M
M. Margarita Behrens
Researcher at Salk Institute for Biological Studies
Publications - 97
Citations - 9693
M. Margarita Behrens is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Parvalbumin & Chromatin. The author has an hindex of 39, co-authored 89 publications receiving 7718 citations. Previous affiliations of M. Margarita Behrens include University of California, San Diego & Mario Negri Institute for Pharmacological Research.
Papers
More filters
Journal ArticleDOI
Global Epigenomic Reconfiguration During Mammalian Brain Development
Ryan Lister,Ryan Lister,Eran A. Mukamel,Joseph R. Nery,Mark A. Urich,Clare A. Puddifoot,Nicholas D. Johnson,Jacinta Lucero,Yun Huang,Andrew J. Dwork,Matthew D. Schultz,Matthew D. Schultz,Miao Yu,Julian Tonti-Filippini,Holger Heyn,Shijun Hu,Joseph C. Wu,Anjana Rao,Manel Esteller,Chuan He,Fatemeh Haghighi,Terrence J. Sejnowski,Terrence J. Sejnowski,M. Margarita Behrens,Joseph R. Ecker +24 more
TL;DR: The results extend the knowledge of the unique role of DNA methylation in brain development and function, and offer a new framework for testing the role of the epigenome in healthy function and in pathological disruptions of neural circuits.
Journal ArticleDOI
Interleukin-1β Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of Kinases
Barbara Viviani,Stefano Bartesaghi,Fabrizio Gardoni,Annamaria Vezzani,M. Margarita Behrens,Tamas Bartfai,M. Binaglia,Emanuela Corsini,M. Di Luca,C. L. Galli,Marina Marinovich +10 more
TL;DR: The data suggest that IL-1β increases NMDA receptor function through activation of tyrosine kinases and subsequent NR2A/B subunit phosphorylation, which may contribute to glutamate-mediated neurodegeneration.
Journal ArticleDOI
Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase
M. Margarita Behrens,Sameh S. Ali,Diep N. Dao,Jacinta Lucero,Grigoriy Shekhtman,Kevin L. Quick,Laura L. Dugan +6 more
TL;DR: It is shown that exposure of mice to ketamine induced a persistent increase in brain superoxide due to activation in neurons of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, which suggests that NADPH oxidase may represent a novel target for the treatment of ketamine-induced psychosis.
Journal ArticleDOI
A loss of parvalbumin-containing interneurons is associated with diminished oscillatory activity in an animal model of schizophrenia
TL;DR: It is proposed that a decrease in intrinsic GABAergic signaling may be responsible, at least in part, for the prefrontal and hippocampal hypofunctionality observed during task performance, which is consistently observed in animal models as well as in schizophrenia in humans.
Journal ArticleDOI
Single-cell methylomes identify neuronal subtypes and regulatory elements in mammalian cortex
Chongyuan Luo,Christopher L. Keown,Laurie Kurihara,Jingtian Zhou,Jingtian Zhou,Yupeng He,Yupeng He,Jun-Hao Li,Rosa Castanon,Jacinta Lucero,Joseph R. Nery,Justin P. Sandoval,Brian Bui,Terrence J. Sejnowski,Terrence J. Sejnowski,Timothy T. Harkins,Eran A. Mukamel,M. Margarita Behrens,Joseph R. Ecker +18 more
TL;DR: A comprehensive map of methylation variation in neuronal cell populations, including a between-species comparison, illustrates how epigenetic diversity plays important roles in neuronal development.