L
Lee Rowen
Researcher at Institute for Systems Biology
Publications - 65
Citations - 35324
Lee Rowen is an academic researcher from Institute for Systems Biology. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 39, co-authored 62 publications receiving 32743 citations. Previous affiliations of Lee Rowen include University of Washington & California Institute of Technology.
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Journal ArticleDOI
Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathway.
C. Chace Tydell,Elizabeth Sharon David-Fung,Jonathan E. Moore,Lee Rowen,Tom Taghon,Ellen V. Rothenberg +5 more
TL;DR: A major fraction of these early T lineage genes are a regulatory legacy from stem cells, including zinc finger transcription factor, helicase, and signaling adaptor genes, which was also shared by stem cells and multipotent progenitors, although down-regulated in other lineages.
Journal ArticleDOI
Transcription factor expression dynamics of early T-lymphocyte specification and commitment
Elizabeth Sharon David-Fung,Robert R. Butler,Gentian Buzi,Mary A. Yui,Rochelle A. Diamond,Michele K. Anderson,Lee Rowen,Ellen V. Rothenberg +7 more
TL;DR: T-cell identity has an essentially complex regulatory basis and a detailed framework for regulatory network modeling of T-cell specification is provided.
Journal ArticleDOI
Cloning, Characterization, and the Complete 56.8-Kilobase DNA Sequence of the Human NOTCH4 Gene
Linheng Li,Guyang M. Huang,Amy B. Banta,Amy B. Banta,Yu Deng,Yu Deng,Todd M. Smith,Penny Dong,Cynthia Friedman,Lei Chen,Barbara J. Trask,Thomas Spies,Lee Rowen,Leroy Hood,Leroy Hood +14 more
TL;DR: The first complete mammalian genomic sequence reported thus far in the Notch gene family, including a putative promoter region and 30 exons of the human NOTCH4 gene spanning 56.8 kb of DNA, were sequenced.
Journal ArticleDOI
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
Jeremy Manry,Paul Bastard,A Gervais,Tom Le Voyer,Jérémie Rosain,Quentin Philippot,Eleftherios Michailidis,Hans-Heinrich Hoffmann,Shohei Eto,Marina Garcia-Prat,Lucy Bizien,Alba Parra-Martínez,Rui-Fu Yang,Liis Haljasmägi,Mélanie Migaud,Karita Särekannu,Julia Maslovskaja,Nicolas de Prost,Yacine Tandjaoui-Lambiotte,Charles-Edouard Luyt,Blanca Amador-Borrero,Alexandre Gaudet,Julien Poissy,Pascal Morel,Pascale Richard,Fabrice Cognasse,Jesús Troya,Sophie Trouillet-Assant,Alexandre Belot,Kahina Saker,Pierre Garçon,Jacques G. Rivière,Jean-Christophe Lagier,Stéphanie Gentile,Lindsey B. Rosen,Elana Shaw,Tomohiro Morio,Junzo Tanaka,David Dalmau,Pierre-Louis Tharaux,Damien Sène,Alain Stepanian,Bruno Mégarbane,Vasiliki Triantafyllia,Arnaud Fekkar,James R. Heath,José Luis Franco,Juan-Manuel Anaya,Jordi Solé-Violán,Luisa Imberti,Andrea Biondi,Paolo Bonfanti,Riccardo Castagnoli,Ottavia M. Delmonte,Yu Zhang,Andrew L. Snow,Steven M. Holland,Catherine M. Biggs,Marcela Moncada-Vélez,Andrés Augusto Arias,Lazaro Lorenzo,Soraya Boucherit,Dany Anglicheau,Anna M. Planas,Filomeen Haerynck,Sotirija Duvlis,Tayfun Ozcelik,Sevgi Keles,Ahmed Aziz Bousfiha,Jalila El Bakkouri,Carolina Ramírez-Santana,Stéphane Paul,Qiang Pan-Hammarström,Lennart Hammarström,Annabelle Dupont,Alina