallick,Heather A. Algren,Michael Zager,Wei Wei,Nathan D. Price,Sui Huang,Naeha Subramanian,Kai Wang,Andrew T. Magis,Jenn J. Hadlock,Leroy Hood,Alan Aderem,Jeffrey A. Bluestone,Lewis L. Lanier,Philip D. Greenberg,Raphael Gottardo,Mark M. Davis,Jason D Goldman,James R. Heath +54 more
TL;DR: It is suggested that moderate disease may provide the most effective setting for therapeutic intervention, at which point elevated inflammatory signaling is accompanied by the loss of specific classes of metabolites and metabolic processes at moderate disease.
Journal ArticleDOI
A provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo.
Eric H. Davidson,Jonathan P. Rast,Paola Oliveri,Andrew Ransick,Cristina Calestani,Chiou-Hwa Yuh,Takuya Minokawa,Gabriele Amore,Veronica F. Hinman,Cesar Arenas-Mena,Ochan Otim,C. Titus Brown,Carolina B. Livi,Pei Yun Lee,Roger Revilla,Maria J. Schilstra,Peter J.C. Clarke,Alistair G. Rust,Zhengjun Pan,Maria Ina Arnone,Lee Rowen,R. Andrew Cameron,David R. McClay,Leroy Hood,Hamid Bolouri +24 more
TL;DR: The current form of a provisional DNA sequence-based regulatory gene network that explains in outline how endomesodermal specification in the sea urchin embryo is controlled is presented.
Journal ArticleDOI
Integration of cytogenetic landmarks into the draft sequence of the human genome
Vivian G. Cheung,Norma J. Nowak,Wonhee Jang,Ilan R. Kirsch,Shaying Zhao,Xiao Ning Chen,Terrence S. Furey,U. J. Kim,W. L. Kuo,M. Olvier,Jeffrey M. Conroy,Arek Kasprzyk,Hillary Massa,Raluca Yonescu,Sheilla Sait,Carson C. Thoreen,Carson C. Thoreen,Antoine M. Snijders,Emmanuelle Lemyre,Jeffrey A. Bailey,Alan Bruzel,W. D. Burrill,S. M. Clegg,S. Collins,P. Dhami,Cynthia Friedman,Cliff Han,Steven R. Herrick,Jonghyeob Lee,Azra H. Ligon,S. Lowry,M. Moriey,S. Narasimhan,Kazutoyo Osoegawa,Kazutoyo Osoegawa,Ze Peng,Ingrid Plajzer-Frick,Bradley J. Quade,D. Scott,Karl Sirotkin,A. A. Thorpe,Joe W. Gray,James R. Hudson,Daniel Pinkel,Thomas Ried,Lee Rowen,G. L. Shen-Ong,Robert L. Strausberg,Ewan Birney,David F. Callen,Jan Fang Cheng,David R. Cox,Norman A. Doggett,N. P. Carter,Evan E. Eichler,David Haussler,Julie R. Korenberg,Cynthia C. Morton,Donna G. Albertson,Gregory D. Schuler,P. J. De Jong,P. J. De Jong,Barbara J. Trask +62 more
TL;DR: This resource represents the first comprehensive integration of cytogenetic, radiation hybrid, linkage and sequence maps of the human genome and provides an independent validation of the sequence map and framework for contig order and orientation.
Journal ArticleDOI
Primase, the dnaG protein of Escherichia coli. An enzyme which starts DNA chains.
Lee Rowen,Arthur Kornberg +1 more
TL;DR: The sharp specificity of the dnaG protein in choice of template and the utilization of either deoxyribonucleotides or ribonucleoside triphosphates to produce a hybrid piece only a few residues long suggests that the dnG protein previously named RNA polymerase by renamed primase is being replaced by DNA polymerase III holoenzyme.
Journal ArticleDOI
Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes
Barbara J. Trask,Cynthia Friedman,Antonia Martin-Gallardo,Lee Rowen,Carolyn Akinbami,John W. Blankenship,Colin Collins,Dominique Giorgi,Shawn P. Iadonato,F Johnson,Wen Lin Kuo,Hillary Massa,Tammy Morrish,S. Naylor,Oanh T H Nguyen,Sylvie Rouquier,Todd M. Smith,David J. Wong,Janey Youngblom,Ger van den Engh +19 more
TL;DR: The finding that sequences flanking the OR-containing segment are duplicated on larger and different sets of chromosomes than the OR block itself demonstrates that the segment is part of a much larger, complex patchwork of subtelomeric duplications.