L
Leslie M. Loew
Researcher at University of Connecticut
Publications - 288
Citations - 19918
Leslie M. Loew is an academic researcher from University of Connecticut. The author has contributed to research in topics: Membrane & Membrane potential. The author has an hindex of 68, co-authored 276 publications receiving 18813 citations. Previous affiliations of Leslie M. Loew include Cornell University & University of Connecticut Health Center.
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Journal ArticleDOI
The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models.
Michael Hucka,Andrew Finney,Herbert M. Sauro,Hamid Bolouri,Hamid Bolouri,John Doyle,Hiroaki Kitano,Adam P. Arkin,Benjamin Bornstein,Dennis Bray,Athel Cornish-Bowden,Autumn A. Cuellar,S. Dronov,E. D. Gilles,Martin Ginkel,V. Gor,Igor Goryanin,W. J. Hedley,T. C. Hodgman,J.-H.S. Hofmeyr,Peter Hunter,Nick Juty,J. L. Kasberger,Andreas Kremling,Ursula Kummer,N Le Novère,Leslie M. Loew,D. Lucio,Pedro Mendes,E. Minch,Eric Mjolsness,Yoichi Nakayama,Melanie R. Nelson,Poul M. F. Nielsen,T. Sakurada,James C. Schaff,Bruce E. Shapiro,Thomas S. Shimizu,H. D. Spence,Jörg Stelling,Koichi Takahashi,Masaru Tomita,John Wagner,J. Wang +43 more
TL;DR: This work summarizes the Systems Biology Markup Language (SBML) Level 1, a free, open, XML-based format for representing biochemical reaction networks, a software-independent language for describing models common to research in many areas of computational biology.
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Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms.
TL;DR: Recent studies of the three-dimensional in vivo structures of well-ordered protein assemblies, such as collagen, microtubules and muscle myosin, are beginning to establish SHIM as a nondestructive imaging modality that holds promise for both basic research and clinical pathology.
Journal ArticleDOI
Membrane potential can be determined in individual cells from the nernstian distribution of cationic dyes.
TL;DR: The rhodamine esters are nontoxic, highly fluorescent dyes which do not form aggregates or display binding-dependent changes in fluorescence efficiency and allows membrane potentials in individual cells to be continuously monitored, quantitatively related to the contrast between intracellular and extracellular fluorescence.
Journal ArticleDOI
High-resolution nonlinear optical imaging of live cells by second harmonic generation.
TL;DR: In this paper, the authors adapted a laser scanning microscope with a titanium sapphire femtosecond pulsed laser and transmission optics to produce live cell images based on the nonlinear optical phenomenon of second harmonic generation (SHG).
Journal Article
High-resolution nonlinear optical imaging of live cells by second harmonic generation
TL;DR: It was found that chirality plays a significant role in the mechanism of contrast generation, and it is also shown that SHIM is highly sensitive to membrane potential, with a depolarization of 25 mV resulting in an approximately twofold loss of signal intensity.