Kurolap,Christine N. Metz,Alessandro Aiuti,Giorgio Casari,Vito Lampasona,Fabio Ciceri,Lucila Akune Barreiros,Elena Domínguez-Garrido,Mateus Vidigal,Mayana Zatz,Diederik van de Beek,Sabina Sahanic,Ivan Tancevski,Y. Stepanovskyy,Oksana Boyarchuk,Yoko Nukui,Miyuki Tsumura,Loreto Vidaur,Stuart G. Tangye,Sonia Burrel,Darragh Duffy,Lluis Quintana-Murci,Adam Klocperk,Nelli Y. Kann,Anna Shcherbina,Yu-Lung Lau,Daniel Leung,Matthieu Coulongeat,Julien Marlet,Rutger Koning,Luis F. Reyes,Angelique Chauvineau-Grenier,Fabienne Venet,Guillaume Monneret,Michel C. Nussenzweig,Romain Arrestier,Idris Boudhabhay,Hagit Baris-Feldman,David Hagin,Joost Wauters,Isabelle Meyts,Adam H Dyer,Sean Kennelly,Nollaig M. Bourke,Rabih Halwani,Fatemeh Saheb Sharif-Askari,Karim Dorgham,Jérôme Sallette,Souad Mehlal Sedkaoui,Suzan A AlKhater,Raül Rigo-Bonnin,Francisco Barreiro Morandeira,Lucie Roussel,Donald C. Vinh,Christian Erikstrup,Antonio Condino-Neto,Carolina Prando,Anastasiia Bondarenko,András N Spaan,Laurent Gilardin,Jacques Fellay,Stanislas Lyonnet,Kaya Bilguvar,Richard P. Lifton,Shrikant M. Mane,Mark Steven Anderson,Bertrand Boisson,Vivien Béziat,Shen-ying Zhang,Evangelos Andreakos,Olivier Hermine,Aurora Pujol,Pärt Peterson,Trine H. Mogensen,Lee Rowen,James J. Mond,Stéphanie Debette,Xavier de Lamballerie,Charles Burdet,Lila Bouadma,Marie Zins,Pere Soler-Palacín,Roger Colobran,Guy Gorochov,Xavier Solanich,Sophie Susen,Javier Martinez-Picado,Didier Raoult,Marc Vasse,Peter K. Gregersen,Lorenzo Piemonti,Carlos Rodríguez-Gallego,Luigi D. Notarangelo,Helen C. Su,Kai Kisand,Satoshi Okada,Anne Puel,Emmanuelle Jouanguy,Charles M. Rice,Pierre Tiberghien,Qian Zhang,Jean-Laurent Casanova,Laurent Abel,Aurélie Cobat +178 more
TL;DR: It is found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women.
Journal ArticleDOI
Analysis of the DNA sequence and duplication history of human chromosome 15
Michael C. Zody,Manuel Garber,Ted Sharpe,Sarah Young,Lee Rowen,Keith O'Neill,Charles A. Whittaker,Michael Kamal,Jean L. Chang,Christina A. Cuomo,Ken Dewar,Michael Fitzgerald,Chinnappa D. Kodira,Anup Madan,Shizhen Qin,Xiaoping Yang,Nissa Abbasi,Amr Abouelleil,Harindra Arachchi,Lida Baradarani,Brian Birditt,Scott Bloom,Toby Bloom,Mark L. Borowsky,Jeremy Burke,Jonathan Butler,April Cook,Kurt DeArellano,David DeCaprio,Lester Dorris,Monica Dors,Evan E. Eichler,Reinhard Engels,Jessica Fahey,Peter Fleetwood,Cynthia Friedman,Gary Gearin,Jennifer L. Hall,Grace Hensley,Ericka M. Johnson,Charlien Jones,Asha Kamat,Amardeep Kaur,Devin P. Locke,Anuradha Madan,Glen Munson,David B. Jaffe,Annie Lui,Pendexter Macdonald,Evan Mauceli,Jerome Naylor,Ryan Nesbitt,Robert Nicol,Sinéad B. O'Leary,Amber L Ratcliffe,Steven Rounsley,Xinwei She,Katherine M. B. Sneddon,Sandra Stewart,Carrie Sougnez,Sabrina M. Stone,Kerri Topham,Dascena Vincent,Shunguang Wang,Andrew Zimmer,Bruce W. Birren,Leroy Hood,Eric S. Lander,Chad Nusbaum +68 more
TL;DR: A detailed analysis of the duplication structure of human chromosome 15 finds that most of the intrachromosomal duplications seem to share a common ancestry, and demonstrates that some remaining gaps in the genome sequence are probably due to structural polymorphisms between haplotypes.