L
Leo Heijnen
Researcher at Leiden University
Publications - 43
Citations - 3549
Leo Heijnen is an academic researcher from Leiden University. The author has contributed to research in topics: Coronavirus & Genome. The author has an hindex of 21, co-authored 38 publications receiving 2458 citations. Previous affiliations of Leo Heijnen include Utrecht University.
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Journal ArticleDOI
Presence of SARS-Coronavirus-2 RNA in Sewage and Correlation with Reported COVID-19 Prevalence in the Early Stage of the Epidemic in the Netherlands
TL;DR: The detection of the virus RNA in sewage, even when the CO VID-19 prevalence is low, and the correlation between concentration in sewage and reported prevalence of COVID-19, indicate that sewage surveillance could be a sensitive tool to monitor the circulation of theirus in the population.
Journal ArticleDOI
Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana
Klaus F. X. Mayer,C. Schüller,R. Wambutt,George Murphy,Guido Volckaert,Thomas Pohl,A. Düsterhöft,Willem J. Stiekema,K.-D. Entian,Nancy Terryn,Barbara Harris,Wilhelm Ansorge,Petra Brandt,Leslie A. Grivell,Michael A. Rieger,M. Weichselgartner,V De Simone,B. Obermaier,R. Mache,Mario Müller,M. Kreis,Michel Delseny,Pere Puigdomènech,Martin D. Watson,T. Schmidtheini,B. Reichert,D. Portatelle,Manuel Pérez-Alonso,Marc Boutry,Ian Bancroft,P. Vos,Joerg Hoheisel,Wolfgang Zimmermann,H. Wedler,P. Ridley,S. A. Langham,B. McCullagh,L. Bilham,Johan Robben,J. Van der Schueren,B. Grymonprez,Y. J. Chuang,F. Vandenbussche,M. Braeken,I. Weltjens,Marleen Voet,I. Bastiaens,Rita Aert,E. Defoor,T. Weitzenegger,G. Bothe,U. Ramsperger,H. Hilbert,M. Braun,E. Holzer,A. Brandt,Sander Peters,M. van Staveren,Wim G. Dirkse,P. Mooijman,R. Klein Lankhorst,M. Rose,J. Hauf,P. Kötter,S. Berneiser,S. Hempel,M. Feldpausch,S. Lamberth,H. Van den Daele,A. De Keyser,C. Buysshaert,J. Gielen,R. Villarroel,R. De Clercq,M. Van Montagu,Jane Rogers,A. Cronin,Michael A. Quail,S. Bray-Allen,L. Clark,J. Doggett,S. Hall,M. Kay,Nicola Lennard,K. McLay,R. Mayes,A. Pettett,Marie-Adèle Rajandream,M. Lyne,Vladimir Benes,S. Rechmann,D. Borkova,H. Blöcker,M. Scharfe,M. Grimm,T. H. Löhnert,S. Dose,M. de Haan,A.C. Maarse,M. Schäfer,S Müller-Auer,C. Gabel,M. Fuchs,Berthold Fartmann,K. Granderath,D. Dauner,A. Herzl,Sindy Neumann,Anagnostis Argiriou,D. Vitale,Rosario Liguori,E. Piravandi,O. Massenet,F. Quigley,G. Clabauld,A. Mündlein,R. Felber,S. Schnabl,R. Hiller,W. Schmidt,A. Lecharny,S. Aubourg,F. Chefdor,R. Cooke,C. Berger,A. Montfort,Elena Casacuberta,T. Gibbons,N. Weber,Micheline Vandenbol,M. D. Bargues,Javier Terol,A. Torres,A Perez-Perez,Bénédicte Purnelle,E. Bent,S. Johnson,D. Tacon,T. Jesse,Leo Heijnen,S. Schwarz,Patrik Scholler,Steffen Heber,P. Francs,C. Bielke,Dmitrij Frishman,D. Haase,Kai Lemcke,Hans-Werner Mewes,S. Stocker,P. Zaccaria,Michael W. Bevan,Richard K. Wilson,M. de la Bastide,K. Habermann,L. Parnell,Neilay Dedhia,L. Gnoj,K. Schutz,E. Huang,Lori Spiegel,M. Sehkon,Joseph A. Murray,P. Sheet,Matt Cordes,J. Abu-Threideh,T. Stoneking,Joelle Kalicki,Tina Graves,G. Harmon,Jennifer Edwards,P. Latreille,Laura Courtney,J. Cloud,A. Abbott,Kelsi Scott,David W. Johnson,Patrick Minx,David Bentley,Bob Fulton,N. Miller,T. Greco,K. Kemp,Jason B. Kramer,Lucinda Fulton,Elaine R. Mardis,Mike Dante,Kymberlie H. Pepin,LaDeana W. Hillier,Joanne O. Nelson,John Spieth,E. Ryan,S. Andrews,C. Geisel,Dan Layman,Hui Du,Johar Ali,A. Berghoff,K. Jones,K. Drone,M. Cotton,Corinne E. Joshu,B. Antonoiu,M. Zidanic,Cindy Strong,H. Sun,B. Lamar,C. Yordan,P. Ma,P. Ma,J. Zhong,J. Zhong,R. Preston,D. Vil,M. Shekher,A. Matero,R. Shah,I'k. Swaby,A. O'Shaughnessy,M. Rodriguez,J. Hoffman,S. Till,S. Granat,Nadim Shohdy,A. Hasegawa,Abdul Hameed,M. Lodhi,A. Johnson,A. Johnson,Ellson Y. Chen,Ellson Y. Chen,Marco A. Marra,Robert A. Martienssen,W. R. McCombie +233 more
TL;DR: Analysis of 17.38 megabases of unique sequence, representing about 17% of the Arabidopsis genome, reveals 3,744 protein coding genes, 81 transfer RNAs and numerous repeat elements.
Posted ContentDOI
Presence of SARS-Coronavirus-2 in sewage
TL;DR: The detection of the virus in sewage, even when the COVID-19 incidence is low, indicates that sewage surveillance could be a sensitive tool to monitor the circulation of theirus in the population.
Journal ArticleDOI
Implementation of environmental surveillance for SARS-CoV-2 virus to support public health decisions: opportunities and challenges.
TL;DR: In this paper, the authors reviewed the strength of evidence, opportunities and challenges for the application of sewage surveillance to inform public health decision-making, including sampling sites, strategies, sample transport, storage and quantification methods, together with the approach and evidence base for quantifying prevalence of infection from measured wastewater concentration.
Journal ArticleDOI
Direct comparison of selected methods for genetic categorisation of Cryptosporidium parvum and Cryptosporidium hominis species.
Rachel M. Chalmers,Christobel Ferguson,Simone M. Cacciò,Robin B. Gasser,Youssef G. Abs EL-Osta,Leo Heijnen,Lihua Xiao,Kristin Elwin,Stephen J. Hadfield,Martha Irvine Sinclair,Melita A. Stevens +10 more
TL;DR: This trial provided, for the first time, a direct comparison of multiple methods for the genetic characterisation of C. parvum and C. hominis samples and found SSCP analysis of ITS-2 to have superior utility and determined 'subgenotypes' in samples containing DNA from both species.